[특허]Solid depot drug form

Solid depot drug form 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/20
출원번호	US-0125133 (1993-09-23)
우선권정보	DE-4138513 (1991-11-23)
발명자 / 주소	Mueller Winfried (Mannheim DEX) Spengler Reinhard (Ludwigshafen DEX) Grabowski Sven (Ludwigshafen DEX) Sanner Axel (Frankenthal DEX)
출원인 / 주소	BASF Aktiengesellschaft (Ludwigshafen DEX 03)
인용정보	피인용 횟수 : 62 인용 특허 : 0

초록 ▼

A solid depot drug form produced by melt extrusion at from 50°to 200°C. and continuous shaping of a mixture of from 0.1 to 70% by weight, based on the finished depot form, of a pharmaceutical active ingredient with a polymer melt of the following composition: a) at least 6% by weight, based on the complete depot form, of at least one water-insoluble poly(meth) acrylate with a glass transition temperature Tg in the range from -60°to 180°C., b) a water-soluble hydroxyalkylcellulose or hydroxy-alkylmethylcellulose with 2 or 3 carbons in the hydroxyalkyl, or an N-vinylpyrrolidone polymer with from 0 to 50% by weight of vinyl acetate or a mixture of the two in the ratio a):b) =5:95 to 95:5, and c) 0-30% by weight, based on the finished depot form, of one or more conventional pharmaceutical auxiliaries.

대표청구항 ▼

A process for the production of a solid depot drug form which comprises melt extruding at from 50°to 200°C. and hot cut pelletizing a mixture of from 0.1 to 70% by weight, based on the finished depot form, of a pharmaceutically active ingredient with a polymer melt of the following composition: (a) At least 6% by weight, based on the complete depot form, of a extrudable water-insoluble poly(meth)acrylate with a glass transition temperature Tg in the range from -60°to 180°C., and (b) A polymer which is (1′) a water-soluble hydroxyalkylcellulose or (1″) hydroxyalkylmethylcellulose with 2 or 3 carbons in the hydroxyalky, or (2) an N-vinylpyrrolidone polymer with from 0 to 50% by weight of vinyl acetate or (3) a mixture of b(1′) or b(1″) and b(2) wherein polymer (b) is present in an amount of 5% to 95% of the weight of (a) and (b), and (c) 0-30% by weight, based on the finished depot form, of one or more conventional pharmaceutical auxiliaries, the said extrudable water-insoluble poly(meth)acrylate having a solubility of less than 10 mg in one liter of water at 20°C.

이 특허를 인용한 특허 (62)

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Bartholomaeus, Johannes; Kugelmann, Heinrich, Abuse-proofed dosage form.
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Oshlack Benjamin ; Chasin Mark ; Huang Hua-Pin, Extruded orally administrable opioid formulations.
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Barnscheid, Lutz; Galia, Eric, Hot-melt extruded pharmaceutical dosage form.
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McGinity, James W.; Schilling, Sandra U., Hot-melt extrusion of modified release multi-particulates.
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McGinity, James W.; Schilling, Sandra U., Hot-melt extrusion of modified release multi-particulates.
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Fort, James J.; Krill, Steven L.; Law, Devalina; Qiu, Yihong; Schmitt, Eric A., Inhibitors of crystallization in a solid dispersion.
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Fritz, Ulf; Fritz, Olaf; Gordy, Thomas A.; Wojcik, Ronald; Blümmel, Jacques; Küller, Alexander, Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same.
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Fritz, Ulf; Fritz, Olaf; Gordy, Thomas A.; Wojcik, Ronald; Blümmel, Jacques; Küller, Alexander, Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same.
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Oshlack Benjamin ; Chasin Mark ; Huang Hua-Pin ; Sackler David, Melt-extruded orally administrable opioid formulations.
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Oshlack, Benjamin; Chasin, Mark; Huang, Hua-Pin; Sackler, David, Melt-extruded orally administrable opioid formulations.
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Benjamin Oshlack ; Hua-Pin Huang ; Mark Chasin, Melt-extrusion multiparticulates.
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Oshlack, Benjamin; Chasin, Mark; Huang, Hua-Pin, Melt-extrusion multiparticulates.
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Oshlack,Benjamin; Chasin,Mark; Huang,Hua Pin, Melt-extrusion multiparticulates.
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Rein, Hubert; Steffens, Klaus-Jurgen, Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix.
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Barnscheid, Lutz; Wening, Klaus; Pätz, Jana; Geissler, Anja, Multiparticles safeguarded against ethanolic dose-dumping.
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Kanikanti, Venkata-Rangarao; Rupp, Roland; Brendel, Erich; Weisemann, Claus; Chantraine, Ernst, Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same.
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Hayes, Geoffrey Gerard; Mohammad, Hassan; Tamber, Harjit; Walden, Malcolm; Whitelock, Steve; Danagher, Helen Kathleen; Prater, Derek Allan, Particulates.
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Leslie Stewart Thomas,GBX ; Knott Trevor John,GBX ; Mohammad Hasssan,GBX ; Prater Derek Allan,GBX, Pharmaceutical composition containing a fusible carrier and method for producing the same.
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Jans, Eugeen Marie Jozef; Kiekens, Filip René Irena; Voorspoels, Jody Firmin Marceline; Faure, Anne; Ziegler, Iris; Arkenau-Maric, Elisabeth; Barnscheid, Lutz; Bartholomäus, Johannes; Frevel, Marc; Galia, Eric; Schüessele, Andrea, Pharmaceutical dosage form.
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McAllister, Stephen Mark; Raby, Jr., Ronald K.; Brown, Adrian; Clarke, Allan J., Pharmaceutical formulation.
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McAllister, Stephen Mark; Raby, Jr., Ronald K.; Brown, Adrian; Clarke, Allan J., Pharmaceutical formulation.
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McAllister, Stephen Mark; Raby, Jr., Ronald K.; Brown, Adrian; Clarke, Allan J.; Matthews, Wayne; Margetson, Daniel N., Pharmaceutical formulation.
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Brown, Adrian; Matthews, Wayne M.; Margetson, Daniel M.; McAllister, Stephen Mark; Raby, Ronald K., Pharmaceutical formulations.
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McAllister, Stephen Mark; Raby, Jr., Ronald K.; Brown, Adrian, Pharmaceutical formulations.
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Grunze,Michael; Gries,Claudia, Poly-tri-fluoro-ethoxypolyphosphazene coverings and films.
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Kothrade,Stephan; Berndl,Gunther; Simon,Dirk; Sanner,Axel, Process for producing solid dosage forms.
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Kothrade,Stephan; Berndl,Gunther; Simon,Dirk; Sanner,Axel, Process for producing solid dosage forms.
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Breitenbach Jorg,DEX ; Kleinke Andreas,DEX ; Kothrade Stephan,DEX ; Rosenberg Joerg,DEX, Process for producing solid dosage forms by extrusion.
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Zeidler Jurgen,DEX ; Rosenberg Joerg,DEX ; Breitenbach Jorg,DEX ; Kleinke Andreas,DEX ; Maier Werner,DEX, Process for producing solid drug forms having at least two phases.
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Faure, Anne; Voorspoels, Jody Firim Marceline; Mertens, Roel Jos M.; Kiekens, Filip René Irena, Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet.
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Berndl, Gunther; Breitenbach, Jörg; Heger, Robert; Stadler, Michael; Wilke, Peter; Rosenberg, Jörg, Self-emulsifying active substance formulation and use of this formulation.
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Berndl, Gunther; Breitenbach, Jörg; Heger, Robert; Stadler, Michael; Wilke, Peter; Rosenberg, Jörg, Self-emulsifying active substance formulation and use of this formulation.
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Grabowski Sven,DEX ; Rosenberg Joerg,DEX ; Sanner Axel,DEX, Slow-release matrix pellets and the production thereof.
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Fort,James J.; Krill,Steven L.; Law,Devalina; Qiu,Yihong; Porter,William R.; Schmitt,Eric A., Solid dispersion pharamaceutical formulations.
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Berndl, Gunther; Rosenberg, Joerg; Liepold, Bernd; Breitenbach, Joerg; Reinhold, Ulrich; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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Rosenberg, Jeorg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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Rosenberg, Joerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Joerg; Alani, Laman; Ghosh, Soumojeet, Solid pharmaceutical dosage form.
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Rosenberg, Jöerg; Reinhold, Ulrich; Liepold, Bernd; Berndl, Gunther; Breitenbach, Jörg; Alani, Laman L.; Ghosh, Soumojeet, Solid pharmaceutical dosage formulation.
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Grunze, Michael; Fritz, Ulf, Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface.
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Barnscheid, Lutz; Schwier, Sebastian; Bartholomäus, Johannes, Tamper resistant dosage form comprising an anionic polymer.
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Barnscheid, Lutz; Geiβler, Anja; Wening, Klaus; Strauch, Stefanie; Pätz, Jana; Schwier, Sebastian, Tamper resistant dosage form with bimodal release profile.
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Friedrich, Ingo; Fuhrherr, Richard; Möschter, Silke; Wengner, Simone, Tamper resistant immediate release capsule formulation comprising tapentadol.
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Barnscheid, Lutz; Redmer, Jessica; Schwier, Sebastian, Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer.
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Barnscheid, Lutz; Geiβler, Anja; Wening, Klaus; Pätz, Jana, Tamper-resistant dosage form containing one or more particles.
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Wening, Klaus; Geiβler, Anja; Denker, Jana; Barnscheid, Lutz, Tamper-resistant dosage form with immediate release and resistance against solvent extraction.
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Schwier, Sebastian; Haupts, Marcel; Barnscheid, Lutz; Pätz, Jana, Tamper-resistant tablet providing immediate drug release.
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Barnscheid, Lutz; Galia, Eric; Geißler, Anja; Pätz, Jana; Schwier, Sebastian; Baronsky-Probst, Julia, Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc.
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Bouillo, Nathalie; Pierobon, Marianna; Widmaier, Ralf; Dobrawa, Rainer; Meyer-Böhm, Kathrin; Lange, Ronald Frans-Maria, Use of a copolymer in the form of a solubiliser for a poorly water-soluble compound.
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Bouillo, Nathalie; Pierobon, Marianna; Widmaier, Ralf; Dobrawa, Rainer; Meyer-Boehm, Kathrin; Lange, Ronald Frans-Maria, Use of copolymers as solubilizers for slightly water-soluble compounds.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Solid depot drug form 원문보기

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Solid depot drug form 원문보기

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이 특허를 인용한 특허 (62)

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