초록

Ionene polymers having biologically-active organic and/or inorganic anions are described. Methods to prepare the ionene polymers, compositions containing them and their methods of use are also described.

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A water-soluble ionene polymer of formula I: [Figure] (I) wherein n is an integer from 4 to 400 corresponding to the degree of polymerization of the polymer; R1, R2, R3 and R4 represent the same or different substituent selected from the group consisting of hydrogen, a C1 to C16 alkyl group, a C1 to

A water-soluble ionene polymer of formula I: [Figure] (I) wherein n is an integer from 4 to 400 corresponding to the degree of polymerization of the polymer; R1, R2, R3 and R4 represent the same or different substituent selected from the group consisting of hydrogen, a C1 to C16 alkyl group, a C1 to C16 alkyl group substituted with one or more hydroxyl groups, a benzyl group, and a benzyl group substituted with one or more C1 to C16 alkyl groups; B represents a divalent C2 to C16 aliphatic hydrocarbon radical which can be substituted by hydroxyl, a divalent C5 to C9 cyclic hydrocarbon radical, a di-(C2 to C6)-alkylene ether, a phenylene or alkyl-substituted phenylene radical, or the divalent group R1R2NBNR3R4 of formula I represents a divalent radical of the structure: R1R2N－(CH2)p－NR5－C(O)－NR6－(CH2)p－NR3R4 where p is an integer from 2 to 6, R1, R2, R3 and R4 are the same as defined above, and R5 and R6 are the same or different and are selected from the group consisting of hydrogen and a C1 to C16 alkyl group, or the divalent radical R1R2NBNR3R4 forms a heterocyclic group selected from 1,2-pyrazolidinyl, 1,3-imidazolindiyl, 1,4-piperazindiyl, aminopyrrolidinyl, or aminopiperidiyl wherein the heterocyclic group may be substituted with one or more groups selected from a C1 to C6 alkyl group, a hydroxyl group, a halide, or a phenyl group; A-is an anion derived from a biologically-active compound having at least one acid functionality with the proviso that said anion is not a halide anion; X-is an anion derived from a mineral or organic acid; and the degree of substitution of the polymer is from about 0.005 to 0.5.