[특허]Apparatus for magnetic cell separation

Apparatus for magnetic cell separation 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/553 B01L-011/00
출원번호	US-0212479 (1994-03-14)
발명자 / 주소	Moubayed Ahmad-Maher (Mission Viejo CA) Hardwick R. Alan (Lake Forest CA)
출원인 / 주소	Baxter International Inc. (Deerfield IL 02)
인용정보	피인용 횟수 : 94 인용 특허 : 0

초록 ▼

An apparatus for magnetic cell separation using paramagnetic microbeads includes a base upon which is movably carried a rocker member. The rocker member carries both a primary processing container in which a mixture of liquid with cells and paramagnetic microbeads is received; and a primary magnet movable from a first position adjacent to the primary container to magnetically capture the microbeads, and a second position spaced from the primary container to magnetically release the microbeads. The mixture of liquid with cells and microbeads is agitated by tilting motions of the rocker assembly, thereby achieving the binding of target cells to microbeads. The paramagnetic microbeads, with bound target cells, are captured and released by movements of the primary magnet between its first and second positions. A secondary magnet is placed downstream from the primary magnet to capture any paramagnetic microbeads which might escape from the primary magnet. Also provided is an interconnected container apparatus for use to contain and appropriately conduct the liquid, cells, and microbeads.

대표청구항 ▼

Apparatus for magnetic cell separation using paramagnetic microbeads and a container set including a primary container which is substantially of elongate cylindrical shade and a secondary container, which containers may be placed in fluid communication with one another, and which containers are magnetically permeable, said apparatus comprising: a base member, said base member movably supporting an agitation member, and first power drive means for agitating said agitation member relative to said base member; said agitation member including means for removably securing thereto in a relatively fixed secured position the primary container within which a liquid suspension of the cells and microbeads may be agitated by movement of said agitation member; said agitation member further movably carrying a primary magnet for movement between a first magnet position adjacent to the primary container in its secured position, in said first magnet position of said primary magnet magnetic flux penetrating the primary container in its secured position to attract and capture the microbeads, and said primary magnet being movable to a second magnet position spaced from the primary container in its secured position so that magnetic flux from said primary magnet does not capture the microbeads; and second power drive means for selectively moving said primary magnet between said first end second magnet positions independently of agitation of said primary container: wherein said base member further includes a holder for a secondary container, and a secondary magnet disposed adjacent to said secondary container when the latter is held on said holder for capturing paramagnetic microbeads which escape from said primary container; wherein said base member pivotally carries said agitation member; and wherein said agitation member is configured to secure thereto in a fixed relative position the primary container, said first power drive means also being effective to tiltingly move said agitation member and primary container between a first agitation member position in which the length of the primary container is vertical, and a second agitation member position in which the length of the primary container is horizontal.

이 특허를 인용한 특허 (94)

Chen Ching-Jen ; Haik Yousef ; Pai Vinay M., Apparatus for continuous magnetic separation of components from a mixture.
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Davis, Ronald W.; Jeffrey, Stefanie S.; Mindrinos, Michael N.; Pease, R. Fabian; Powell, Ashley Ann; Talasaz, AmirAli Hajhossein, Apparatus for magnetic separation of cells.
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Giesler Richard ; Chapman John R. ; Ellis Dale R. ; Bischof Daniel F., Apparatus for separation of biologic components from heterogeneous cell populations.
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Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Automated process for detecting the presence of a target nucleic acid in a sample.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Apparatus for magnetic cell separation 원문보기

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Apparatus for magnetic cell separation 원문보기

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