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Methods and compositions for inhibiting 5a 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/20
출원번호 US-0904443 (1992-07-01)
발명자 / 주소
  • Liao Shutsung (Chicago IL) Liang Tehming (Centerville OH)
출원인 / 주소
  • Arch Development Corp. (Chicago IL 02)
인용정보 피인용 횟수 : 29  인용 특허 : 0

초록

Disclosed are a novel class of anti-androgenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, according to the following formula: CH3-(CH2)a-(CR1R2CH〓CH)b-(CH2)c-COOH, wherein R1 and R2 are each either hydrogen or a halogen; wherein a and c are i

대표청구항

A method of selectively inhibiting 5a-reductase in an intact cell, comprising contacting said cell with a C14-C22 unsaturated aliphatic fatty acid or alcohol in an amount sufficient to prevent reduction of androgen by the 5a-reductase.

이 특허를 인용한 특허 (29)

  1. DeLong, Mitchell Anthony, 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use.
  2. deLong,Mitchell Anthony, 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use.
  3. Bryhn, Morten; Holmeide, Anne Kristin; Rosman, Jenny, Alpha-substituted omega-3 lipids that are activators or modulators of the peroxisome proliferators-activated receptor (PPAR).
  4. deLong, Mitchell A.; Sturdivant, Jill Marie, Amino acid salts of prostaglandins.
  5. deLong, Mitchell A.; Sturdivant, Jill Marie, Amino acid salts of prostaglandins.
  6. deLong, Mitchell A.; Sturdivant, Jill Marie, Amino acid salts of prostaglandins.
  7. deLong, Mitchell Anthony; Soper, David Lindsey; Wos, John August; De, Biswanath, C16 unsaturated FP-selective prostaglandins analogs.
  8. Galano Hector Luis,ARX, Composition for use in sculpturing, a sculpturing piece comprising the composition and method for obtaining the piece.
  9. deLong, Mitchell Anthony; McIver, John McMillan; Youngquist, Robert Scott, Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins.
  10. deLong,Mitchell Anthony; McIver,John McMillan; Youngquist,Robert Scott, Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins.
  11. DeLong, Mitchell Anthony; McIver, John McMillan; Youngquist, Robert Scott, Compositions and methods for treating hair loss using non-naturally occurring prostaglandins.
  12. DeLong,Mitchell Anthony; McIver,John McMillan; Youngquist,Robert Scott, Compositions and methods for treating hair loss using non-naturally occurring prostaglandins.
  13. deLong, Mitchell A.; McIver, John M.; Youngquist, Robert S., Compositions and methods for treating hair loss using non-naturally occurring prostaglandins.
  14. deLong, Mitchell A.; McIver, John M.; Youngquist, Robert S., Compositions and methods for treating hair loss using non-naturally occurring prostaglandins.
  15. Chilton, Floyd; Lu, Fan, Compositions, methods, and kits for polyunsaturated fatty acids from microalgae.
  16. Bryhn, Morten; Kopecky, Jan; Holmeide, Anne Kristin, Compounds.
  17. deLong, Mitchell A.; McIver, John M.; Youngquist, Robert S., Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives.
  18. deLong, Mitchell A.; McIver, John M.; Youngquist, Robert S., Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives.
  19. Simoulidis,Sofia; Rosevear,Jeffrey William; Dobkowski,Brian John, Cosmetic emulsions with inorganic sunscreens stabilized with conjugated linoleic acid.
  20. Rosevear,Jeffrey William; Siciliano,Marcina; Dobkowski,Brian John; Dasgupta,Bivash Ranjan; Huang,Lei, Cosmetic emulsions with sunscreens and conjugated linoleic acid.
  21. Alaluf Simon,GBX ; Barrett Karen Elizabeth,GBX ; Green Martin Richard,GBX ; Ottey Karen Angela,NLX ; Rawlings Anthony Vincent,GBX, Cosmetic method of treating skin.
  22. Citernesi, Ugo Raffaello, Cosmetic or pharmaceutical composition for topical use to prevent or differ androgenetic alopecia.
  23. Liao, Shutsung; Hiipakka, Richard, Method and compositions for regulation of 5-alpha reductase activity.
  24. DeLong,Mitchell Anthony, Method of treating a condition by administering a prostaglandin derivative.
  25. Liao, Shutsung; Hiipakka, Richard A., Methods and compositions for regulation of 5-α-reductase activity.
  26. Hart,Kelly Denise; Siciliano,Marcina; Rosevear,Jeffrey William; Dobkowski,Brian John, Oil continuous phase cosmetic emulsions with conjugated linoleic acid.
  27. See Jackie R., PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction.
  28. Weinkauf Ronni ; Santhanam Uma ; Palanker Laura Rose ; Januario Thomas Eugene ; Brinker Anita, Petroselinic acid as an anti-irritant in compositions containing alpha-hydroxy acids.
  29. Hwang,Cheng Shine; Henry,James P.; Ahluwalia,Gurpreet S.; Shander,Douglas, Reduction of hair growth.

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