Method for preparing thiol compounds with bacterial b
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12P-011/00
C12P-007/26
C12N-009/88
출원번호
US-0232357
(1994-04-22)
우선권정보
NL-0000240 (1987-01-30)
발명자
/ 주소
Kerkenaar Antonius (Blaricum NLX) Schmedding Diederik J. M. (Driebergen NLX) Berg Jan (Nieuwegein NLX)
출원인 / 주소
Nederlandse Organisatie Voor Toegepast (NLX 03)
인용정보
피인용 횟수 :
4인용 특허 :
3
초록▼
A method for preparing thiol compounds, comprising: (1) reacting cysteine by a non-enzymatical addition reaction with a compound having the formula (R1)(R2)C〓C(R3)-CO-R4 via an -S-bridge to form a cysteine conjugate, wherein the symbols R1, R2, R3 and R4 represent hydrogen or an optionally saturated
A method for preparing thiol compounds, comprising: (1) reacting cysteine by a non-enzymatical addition reaction with a compound having the formula (R1)(R2)C〓C(R3)-CO-R4 via an -S-bridge to form a cysteine conjugate, wherein the symbols R1, R2, R3 and R4 represent hydrogen or an optionally saturated and/or heterogeneous hydrocarbon group or wherein a combination of two groups selected from the group consisting of R1, R3 and R4, together with the carbon atoms to which the groups are bonded, form an optionally saturated and/or heterogeneous hydrocarbon ring system of five or six members; and (2) reacting the cysteine conjugate so obtained in a concentration of >1 mM conjugate with a microbial b
대표청구항▼
A method for preparing thiol compounds, comprising: (1) reacting cysteine by a non-enzymatical addition reaction with a compound having the formula (R1)(R2)C〓C(R3)-CO-R4 via an -S-bridge to form a cysteine conjugate, wherein R1, R2 and R3 are each selected from the group consisting of: hydrogen; an
A method for preparing thiol compounds, comprising: (1) reacting cysteine by a non-enzymatical addition reaction with a compound having the formula (R1)(R2)C〓C(R3)-CO-R4 via an -S-bridge to form a cysteine conjugate, wherein R1, R2 and R3 are each selected from the group consisting of: hydrogen; an alkyl group containing 1-5 carbon atoms; an alkylene group containing 2-6 carbon atoms; a cycloalkyl or cycloalkenyl group containing 5-10 carbon atoms and an aryl group containing 6-10 carbon atoms; and R4 is selected from the group consisting of: hydrogen; an alkyl group containing 1-5 carbon atoms; an alkylene group containing 2-6 carbon atoms; a cycloalkyl or cycloalkenyl group containing 5-10 carbon atoms; an aryl group containing 6-10 carbon atoms; -OH and -OCH3, or wherein a combination of two groups selected from the group consisting of R1, R3 and R4, together with the carbon atoms to which the groups are bonded, form a ring system of five or six members, wherein said ring has 0-3 ethenically unsaturated bonds and wherein said ring has 0-2 heterogeneous atoms selected from the group consisting of N and O, or wherein said compound having the formula (R1)(R2)C〓C(R3)-CO-R4 is a compound having the formula: [Figure] in which the R5 is selected from the group consisting of hydrogen, an alkyl containing 1-24 carbon atoms and an alkaline ion, and R6 is 1-7 monosaccharides and wherein said monosaccharides are selected from the group consisting of glucose, mannose, galactose, arabinose, fucose, xylose, rhamnose, uronic acid, and acetate, pyruvate, amine and sulfate derivatives thereof, and (2) reacting said cysteine conjugate in a concentration of >1 mM conjugate with a cysteine conjugate bEubacterium limosum, Escherichia coli, Fusobacterium varium, Fusobacterium nucleatum, Salmonella typhimurium, Enterobacter cloacae, Bacillus brevis, Pseudomonas taetrolens, Pseudomonas aromatica and Pseudomonas fluorescens to form a thiol compound and recovering said thiol compound.
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이 특허에 인용된 특허 (3)
Rowley Gerald L. (San Jose CA) Leung Danton (Campbell CA) Singh Prithipal (Santa Clara CA), Enzyme-aminoglycoside conjugates.
Roberts, Jeannette C.; Wilmore, Britta H.; Cassidy, Pamela B.; Dominick, Pamela K.; Short, Megan D., Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof.
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