[특허]Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies

Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-035/16
출원번호	US-0946421 (1992-11-06)
우선권정보	EP-1933892 (1991-03-06)
국제출원번호	PCT/EP92/00480 (1992-03-04)
§371/§102 date	19921106 (19921106)
국제공개번호	WO-9215683 (1992-09-17)
발명자 / 주소	Bendig Mary M. (London GBX) Kettleborough Catherine A. (Herts GBX) Saldanha Jose (Middlesex GBX)
출원인 / 주소	Merck Patent Gesellschaft Mit Beschrankter Haftung (Darmstadt DEX 03)
인용정보	피인용 횟수 : 195 인용 특허 : 0

초록 ▼

Humanized and chimeric anti-epidermal growth factor receptor (anti-EGF-R) monoclonal antibodies are disclosed, comprising an artificial modified consensus sequence for the heavy chain of the framework region of the variable region of a human immunoglobulin. Corresponding humanized and chimeric monoclonal antibodies which bind to epitopes of the epidermal growth factor receptor (EGF-R) having specific amino acid sequences in the hypervariable regions responsible for EGF-R binding are also disclosed. These antibodies are therapeutically and diagnostically useful.

대표청구항 ▼

A humanized antibody, comprising a variable region and a constant region, wherein the hypervariable region of the light chain CDRs has the following amino acid sequences: ________________________________ - CDR-1 Ser－Ala－Ser－Ser－Ser－Val－Thr－Tyr－Met－Tyr (SEQ ID NO:1), CDR-2 Asp－Thr－Ser－Asn－Leu－Ala－Ser (SEQ ID NO:2) and CDR-3 Gln－Gln－Trp－Ser－Ser－His－Ile－Phe－Thr (SEQ ID NO:3); ________________________________ the hypervariable region of the heavy chain CDRs has the following amino acid sequences: ________________________________ - CDR-1 Ser－His－Trp－Met－His (SEQ ID NO:4), CDR-2 Glu－Phe－Asn－Pro－Ser－Asn－Gly－Arg－Thr－Asn－ Tyr－Asn－Glu－Lys－Phe－Lys－Ser (SEQ ID NO:5) and CDR-3 Arg－Asp－Tyr－Asp－Tyr－Asp－Gly－Arg－Tyr－ Phe－Asp－Tyr (SEQ ID NO:6); ________________________________ the light chain framework region has the following amino acid sequences: ________________________________ - FR-1 Asp－Ile－Gln－Met－Thr－Gln－Ser－Pro－Ser－ Ser－Leu－Ser－Ala－Ser－Val－Gly－Asp－Arg－Val－ Thr－Ile－Thr－Cys (SEQ ID NO:7), FR-2 Trp－Tyr－Gln－Gln－Lys－Pro－Gly－Lys－Ala－ Pro－Lys－Leu－Leu－Ile－Tyr (SEQ ID NO:8), FR-3 Gly－Val－Pro－Ser－Arg－Phe－Ser－Gly－Ser－ Gly－Ser－Gly－Thr－Asp－Xaa1－Thr－Phe－Thr－ Ile－Ser－Ser－Leu－Gln－Pro－Glu－Asp－Ile－Ala－ Thr－Tyr－Tyr－Cys (SEQ ID NO:9) and FR-4 Phe－Gly－Gln－Gly－Thr－Lys－Val－Glu－Ile－Lys (SEQ ID NO:10); ________________________________ the heavy chain framework region has the following amino acid sequences: ________________________________ - FR-1 Gln－Val－Gln－Leu－Val－Gln－Ser－Gly－Ala－Glu－ Val－Lys－Lys－Pro－Gly－Ala－Ser－Val－Lys－Val－ Ser－Cys－Lys－Ala－Ser－Gly－Tyr－Thr－Phe－Xaa2 (SEQ ID NO:11), FR-2 Trp－Val－Xaa3－Gln－Xaa4－Xaa5－Gly－Gln－Gly－ Leu－Glu－Trp－Xaa6－Gly (SEQ ID NO:12), FR-3 Xaa7－Xaa8－Thr－Met－Thr－Xaa9－Asp－Thr－Ser－ Thr－Asn－Thr－Ala－Tyr－Met－Xaa10－Leu－Ser－Ser－ Leu－Arg－Ser－Glu－Asp－Thr－Ala－Val－Tyr－Tyr－ Cys－Ala－Ser (SEQ ID NO:13) and Fr-4 Trp－Gly－Gln－Gly－Thr－Leu－Val－Thr－Val－Ser－ Ser (SEQ ID NO:14); ________________________________ wherein Xaa1 is Tyr, Phe, Trp or His; Xaa2 is Thr or Ser; Xaa3 is Arg or His; Xaa4 is Ala, Lys or His; Xaa5 is Pro or Val; Xaa6 is Ile, Val or Leu; Xaa7 is Lys, Arg or His; Xaa8 is Ala, Val, Pro or Gly; Xaa9 is Val, Ala, Pro or Gly; and Xaa10 is Glu or Asn; and wherein said humanized antibody binds to human EGF receptors, and inhibits binding of EGF to EGF-receptor.

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Wu, Chengbin; Ambrosi, Dominic J.; Hsieh, Chung-ming; Ghayur, Tariq, IL-1 binding proteins.
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Hsieh, Chung-Ming; Hugunin, Margaret; Kutskova, Yuliya; Memmott, John E.; Perez, Jennifer M.; Zhong, Suju; Tarcsa, Edit; Clabbers, Anca, IL-17 binding proteins.
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Hsieh, Chung-Ming; Hugunin, Margaret; Murtaza, Anwar; McRae, Bradford L.; Kutskova, Yuliya; Memmott, John E.; Perez, Jennifer M.; Zhong, Suju; Tarcsa, Edit; Clabbers, Anca; Wallace, Craig; Bryant, Shaughn H.; Leddy, Mary R., IL-17 binding proteins.
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Hsieh, Chung-Ming; Hugunin, Margaret; Murtaza, Anwar; McRae, Bradford L.; Kutskova, Yuliya; Memmott, John E.; Perez, Jennifer M.; Zhong, Suju; Tarcsa, Edit; Clabbers, Anca; Wallace, Craig; Bryant, Shaughn H.; Leddy, Mary R., IL-17 binding proteins.
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Hsieh, Chung-Ming; Hugunin, Margaret; Murtaza, Anwar; McRae, Bradford L.; Kutskova, Yuliya; Memmott, John E.; Perez, Jennifer M.; Zhong, Suju; Tarcsa, Edit; Clabbers, Anca; Wallace, Craig; Bryant, Shaughn H.; Leddy, Mary R., IL-17 binding proteins.
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Hsieh, Chung-Ming; Hugunin, Margaret; Murtaza, Anwar; McRae, Bradford L.; Kutskova, Yuliya; Memmott, John E.; Perez, Jennifer M.; Zhong, Suju; Tarcsa, Edit; Clabbers, Anca; Wallace, Craig; Bryant, Shaughn H.; Leddy, Mary R., IL-17 binding proteins.
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Wu, Chengbin; Ambrosi, Dominic J.; Hsieh, Chung-ming; Ghayur, Tariq, IL-I binding proteins.
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Lazar, Gregory A.; Dahiyat, Bassil I.; Dang, Wei; Karki, Sher Bahadur; Vafa, Omid, Immunoglobulin insertions, deletions and substitutions.
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Yusibov, Vidadi; Mett, Vadim; Musiychuck, Konstantin, Influenza antigens, vaccine compositions, and related methods.
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Yusibov, Vidadi; Mett, Vadim; Chichester, Jessica; Goldschmidt, Lauren, Influenza hemagglutinin antibodies, compositions and related methods.
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Yusibov, Vidadi; Mett, Vadim; Chichester, Jessica; Goldschmidt, Lauren, Influenza hemagglutinin antibodies, compositions and related methods.
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Benatuil, Lorenzo; Deng, Kangwen; Hanzatian, Denise Karaoglu; Argiriadi, Maria A., LRP-8 binding dual variable domain immunoglobulin proteins.
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Tomlinson, Ian; Jespers, Laurent; Clube, Jasper; Holt, Lucy J.; Schon, Oliver, Ligand.
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Ignatovich, Olga; Holmes, Steve; Beckmann, Roland; de Wildt, Rudolf M. T., Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor.
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Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
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Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
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Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
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Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
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Paul J. Carter ; Leonard G. Presta, Method for making humanized antibodies.
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Setiady, Julianto; Park, Peter U.; Chittenden, Thomas, Method of treatment of tumors that are resistant to EGFR antibody therapies by EGFR antibody cytotoxic agent conjugate.
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Dong, Haidong; Kwon, Eugene D.; Markovic, Svetomir N.; Krco, Christopher J., Methods and materials for treating cancer.
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Dong, Haidong; Harrington, Susan M.; Kwon, Eugene D.; Krco, Christopher J.; Liu, Xin, Methods for treating cancer in patients with elevated levels of BIM.
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Ellies, Debra L., Methods of altering bone growth by administration of sost or wise antagonist or agonist.
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Ellies, Debra L., Methods of altering bone growth by administration of sost or wise antagonist or agonist.
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Desai, Neil P.; Soon-Shiong, Patrick, Methods of treating cancer.
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Desai, Neil P.; Soon-Shiong, Patrick, Methods of treating cancer.
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Fox, Irving H.; Scholz, Catherine, Methods of treating ulcerative colitis.
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Fox, Irving H.; Scholz, Catherine, Methods of treating ulcerative colitis.
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Desai, Neil P.; Soon-Shiong, Patrick, Methods of treatment of pancreatic cancer.
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Desai, Neil P.; Soon-Shiong, Patrick, Methods of treatment of pancreatic cancer.
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Desai, Neil P.; Soon-Shiong, Patrick, Methods of treatment of pancreatic cancer.
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Pedersen, Mikkel Wandahl; Kragh, Michael; Hey, Adam S.; Jacobsen, Helle, Methods using recombinant anti-epidermal growth factor receptor antibody compositions.
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Desjarlais, John R.; Karki, Sher Bahadur; Lazar, Gregory Alan; Richards, John O.; Moore, Gregory L.; Carmichael, David F., Modified FC molecules.
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Carr,Francis J.; Carter,Graham; Jones,Tim; Williams,Stephen; Hamilton,Anita, Modified anti-EGFR antibodies with reduced immunogenicity.
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Bernett, Matthew; Chu, Seung; Wickramarachichi, Dilki; Desjarlais, John, Modulation of T cells with bispecific antibodies and FC fusions.
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Taylor, Alexander H., Monoclonal antibodies with reduced immunogenicity.
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Johns, Terrance Grant; Stockert, Elizabeth; Old, Lloyd J.; Scott, Andrew M.; Rayzman, Veronika M., Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof.
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Briskin, Michael J., Mucosal vascular addressins and uses thereof.
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Setiady, Julianto; Singh, Rajeeva; Park, Peter U.; Rui, Lingyun; Chittenden, Thomas, Non-antagonistic EGFR-binding molecules and immunoconjugates thereof.
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Lazar, Gregory Alan; Chirino, Arthur J.; Dang, Wei; Desjarlais, John R.; Doberstein, Stephen K.; Hayes, Robert J.; Karki, Sher Bahadur; Vafa, Omid, Optimized Fc variants and methods for their generation.
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Lazar, Gregory Alan; Chirino, Arthur J.; Dang, Wei; Desjarlais, John R.; Doberstein, Stephen Kohl; Hayes, Robert J.; Karki, Sher Bahadur; Vafa, Omid, Optimized Fc variants and methods for their generation.
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Moore, Gregory; Bernett, Matthew; Rashid, Rumana; Desjarlais, John, Optimized antibody variable regions.
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Kreysch, Hans Georg; Schmidt, Juergen, Pharmaceutical compositions directed to Erb-B1 receptors.
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Bertozzi, Carolyn; Agarwal, Paresh; Sletten, Ellen M., Pictet-Spengler ligation for protein chemical modification.
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Steward, Michael; Pupecka, Malgorzata; Tomlinson, Ian; Enever, Carolyn; Jespers, Laurent; Batuwangala, Thil Dinuk, Polypeptides, antibody variable domains and antagonists.
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Nadel, Jay A.; Takeyama, Kiyoshi, Preventing airway mucus production by administration of EGF-R antagonists.
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Wolfgang Strittmatter DE; Siegfried Matzku DE; Dieter Riesenberg DE; Uwe Horn DE; Uwe Knupeer DE; Marian Kujau DE; Rolf Wenderoth DE; Andreas Pluckthun CH; Anke Krebber CH, Process for the preparation of recombinant proteins in E. coli by high cell density fermentation.
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Yusibov, Vidadi; Mett, Vadim; Rabindran, Shailaja; Shamloul, Moneim; Ensley, Burt, Production of foreign nucleic acids and polypeptides in sprout systems.
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Ensley, Burt D.; Yusibov, Vidadi, Production of pharmaceutically active proteins in sprouted seedlings.
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Ghayur, Tariq; Gu, Jijie; Isakson, Peter C., Prostaglandin E2 dual variable domain immunoglobulins and uses thereof.
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Moore, Gregory L.; Desjarlais, John; Bernett, Matthew, Rapid clearance of antigen complexes using novel antibodies.
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Pedersen, Mikkel Wandahl; Steinaa, Lucilla; Jensen, Allan; Koefoed, Klaus; Meijer, Per-Johan; Carlsson, Robert; Pyke, Charles; Nielsen, Lars Sogaard, Recombinant anti-epidermal growth factor receptor antibody compositions.
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Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Recombinant carrier molecule for expression, delivery and purification of target polypeptides.
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Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Recombinant carrier molecule for expression, delivery and purification of target polypeptides.
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Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Recombinant carrier molecule for expression, delivery and purification of target polypeptides.
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Srivastava,Arun; Qing,Keyun; Wang,Xu Shan; Ponnazhagan,Selvarangan; Bajpai,Anil, Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression.
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Old, Lloyd J.; Ritter, Gerd; Jungbluth, Achim; Stockert, Elisabeth; Cavenee, Webster K., Specific binding proteins and uses thereof.
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Old, Lloyd J.; Ritter, Gerd; Jungbluth, Achim; Stockert, Elisabeth; Cavenee, Webster K., Specific binding proteins and uses thereof.
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Ritter, Gerd; Murray, Anne; Mark, George; Renner, Christoph, Specific binding proteins and uses thereof.
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Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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Yusibov, Vidadi; Skarjinskaia, Marina, Systems and methods for clonal expression in plants.
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Yashwant M. Deo ; Joel Goldstein ; Robert Graziano ; Chezian Somasundaram, Therapeutic compounds comprised of anti-Fc receptor antibodies.
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Yashwant M. Deo ; Joel Goldstein ; Robert Graziano ; Chezian Somasundaram, Therapeutic compounds comprised of anti-Fc receptor antibodies.
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Rose,William C., Therapeutic synergy of anti-cancer compounds.
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Jakobovits, Aya; Kucherlapati, Raju; Klapholz, Sue; Mendez, Michael J.; Green, Larry, Transgenic mammals having human IG loci including plural Vand Vregions and antibodies produced therefrom.
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Jakobovits, Aya; Kucherlapati, Raju; Klapholz, Susan; Mendez, Michael J; Green, Larry, Transgenic mammals having human Ig loci including plural VH and Vκ regions and antibodies produced therefrom.
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Johns, Terrance Grant; Cavenee, Webster; Furnari, Frank; Scott, Andrew, Treatment method using EGFR antibodies and SRC inhibitors and related formulations.
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Ringler, Douglas J.; Picarella, Dominic; Newman, Walter, Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam.
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Knapp, Elisabeth; Yusibov, Vidadi, Trypanosoma antigens, vaccine compositions, and related methods.
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Wong, Kwok-Kin, Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease.
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Ramakrishnan, Vanitha; Bhaskar, Vinay; Ho, Sun; Murray, Richard; Law, Debbie, Use of anti-α5β1 antibodies to inhibit cancer cell proliferation.
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Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Yersinia pestis antigens, vaccine compositions, and related methods.
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Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Yersinia pestis antigens, vaccine compositions, and related methods.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies 원문보기

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연합인증

Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

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이 특허를 인용한 특허 (195)

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