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Oligonucleotide-linked magnetic particles and uses thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-019/34
  • C12Q-001/68
  • G01N-033/553
출원번호 US-0272372 (1994-07-06)
우선권정보 GB-0027157 (1988-11-21); GB-0027158 (1988-11-21); GB-0027159 (1988-11-21); GB-0027160 (1988-11-21); GB-0027166 (1988-11-21); GB-0027167 (1988-11-21); GB-0006643 (1989-03-22)
발명자 / 주소
  • Hornes Erik (Oslo NOX) Korsnes Lars (Oslo NOX)
출원인 / 주소
  • Dynal AS (Oslo NOX 03)
인용정보 피인용 횟수 : 312  인용 특허 : 0

초록

Monodisperse, superparamagnetic particles carrying a plurality of molecules of an oligonucleotide are disclosed and may be used inter alia for sequencing single-stranded nucleic acids. The oligonucleotide may be covalently attached or affinity bonded to the particles either by their 3′or 5′termini.

대표청구항

A plurality of monodisperse, superparamagnetic particles, wherein: each particle comprises (i) superparamagnetic iron oxide dispersed within a polymer particle, (ii) a coating which reduces non specific binding, and (iii) a functional group carried by said coating for bonding a nucleic acid the part

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