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Method of dehydrating liposomes using protective sugars

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/127
  • B01J-013/02
  • B01J-013/04
출원번호 US-0022819 (1993-02-24)
발명자 / 주소
  • Janoff Andrew S. (Yardley PA) Cullis Pieter R. (Vancouver CAX) Bally Marcel B. (Vancouver CAX) Fountain Michael W. (Griggstown NJ) Ginsberg Richard S. (Monroe NJ) Hope Michael J. (Vancouver CAX) Madd
출원인 / 주소
  • The Liposome Company, Inc. (Princeton NJ 02)
인용정보 피인용 횟수 : 33  인용 특허 : 67

초록

Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. F

대표청구항

A method of dehydrating liposomes which comprises: (i) preparing a preparation of unilamellar liposomes with a protective sugar such that a protective concentration of the sugar is present at the inside and outside surfaces of the liposomes; and (ii) removing water from the preparation; wherein: the

이 특허에 인용된 특허 (67)

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  1. Malinin, Vladimir, Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods of use thereof.
  2. Fenske David B.,CAX ; Cullis Pieter R.,CAX ; Wong Kim,CAX ; Norbert Maurer,CAX ; Leenhouts Johanna M.,CAX ; Maurer Elisabeth,CAX ; Boman Nancy,CAX, Ionophore-mediated liposome loading.
  3. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  4. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  5. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  6. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  7. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  8. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  9. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  10. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  11. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  12. Weers, Jeff, Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof.
  13. Cullis, Pieter R; Madden, Thomas D; Hope, Michael J; Ansell, Steven M; Mui, Barbara L S; Semple, Sean C; Maurer, Norbert, Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof.
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  18. Mundus, Carsten; Welz, Christian; Schramel, Oliver; Haas, Heinrich; Fichert, Thomas; Schulze, Brita; Peymann, Toralf; Michaelis, Uwe; Teifel, Michael; Gruber, Friedrich; Winter, Gerhard, Method of producing a cationic liposomal preparation comprising a lipophilic compound.
  19. Mundus, Carsten; Welz, Christian; Schramel, Oliver; Haas, Heinrich; Fichert, Thomas; Schulze, Brita; Peymann, Toralf; Michaelis, Uwe; Teifel, Michael; Gruber, Friedrich; Winter, Gerhard, Method of producing a cationic liposomal preparation comprising a lipophilic compound.
  20. Sakai,Yasuhiro; Kawashima,Yasuyuki; Inoue,Junya; Ikeuchi,Yoshiro, Method of staining, detection and counting bacteria, and a diluent for bacterial stain.
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  23. Eagle, Gina; Gupta, Renu, Methods for treating pulmonary non-tuberculous mycobacterial infections.
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  26. Gupta, Renu, Methods of treating pulmonary disorders with liposomal amikacin formulations.
  27. Gupta, Renu, Methods of treating pulmonary disorders with liposomal amikacin formulations.
  28. Gupta, Renu, Methods of treating pulmonary disorders with liposomal amikacin formulations.
  29. Dennis R. Morrison ; Benjamin Mosier, Microencapsulated bioactive agents and method of making.
  30. Perkins, Walter; Malinin, Vladimir, Stabilized vancomycin formulations.
  31. Boni, Lawrence T.; Miller, Brian S.; Malinin, Vladimir; Li, Xingong, Sustained release of antiinfectives.
  32. Boni, Lawrence T.; Miller, Brian S.; Malinin, Vladimir; Li, Xingong, Sustained release of antiinfectives.
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