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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0927254 (1992-08-07) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 359 인용 특허 : 0 |
A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for pr
A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.
A liquid-handling instrument for transferring liquid from one container to another comprising: a stationary worksurface having machined registration elements for accurately locating and supporting a modular container station for holding said containers of liquid; a pipette subsystem for aspirating a
A liquid-handling instrument for transferring liquid from one container to another comprising: a stationary worksurface having machined registration elements for accurately locating and supporting a modular container station for holding said containers of liquid; a pipette subsystem for aspirating and dispensing liquid, said pipette subsystem comprising a pipette tip coupled to a capacitance sensor; a robotic translation subsystem for moving said pipette tip to all containers on said worksurface and into and out of said containers; a gauge block securely fastened to and accurately positioned on said worksurface relative to said registration elements, and having surfaces substantially orthogonal to directions of movement of said pipette tip by said robotic translation subsystem; and a control subsystem for automatically managing said liquid transfers; wherein said control subsystem controls said robotic translation subsystem to move said pipette tip to each of said surfaces on said gauge block wherein the pipette tip and the capacitance sensor sense the position of the machined surface of said gauge block thereby establishing a home position on said worksurface for said liquid transfers.
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