Subcutaneous implantable multiple agent delivery system
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
A61K-009/22
출원번호
US-0151377
(1993-11-12)
발명자
/ 주소
Giampapa Vincent C. (89 Valley Rd. Montclair NJ 07042)
인용정보
피인용 횟수 :
91인용 특허 :
0
초록▼
An implantable multiple-agent biologic delivery system includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface and having at least one internal chamber which is in fluid communication with the porous surface. The system includes a
An implantable multiple-agent biologic delivery system includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface and having at least one internal chamber which is in fluid communication with the porous surface. The system includes a dome proportioned for selectable detachable securement to the chamber of the pod. The dome includes interior chambers, each in fluid communication with the interior of the pod. Bio-acting agents, such as hormones, enzymes, biologic response modifiers, free radical scavengers, and other genetically altered cell cultures may be provided, within the chambers of the dome, prior to implantation. Such agents within the dome will, through the use of time release micropumps, enter the interior chambers of the pod for transmission, through the porous surfaces into a growth factor stimulated capillary matrix and then to the bloodstream of the user. The pod may be removed, refilled, and resecured to the dome upon exhaustion of its contents or upon medical requirement for changes in medication, or may be percutaneously refilled in situ through injection into the dome. The surface of the pod may be treated with one or more vascular growth factors or related biologic molecules.
대표청구항▼
A removable subcutaneously implantable, multiple-agent delivery system, comprising: (a) a pod for subcutaneous implantation beneath the dermis of the human body, said pod comprising a porous surface between an interior and exterior of a bottom thereof and further comprising fluid transfer means in f
A removable subcutaneously implantable, multiple-agent delivery system, comprising: (a) a pod for subcutaneous implantation beneath the dermis of the human body, said pod comprising a porous surface between an interior and exterior of a bottom thereof and further comprising fluid transfer means in fluid communication with said porous surface, said pod having an opening at a top thereof, said pod formed of a biocompatible material, the exterior of the bottom of said pod provided with one or more vascular growth factors to promote growth of blood capillaries into and about said porous surface; (b) a dome proportioned for detachable securement about said opening of said pod, said dome including at least one chamber having selectable fluid communication with said fluid transfer means of said pod, in which bio-acting materials may be stored within said chambers of said dome prior to implantation, said dome formed of a biocompatible material; and (c) programmable time dependent biological agent release means within said chambers of said dome and said fluid transfer means of said pod, whereby said agents are controllably released from said chamber of said dome and into said pod and, therefrom, through said porous surface into the bloodstream, in which said dome, after exhaustion of the agents there within, may be removed, refilled and resecured to said pod.
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