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Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/77
출원번호 US-0220307 (1994-03-30)
발명자 / 주소
  • Greenwald Richard B. (Somerset NJ)
출원인 / 주소
  • Enzon, Inc. (Piscataway NJ 02)
인용정보 피인용 횟수 : 143  인용 특허 : 2

초록 ▼

Water-soluble azlactone activated polyalkylene oxides having improved hydrolytic stability and conjugates of the azlactone activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active

대표청구항 ▼

A polyalkylene oxide conjugate comprising: a nucleophile having biological activity; and at least one water-soluble polyalkylene oxide covalently bonded thereto by a hydrolytically stable linkage formed by reacting said nucleophile with an azlactone-activated polyalkylene oxide comprising a structur

이 특허에 인용된 특허 (2)

  1. Domb Abraham J. (Baltimore MD), Biodegradable polymer compositions.
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  2. Coleman Patrick L. (St. Paul) Milbrath Dean S. (St. Paul) Walker Margaret M. (St. Paul MN), Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same.
    상세보기

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