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Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for m 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-003/00
  • C12N-009/96
  • C08G-065/32
출원번호 US-0151481 (1993-11-12)
발명자 / 주소
  • Harris J. Milton (Huntsville AL)
출원인 / 주소
  • Shearwater Polymers, Inc. (Huntsville AL 02)
인용정보 피인용 횟수 : 253  인용 특허 : 0

초록 ▼

A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble, hydrolytically stable for extended periods, and forms hydrolytically stable linkages with thiol moieties.

대표청구항

An activated poly(ethylene glycol) derivative having the structure: R－CH2CH2－(OCH2CH2)n－Y wherein n equals 5 to 3,000, Y is －SO2－CH〓CH2, and R is selected from the group consisting of HO－, H3CO－, X－CH2－CH2－SO2－, where X is halogen, and CH2〓CH－SO2－.

이 특허를 인용한 특허 (253)

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