[특허]Device for processing biological specimens for analysis of nucleic acids

Device for processing biological specimens for analysis of nucleic acids 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12Q-001/70
출원번호	US-0836348 (1992-03-03)
국제출원번호	PCT/US90/06768 (1990-11-16)
§371/§102 date	19920303 (19920303)
국제공개번호	WO-9107486
발명자 / 주소	Stapleton Marilyn J. (Durham NC)
출원인 / 주소	Gene Tec Corporation (Durham NC 02)
인용정보	피인용 횟수 : 167 인용 특허 : 0

초록 ▼

A system is provided for the automated detection of target nucleic acid sequences in which multiple biological samples are individually incorporated into matrices within carriers in a two-dimensional format. The matrix carrier is an inexpensive, disposable unit that represents a closed system separating the specimens. The system integrates sample preparation within the matrix and facilitates biochemical reactions, addition of reagents and washes, removal of waste fluids, temperature control and the automated processing thereof. The carriers are processed in stepwise treatments that expose, amplify, and detect the presence or absence of specific genetic entities in each sample. The nucleic acids or other desired biological components held within the matrices are treated by one or more of the techniques such as amplification, electrophoresis, analyte-receptor binding or hybridization as selected for the desired analysis. Different types of carriers are used for different kinds of diagnostic tests or test panels. Different primer and polymerase molecules may be used to replicate the target sequences of nucleic acids in the sample. The system also includes a heating and a passive cooling system that will provide rapid thermal cycling in a two-dimensional format for denaturation and amplification protocols so requiring them, or maintain constant temperatures for isothermal amplification and hybridization protocols. The system is adaptable to a variety of non-isotopic labels. The two-dimensional format lends itself to digitizing signals in a two-dimensional array for image analysis. Microscopic interpretation is possible with or without image analysis.

대표청구항 ▼

An apparatus for automated liquid delivery to and precise temperature control of samples immobilized on a surface of a carrier device for the detection of genetic material comprising: (a) a reaction chamber for situating the samples, said samples individually immobilized in a thin, flat carrier device in said apparatus during treatments; said carrier device comprising a top piece and a bottom piece, said bottom piece having a specimen holding area, said top piece having a closed position; said top piece and said bottom piece hinged together along a first side of said bottom piece, said top piece having a first area that extends beyond said first side, wherein the top piece may be caused to hingedly move away from the bottom piece and upward from the closed position to an open position; and said bottom piece having an overlap area on a second side of said bottom piece, said overlap area extending beyond said top piece, said overlap area having a fluid receiving area; said reaction chamber containing a tray rack for holding a plurality of carrier devices; (b) reservoirs for treatment liquids; (c) treatment liquid transfer lines, said reservoirs connected to the reaction chamber by means of said treatment liquid transfer lines; (d) means to control the timing and volume of treatment liquids delivered to samples through liquid transfer lines; said carriers situated in said tray rack in a generally horizontal position so that liquids are dispensed sequentially into an end of each carrier and flow over said immobilized sample and the liquids exit the carrier at the end of the carrier opposite the end of the carrier where liquids are dispensed; (e) a pump to cause the treatment liquids to move through the treatment liquid transfer lines to the samples in the reaction chamber, (f) means to regulate and rapidly change temperature of the samples in said flat carrier devices in the reaction chamber; and (g) means to contain used treatment liquids away from the samples; wherein liquid delivery and precise temperature control are controlled by a programmable central microprocessor.

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Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby.
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Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby.
상세보기
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby.
상세보기
Burgoyne Leigh Alexander,AUX, Solid medium and method for DNA storage.
상세보기
Burgoyne Leigh Alexander,AUX, Solid medium and methods for processing a sample of genetic material.
상세보기
Ackley Donald E. ; Sheldon Edward L. ; Krihak Michael K., Stacked, reconfigurable system for electrophoretic transport of charged materials.
상세보기
Goldberg, Martin J; Diggelman, Martin; Hubbell, Earl A.; McGall, Glenn H.; Ngo, Nam Quoc; Morris, MacDonald; Yamamoto, Melvin; Tan, Jennifer; Rava, Richard P., Substrate preparation process.
상세보기
Gao, Chuan; Yu, Tianyue, System and method for bubble removal.
상세보기
Gao, Chuan; Yamamoto, Melvin, System and method for making lab card by embossing.
상세보기
Shirazi, Mohsen, System and method for processing large number of biological microarrays.
상세보기
Stern David, System and methods for detection of labeled materials.
상세보기
Goldberg, Martin J.; Diggelman, Martin; Hubbell, Earl A.; McGall, Glenn H.; Nam, Ngo; Morris, MacDonald S.; Yamamoto, Melvin; Tan, Jennifer; Rava, Richard, System for photolithographic synthesis of polymer arrays.
상세보기
Ackley Donald E. ; Sheldon Edward L. ; Krihak Michael K., System including functionally separated regions in electrophoretic system.
상세보기
Kaiser, Michael D.; Smith, David R., System, method, and product for imaging probe arrays with small feature size.
상세보기
Kaiser, Michael D.; Smith, David R., System, method, and product for imaging probe arrays with small feature sizes.
상세보기
Kaiser, Michael D.; Smith, David R., System, method, and product for imaging probe arrays with small feature sizes.
상세보기
Stern David, Systems and methods for detection of labeled materials.
상세보기
Stern, David, Systems and methods for detection of labeled materials.
상세보기
Ecker, David J.; Hofstadler, Steven A.; Hall, Thomas A.; Sannes-Lowery, Kristin, Systems and methods for rapid identification of nucleic acid variants.
상세보기
Hofstadler, Steven A.; Gutierrez, Jose R.; Hannis, James C.; Drader, Jared J.; Bare, Rex O.; Smith, Jeffrey C.; Gleason, Paul J.; Nathanson, Jared; Bergold, Ronald K.; Miller, Robert D.; Oberkramer, Kevin S., Systems for bioagent indentification.
상세보기
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Systems for rapid identification of pathogens in humans and animals.
상세보기
Ecker, David J.; Eshoo, Mark W., Targeted whole genome amplification method for identification of pathogens.
상세보기
Harley Calvin Bruce ; Kim Nam Woo ; Weinrich Scott Lawrence, Telomerase activity assays.
상세보기
Harley Calvin Bruce ; Kim Nam Woo ; Weinrich Scott Lawrence, Telomerase activity assays.
상세보기
Harley Calvin Bruce ; Kim Nam Woo ; Weinrich Scott Lawrence, Telomerase activity assays.
상세보기
Harley Calvin Bruce ; Kim Nam Woo ; Weinrich Scott Lawrence, Telomerase activity assays.
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Pottathil,Raveendran; Streifel,Jerome Anton, Thermal strip thermocycler.
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Poulsen, Tim Svenstrup; Matthiesen, Steen Hauge, Tissue processing apparatus.
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Poulsen, Tim Svenstrup; Matthiesen, Steen Hauge, Tissue processing apparatus.
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Poulsen, Tim Svenstrup; Matthiesen, Steen Hauge, Tissue processing apparatus.
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Yuen, Po Ki, Well frame including connectors for biological fluids.
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Gunter, Ian Alan, Zone heating of specimen carriers.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Device for processing biological specimens for analysis of nucleic acids 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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연합인증

Device for processing biological specimens for analysis of nucleic acids 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허를 인용한 특허 (167)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트