[특허]Pharmaceutical sustained release matrix

Pharmaceutical sustained release matrix 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/22 A61K-009/24 A61K-009/26
출원번호	US-0373914 (1995-01-17)
발명자 / 주소	Radebaugh Galen W. (Maple Glen PA) Julian Thomas N. (Horsham PA) Glinecke Robert (Glenside PA)
출원인 / 주소	McNeil-PPC, Inc. (Milltown NJ 02)
인용정보	피인용 횟수 : 81 인용 특허 : 0

초록 ▼

A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.

대표청구항 ▼

A process of preparing a pharmaceutical active sustained release shaped and compressed homogeneous tablet or tablet layer characterized by a long-lasting slow and relatively regular incremental release of the pharmaceutical active upon administration comprising the following steps: A) forming a granulating agent by dissolving 5-30 parts, by weight of total non-active components of the tablet, of povidone in alcohol or an alcohol-water mixture; B) blending together the following ingredients in dry powder form: an effective amount of pharmaceutical active which is sufficient to comprise about 66 to 96 percent by weight of the total tablet composition; and the following range of amounts of non-active ingredients given in a range of parts by weight of the total non-active components of the tablet; ________________________________ - Ingredient Parts by Weight ________________________________ ethylcellulose 3-12 wicking agent 10-35 erosion promoter 5-25 ________________________________ C) adding the granulating agent from Step A to the blended powders from Step B, and forming a wet granulation; D) drying the wet granulation of Step C; E) milling the dried granulation from Step D; F) thoroughly blending the milled dried granulation from Step E with the following ingredients in dry powder form: ________________________________ - Ingredient Parts by Weight ________________________________ erosion Promoter 1-20 wicking agent 3-20 lubricant 0-10 glidant 0-10; and ________________________________ G) compressing the final granulation from Step F into a tablet or tablet layer wherein the active to non-active component ratio is at least about 2:1.

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Kanikanti, Venkata-Rangarao; Rupp, Roland; Weber, Wolfgang; Deuringer, Peter; Henck, Jan-Olav; Staβ, Heino; Nishioka, Takaaki; Katakawa, Yoshifumi; Taniguchi, Chika; Ichihashi, Hitoshi, Sustained-release preparations of quinolone antibiotics and method for preparation thereof.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
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연합인증

Pharmaceutical sustained release matrix 원문보기

초록 ▼

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Pharmaceutical sustained release matrix 원문보기

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연구과제 타임라인

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이 특허를 인용한 특허 (81)

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