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Conjugate, its preparation and use and a substrate prepared with the conjugate 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/725
  • A61L-033/00
출원번호 US-0211224 (1994-03-25)
우선권정보 SE-0002798 (1991-09-26)
국제출원번호 PCT/SE92/00672 (1992-09-25)
§371/§102 date 1994May2 (1994May2)
국제공개번호 WO-9305793 (1993-04-01)
발명자 / 주소
  • Larsson Rolf (Uppsala SEX) Westberg David (Uppsala SEX) Formgren Birgitta (Uppsala SEX) Uhlin Anders (Uppsala SEX)
출원인 / 주소
  • Corline Systems AB (Uppsala SEX 03)
인용정보 피인용 횟수 : 45  인용 특허 : 0

초록

The present invention relates to a water-soluble conjugate having antithrombin-binding activity comprising a substantially straight-chained organic polymer backbone having at least 30 molecules of sulfated glycosaminoglycans distributed along the polymer backbone, wherein the sulfated glycosaminogly

대표청구항

A water-soluble conjugate having antithrombin-binding activity comprising a biologically inert carrier in the form of a substantially straight-chained organic polymer selected from the group consisting of polylysine, polyornithine, a polysaccharide and an aliphatic polymer, having chemically reactiv

이 특허를 인용한 특허 (45)

  1. Kadowaki, Koji; Fujita, Masaki; Sakaguchi, Yuka; Tanahashi, Kazuhiro, Antithrombotic material.
  2. Larsson, Rolf, Aqueous solution comprising a macromolecular conjugate of heparin for the treatment of blood vessels.
  3. Green, Howard; Compton, Bruce; Corey, George; Djian, Philippe, Conjugates of agents and transglutaminase substrate linking molecules.
  4. Kellogg, Brenda A.; Singh, Rajeeva; Chari, Ravi V. J., Conjugation methods.
  5. Kellogg, Brenda A.; Singh, Rajeeva; Chari, Ravi V. J., Conjugation methods.
  6. Hsu, Li-Chien, Drug eluting coatings for medical implants and methods of use.
  7. Berry, Leslie; Andrew, Maureen, Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates.
  8. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama-Elbert, Shelly E., Growth factor modified protein matrices for tissue engineering.
  9. Cleek, Robert L.; Drumheller, Paul D; Li, Mei; Mardirosian, Nora, Heparin entities and methods of use.
  10. Lassila, Riitta; Kovanen, Petri; Lindstedt, Ken, Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions.
  11. Lassila,Riitta; Kovanen,Petri; Lindstedt,Ken, Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions.
  12. Lassila,Riitta; Kovanen,Petri; Lindstedt,Ken, Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions.
  13. Leontein, Karin; Antoni, Per; Nyström, Daniel; Begovac, Paul; Pietrzak, Krzysztof, Immobilised biological entities.
  14. Leontein, Karin; Antoni, Per; Nyström, Daniel; Begovac, Paul; Pietrzak, Krzysztof, Immobilised biological entities.
  15. Leontein, Karin; Antoni, Per; Nyström, Daniel; Begovac, Paul; Pietrzak, Krzysztof, Immobilised biological entities.
  16. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities containing heparin having high biological activity following mechanical manipulation.
  17. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having a high degree of biological activity.
  18. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having a high degree of biological activity.
  19. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having a high degree of biological activity.
  20. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having a high degree of biological activity.
  21. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having a high degree of biological activity following sterilization.
  22. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having high biological activity following mechanical manipulation.
  23. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Immobilized biologically active entities having high biological activity following mechanical manipulation.
  24. Nakada Kazuhiko,JPX ; Matano Yutaka,JPX, Liquid for contact lenses.
  25. Schense, Jason; Watson, John; Arrighi, Isabelle, Local treatment of bone defects.
  26. Cleek, Robert L.; Daly, Michael D.; Pietrzak, Krzysztof R., Medical device capable of being compacted and expanded having anti-thrombin III binding activity.
  27. Leslie Berry CA; Maureen Andrew CA, Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates.
  28. Barron Hal V. ; Botvinick Elias, Method for promoting angiogenesis using heparin and adenosine.
  29. Hal V. Barron ; Elias Botvinick, Method for treating occlusive peripheral vascular disease and coronary disease.
  30. Larm, Olle; Gouda, Ibrahim, Method of covalent coupling.
  31. Chen, Xiaoxi Kevin; Li, Xinfang, Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane.
  32. Kellogg, Brenda A.; Singh, Rajeeva; Chari, Ravi V. J., Methods for preparing antibody-drug conjugates.
  33. Berry,Leslie Roy; O'Brodovich, legal representative,Hugh; Chan,Anthony Kam Chuen; Andrew, deceased,Maureen, Methods of coating a device using anti-thrombin heparin.
  34. Sanchez, Javier; Larsson, Rolf, Molecular assembly on a substrate.
  35. Ajay Kumar Luthra GB; Shivpal Singh Sandhu GB, Non-thrombogenic and anti-thrombogenic polymers.
  36. Charier, Gaëlle; Müller-Maissen, Manuela; Jen, Anna, PDGF fusion proteins incorporated into fibrin foams.
  37. Lutolf, Matthias; Schense, Jason C.; Hubbell, Jeffrey A.; Jen, Anna, PTH containing cell growth matrix.
  38. Kausch, Annemie Rehor; Cerritelli, Simona, Polymeric tissue sealant.
  39. Rehor, Annemie; Cerritelli, Simona, Polymeric tissue sealant.
  40. Li, Xinfang; Worful, Jared M., Preparation of maytansinoid antibody conjugates by a one-step process.
  41. Li, Xinfang; Worful, Jared M., Preparation of maytansinoid antibody conjugates by a one-step process.
  42. Dai, Yong; Wang, Yong; Jin, Shengjin; Meshulam, Deborah H.; Amphlett, Godfrey W., Process for preparing purified drug conjugates.
  43. Wang, Yading; van Boxtel, Robert; Zhou, Stephen Q., Process for the modification of elastomers with surface interpenetrating polymer networks and elastomers formed therefrom.
  44. Wang Yading ; van Boxtel Robert,NLX ; Zhou Stephen Q., Process for the modification of elastomers with surface interpreting polymer networks and elastomers formed therefrom.
  45. Schense, Jason; Watson, John; Arrighi, Isabelle, Supplemented matrices for the repair of bone fractures.
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