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Use of polyols for improving the introduction of genetic material into cells 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-063/00
  • C12N-005/00
  • C12N-015/00
출원번호 US-0315974 (1994-09-30)
발명자 / 주소
  • March Keith L. (Carmel IN)
출원인 / 주소
  • Indiana University Foundation (Bloomington IN 02)
인용정보 피인용 횟수 : 41  인용 특허 : 0

초록

A process for introducing an expression vehicle (e.g., plasmids, retroviral vectors, adenoviral vectors) into cells, which comprises contacting the cells with the expression vehicle and a polyol. The polyol may be a polyoxalkylene block copolymer, such as a polyoxypropylene-polyoxyethylene block cop

대표청구항

In a process for transfecting a cell with a viral particle, the improvement comprising: contacting said cell with a composition comprising said viral particle and a non-ionic polyol, said non-ionic polyol being a polyoxyalkylene block copolymer wherein the alkylene moieties of the polyoxyalkylene gr

이 특허를 인용한 특허 (41)

  1. Arnold, John Jefferson; Huang, Chun Ming; Meezan, Elias; Pillion, Dennis J.; Tang, De Chu C., Alkyl-glycoside enhanced vaccination.
  2. Kiser, Patrick F.; Thomas, Allen A., Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments.
  3. Welsh Michael J. ; Fasbender Allen J., Complexes of adenovirus with cationic molecules.
  4. Engler, Heidrun; Nagabhushan, Tattanahalli L.; Youngster, Stephen Kenneth, Compositions and methods for enhancing delivery of therapeutic agents to cells.
  5. Manthorpe, Marston; Hartikka, Jukka; Sukhu, Loretta; Meek, Jennifer, Compositions and methods for in vivo delivery of polynucleotide-based therapeutics.
  6. Engler Heidrun ; Maneval Dan, Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems.
  7. Heidrun Engler ; Maneval Dan, Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems.
  8. Engler Heidrun ; Huyghe Bernard G. ; Maneval Daniel C. ; Shabram Paul, Compositions and methods for therapeutic use.
  9. Engler, Heidrun; Nagabhushan, Tattanahalli L.; Youngster, Stephen Kenneth, Compositions and methods for therapeutic use.
  10. Engler, Heidrun; Nagabhushan, Tattanahalli L.; Youngster, Stephen Kenneth, Compositions and methods for therapeutic use.
  11. Engler,Heidrun; Nagabhushan,Tattanahalli L.; Youngster,Stephen Kenneth, Compositions and methods for therapeutic use.
  12. Heidrun Engler ; Tattanahalli L. Nagabhushan ; Stephen Kenneth Youngster, Compositions for enhancing delivery of nucleic acids to cells.
  13. Rolland, Allain; Mumper, Russell J., Formulated nucleic acid compositions and methods of administering the same for gene therapy.
  14. Wu, Zheng; Zhang, Shuyuan, Formulation for adenovirus storage.
  15. Wu, Zheng; Zhang, Shuyuan, Formulation of adenovirus for gene therapy.
  16. Wu,Zheng; Zhang,Shuyuan, Formulation of adenovirus for gene therapy.
  17. Terada,Masaaki; Ochiya,Takahiro; Miyata,Teruo; Itoh,Hiroshi, Gene preparations.
  18. Shu Chien ; John Y-J Shyy, Gene therapy in coronary angioplasty and bypass.
  19. Wu, Zheng; Zhang, Shuyuan, Liquid adenovirus formulations.
  20. Hoeben Robert Cornelis,NLX ; Bout Abraham,NLX, Method for intracellular DNA amplification.
  21. Pham, Hai; Zhang, Shuyuan; Clarke, Peter, Method for the production and purification of adenoviral vectors.
  22. Zhang, Shuyuan; Thwin, Capucine; Wu, Zheng; Cho, Toohyon; Gallagher, Shawn, Method for the production and purification of adenoviral vectors.
  23. Zhang,Shuyuan; Thwin,Capucine; Wu,Zheng; Cho,Toohyon; Gallagher,Shawn, Method for the production and purification of adenoviral vectors.
  24. Zhang,Shuyuan; Thwin,Capucine; Wu,Zheng; Cho,Toohyon; Wilson,Deborah; Caston,Lucetta, Method for the production and purification of adenoviral vectors.
  25. Barsoum, James G.; Qin, Xiao-Qiang, Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta.
  26. Barsoum,James G; Qin,Albert X, Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta.
  27. Benedict, William F., Methods and compositions for treatment of interferon-resistant tumors.
  28. Benedict, William F., Methods and compositions for treatment of interferon-resistant tumors.
  29. Zhang,Shuyuan; Thwin,Capucine; Wu,Zheng; Cho,Toohyon; Wilson,Deborah; Caston,Lucetta, Methods for producing purified adenoviral vectors.
  30. Scanlin Thomas F. ; Glick Mary Catherine ; Kollen Wouter J.W., Non-viral vehicles for use in gene transfer.
  31. De-chu C. Tang ; Donald H. Marks ; David T. Curiel ; Zhongkai Shi ; Kent Rigby van Kampen, Noninvasive genetic immunization, expression products therefrom and uses thereof.
  32. Tang, De-chu C.; Marks, Donald H.; Curiel, David T.; Shi, Zhongkai, Noninvasive genetic immunization, expression products therefrom, and uses thereof.
  33. Glen S. Kwon ; Bong K. Yoo, Nystatin formulation having reduced toxicity.
  34. Kabanov Alexander V. ; Alakov Valery Y.,CAX ; Vinogradov Sergey V., Polynucleotide compositions.
  35. Pierre M. Lemieux CA; Alexander V. Kabanov ; Valery Y. Alakov CA; Sergey V. Vinogradov, Polynucleotide compositions for intramuscular administration.
  36. Connor,Robert; McAuliffe,Joseph, Transfection agents.
  37. Smith, Alan E.; O'Riordan, Catherine R.; Francis, Gillian E.; Parkes, Vincent; Delgado, Christina, Tresyl-monomethoxypolyethylene glycol-modified viruses having viral infectivity.
  38. Fick James R., Tumor delivery vehicles.
  39. James R. Fick, Tumor delivery vehicles.
  40. Neufeld Gera,ILX ; Keshet Eli,ILX ; Vlodavsky Israel,ILX ; Poltorak Zoya,ILX, VEGF.sub.145 expression vectors.
  41. Tang, De-chu; Marks, Donald H.; Curiel, David T.; Shi, Zhongkai, Vaccination by topical application of genetic vectors.
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