초록 ▼

Systems and methods are provided for reducing the number of leukocytes in cellular products like platelets collected in an on line or continuous blood separation processes. The systems and methods reduce the number of leukocytes from a cellular suspension before its separation into a cellular-rich c

Systems and methods are provided for reducing the number of leukocytes in cellular products like platelets collected in an on line or continuous blood separation processes. The systems and methods reduce the number of leukocytes from a cellular suspension before its separation into a cellular-rich concentration. This leads to effective and efficient leukocyte removal and a high quality blood product suited for therapeutic use, with and without long term storage.

대표청구항 ▼

A method for obtaining a platelet-rich concentrate having a reduced number of leukocytes comprising introducing whole blood from a source at a selected first pumping rate into a first separation chamber, the whole blood having a surface hematocrit when introduced into the first separation chamber, s

A method for obtaining a platelet-rich concentrate having a reduced number of leukocytes comprising introducing whole blood from a source at a selected first pumping rate into a first separation chamber, the whole blood having a surface hematocrit when introduced into the first separation chamber, separating the whole blood in the first separation chamber into a suspension of platelets, conveying the suspension of platelets through a filter at a selected second pumping rate less than the first pumping rate from the first separation chamber into a second separation chamber to reduce the number of leukocytes, separating the filtered suspension of platelets in the second separation chamber into a platelet-rich concentrate and platelet-poor component, diverting a portion of the suspension of platelets from the first separation chamber at a third selected pumping rate prior to filtration, mixing the diverted portion with whole blood introduced into the first separation chamber, and controlling the third selected pumping rate to maintain the surface hematocrit of whole blood introduced into the first separation chamber within a predetermined desired range.