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Integrin-binding peptides 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-007/06
  • C07K-007/64
출원번호 US-0212186 (1994-03-11)
발명자 / 주소
  • Ruoslahti Erkki (Rancho Sante Fe CA) Koivunen Erkki (San Diego CA)
출원인 / 주소
  • La Jolla Cancer Research Foundation (02)
인용정보 피인용 횟수 : 54  인용 특허 : 0

초록

The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for a5b1 integrin. These peptides are characterized by having the ability to interfere with extracellular matrix protein binding to integrins; to block attachment o

대표청구항

A purified synthetic peptide consisting of an amino acid sequence selected from the group consisting of: CRGDCA (SEQ ID NO 26); GACRGDCLGA (SEQ ID NO 3); CVLNGRME (SEQ ID NO 13); NGRAHA (SEQ ID NO 4); DGRAHA (SEQ ID NO 11) and ALNGREESP (SEQ ID NO 6).

이 특허를 인용한 특허 (54)

  1. Arap,Wadih; Pasqualini,Renata, Aminopeptidase A (APA) targeting peptides for the treatment of cancer.
  2. Ruoslahti, Erkki; Pasqualini, Renata, Angiogenic homing molecules and conjugates derived therefrom.
  3. Zhang, Miqin; Veiseh, Mandana, Arrays and methods for guided cell patterning.
  4. Zhang, Miqin; Veiseh, Mandana, Arrays and methods for guided cell patterning.
  5. Lockhart, David J.; Zarrinkar, Patrick Parvis; Treiber, Daniel Kelly, Assays and kits for detecting protein binding.
  6. Ramakrishnan,Vanitha; Powers,David; Johnson,Dale E.; Jeffry,Ursula; Bhaskar,Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  7. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  8. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  9. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  10. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  11. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
  12. Pasqualini, Renata; Arap, Wadih; Kolonin, Mikhail G., Compositions and methods of use of targeting peptides against placenta and adipose tissues.
  13. Pasqualini, Renata; Arap, Wadih; Kolonin, Mikhail G., Compositions and methods of use of targeting peptides against placenta and adipose tissues.
  14. Pasqualini,Renata; Arap,Wadih; Kolonin,Mikhail G., Compositions and methods of use of targeting peptides against placenta and adipose tissues.
  15. Arap, Wadih; Kolonin, Mikhail G.; Mintz, Paul J.; Pasqualini, Renata; Zurita, Amado J., Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer.
  16. Arap, Wadih; Kolonin, Mikhail G.; Mintz, Paul J.; Pasqualini, Renata; Zurita, Amado J., Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer.
  17. Knudsen, Nina Østergaard; Thormann, Thorsten, Cyclic peptide and conjugate thereof for binding to keratinocytes.
  18. Cochran, Jennifer R.; Silverman, Adam P.; Kariolis, Mihalis S., Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use.
  19. Himmler, Gottfried; Mudde, Geert; Bauer, Anton; Redl, Gerda; Woisetschlager, Maximillian, Cytotoxic immunoglobulin.
  20. Himmler, Gottfried; Mudde, Geert; Bauer, Anton; Redl, Gerda; Woisetschlager, Maximillian, Cytotoxic immunoglobulin.
  21. Shachaf, Catherine M.; Shachaf, Amit, Diagnostic system for the detection of skin cancer.
  22. Himmler, Gottfried; Mudde, Geert; Redl, Gerda; Ruker, Florian; Wozniak-Knopp, Gordana, Display of binding agents.
  23. Cochran, Jennifer R.; Kimura, Richard H.; Levin, Aron M., Engineered integrin binding peptide compositions.
  24. Cochran, Jennifer R.; Kimura, Richard; Levin, Aron M., Engineered integrin binding peptides.
  25. Rubin, Jeffrey S.; Üren, Aykut; Cumberledge, Susan; Reichsman, Frieda, Fragments of secreted frizzled related protein.
  26. Ruoslahti, Erkki; Porkka, Kimmo; Christian, Sven, HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells.
  27. Ruoslahti, Erkki; Porkka, Kimmo; Christian, Sven, HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells.
  28. Ruoslahti, Erkki; Porkka, Kimmo; Christian, Sven, HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells.
  29. Ruoslahti, Erkki; Porkka, Kimmo; Christian, Sven, HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells.
  30. Arap, Wadih; Pasqualini, Renata, Human and mouse targeting peptides identified by phage display.
  31. Cochran, Jennifer R.; Kimura, Richard; Gambhir, Sanjiv S.; Cheng, Zhen, Imaging methods using engineered integrin binding peptides.
  32. Corti, Angelo; Curnis, Flavio, Immunoconjugates for the treatment of tumours.
  33. Corti, Angelo; Curnis, Flavio, Immunoconjugates for the treatment of tumours.
  34. Ruoslahti Erkki ; Koivunen Erkki, Integrin-binding peptides.
  35. Liu, Shuang, Macrocyclic chelants for metallopharmaceuticals.
  36. Epstein, David L.; Lee, Paul P.; Rao, Vasanth, Method of preventing or treating glaucoma.
  37. McKearn, John P.; Gordon, Gary; Cunningham, James J.; Gately, Stephen T.; Koki, Alane T.; Masferrer, Jaime L., Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia.
  38. Varner, Judith A., Methods for detecting and inhibiting angiogenesis.
  39. Varner, Judith A., Methods for detecting and inhibiting angiogenesis.
  40. Varner,Judith A., Methods for detecting and inhibiting angiogenesis.
  41. Schwartz Martin A. ; Meredith ; Jr. Jere E. ; Takada Yoshikazu ; Languino Lucia, Methods of use for integrin B.sub.1C cell growth inhibitor.
  42. Rubin, Jeffrey S.; Cumberledge, Susan; Reichsman, Frieda; Uren, Aykut, Methods of use of fragments of secreted frizzled related protein, sFRP.
  43. Burg, Michael A.; Pasqualini, Renata; Arap, Wadih; Ruoslahti, Erkki; Stallcup, William B., NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods.
  44. Erkki Ruoslahti ; Renata Pasqualini, NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same.
  45. Ruoslahti Erkki ; Pasqualini Renata, NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same.
  46. Arap, Wadih; Pasqualini, Renata, Peptide compositions for targeting adipose tissue.
  47. Corti, Angelo; Curnis, Flavio, Peptides comprising an isoDGR motif.
  48. Rubin,Jeffrey S.; ��ren,Aykut; Gillespie,Matthew Todd; Horwood,Nicole Joy, SFRP and peptide motifs that interact with SFRP and methods of their use.
  49. Ruoslahti Erkki ; Pasqualini Renata, Structural mimics of RGD-binding sites.
  50. Ruoslahti Erkki ; Pasqualini Renata, Structural mimics of RGD-binding sites.
  51. Ruker, Florian; Himmler, Gottfried; Wozniak-Knopp, Gordana, Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions.
  52. Unger,Evan C.; Matsunaga,Terry O.; Schumann,Patricia A., Targeted compositions for diagnostic and therapeutic use.
  53. Ramakrishnan, Vanitha; Bhaskar, Vinay; Ho, Sun; Murray, Richard; Law, Debbie, Use of anti-α5β1 antibodies to inhibit cancer cell proliferation.
  54. Rubin, Jeffrey S.; Üren, Aykut; Kay, Brian K.; Weisblum, Bernard; Gillespie, Matthew Todd; Horwood, Nicole Joy, sFRP and peptide motifs that interact with sFRP and methods of their use.
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