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Mesoscale polynucleotide amplification devices 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • G01N-033/50
  • G01N-021/01
출원번호 US-0338728 (1994-11-14)
발명자 / 주소
  • Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA)
출원인 / 주소
  • The Trustees of the University of Pennsylvania (Philadelphia PA 02)
인용정보 피인용 횟수 : 753  인용 특허 : 17

초록

Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction chamber, having at least one cross-sectional dimension of

대표청구항

A device for amplifying a polynucleotide in a sample by conducting a polynucleotide amplification reaction, the device comprising: a solid substrate fabricated to include at least one polynucleotide amplification reaction chamber, said chamber being permanently sealed with a cover and having one mes

이 특허에 인용된 특허 (17)

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  584. Wilson, Brian D.; Davis, Matthew S.; Erickson, Matthew D.; Johnson, Alan N.; Maurer, Garrick A.; Schmidt, Daniel R.; Wiltsie, Joshua D., Reaction vessel.
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  586. Squirrell, David James, Reagent delivery system.
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  591. Van Atta, Reuel; Dias Lourenco, Francisco Javier, Reagent reservoir system for analytical instruments.
  592. Van Atta, Reuel; Francisco, Dias Lourenco, Reagent reservoir system for analytical instruments.
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  594. Handique, Kalyan; Springer, Theodore, Reagent tube.
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  620. Samuels, Michael; Link, Darren Roy, Sandwich assays in droplets.
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  622. Gubatayao, Thomas Catalino; Handique, Kalyan; Ganesan, Karthik; Drummond, Daniel M., Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection.
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  626. Li, Shifeng; Bustillo, James; Hinz, Wolfgang, Sensor arrays and methods for making same.
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  628. Faham, Malek; Moorhead, Martin; Willis, Thomas, Sequence analysis of complex amplicons.
  629. Parce, J. Wallace; Nikiforov, Theo T.; Mehta, Tammy Burd; Kopf Sill, Anne R.; Chow, Andrea W.; Knapp, Michael R., Sequencing by incorporation.
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  633. Lean, Meng H.; Kole, Ashutosh; Seo, Jeonggi, Serpentine structures for continuous flow particle separations.
  634. Lean, Meng H.; Kole, Ashutosh; Seo, Jeonggi, Serpentine structures for continuous flow particle separations.
  635. Altendorf Eric H. ; Yager Paul, Silicon microchannel optical flow cytometer.
  636. Faham, Malek; Willis, Thomas, Single cell analysis by polymerase cycling assembly.
  637. Lentz, Ammon David; St-Pierre, Richard; Livingston, Dwight; Steel, Adam Bruce, Single piece reagent holder.
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  640. Hall, Jeff G.; Lukowiak, Andrew A.; Peterson, Patrick, Snap-back primers and detectable hairpin structures.
  641. Hall, Jeff G.; Lukowiak, Andrew A.; Peterson, Patrick, Snap-back primers and detectable hairpin structures.
  642. Müller, Martin; Weihs, Andreas; Gunzer, Gerhard; Eberhardt, Michael, Specimen container detection.
  643. Ackley Donald E. ; Sheldon Edward L. ; Krihak Michael K., Stacked, reconfigurable system for electrophoretic transport of charged materials.
  644. Amigo M. Goretty Alonso ; McCormick Randy M., Surface modified electrophoretic chambers.
  645. Steven A. Henck, Surface treatments for DNA processing devices.
  646. Church George M. ; Bulyk Martha L., Surface-bound, bimolecular, double-stranded DNA arrays.
  647. Church, George M.; Bulyk, Martha L., Surface-bound, double-stranded DNA protein arrays.
  648. Bridgham, John; Corcoran, Kevin; Golda, George; Brenner, Sydney; Pallas, Michael C., System and apparatus for sequential processing of analytes.
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  652. Gao, Chuan; Yu, Tianyue, System and method for bubble removal.
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  654. Li, Shifeng; Owens, Jordan, System and method for forming microwells.
  655. Breidford, Wayne L.; Lancaster, Christy A.; Hayenga, Jon W.; Bardell, Ronald L.; Tonn, Jeffrey F.; Weigl, Bernhard H., System and method for heating, cooling and heat cycling on microfluidic device.
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  657. Gao, Chuan; Yamamoto, Melvin, System and method for making lab card by embossing.
  658. Shirazi, Mohsen, System and method for processing large number of biological microarrays.
  659. Johns, Charles W., System and method for processing samples.
  660. Seul,Michael; Chau,Chiu Wo, System and method for programmable illumination pattern generation.
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  663. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Eric; Jones, Mark; Overbeck, James T.; DeWeerd, Herman; Stura, David A.; Bukys, Albert K.; Woolaver, Tim J.; Regan, Thomas P.; Bradbury, David; McKenzie, Eric E.; DiPaolo, Roger; Miles, Christopher; Katz, Joel M.; Ksenia, Oleinik-Ovod, System and method for scanning of probe arrays.
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  669. Makarewicz, Anthony J.; Hiddessen, Amy L., System for detection of spaced droplets.
  670. Makarewicz, Jr., Anthony J.; Hiddessen, Amy L., System for detection of spaced droplets.
  671. Hindson, Benjamin Joseph; Ness, Kevin Dean; Colston, Jr., Billy Wayne; Milanovich, Fred Paul; Masquelier, Donald Arthur; Makarewicz, Jr., Anthony Joseph, System for droplet-based assays using an array of emulsions.
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  674. Hiddessen, Amy L.; Masquelier, Donald A.; Ness, Kevin D.; Hindson, Benjamin J.; Makarewicz, Jr., Anthony J.; Chia, Erin R., System for forming emulsions.
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  677. Hiddessen, Amy L.; Ness, Kevin D.; Hindson, Benjamin J.; Masquelier, Donald A., System for generating droplets—instruments and cassette.
  678. Hindson, Benjamin J., System for hot-start amplification via a multiple emulsion.
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  681. Patno, Tim; Westberg, Tom; Weber, Mark; Rush, Benjamin; Khoury, Christopher; Morrow, David; Ruszel, Janusz; Kronshage, Christian; Cork, William, System using self-contained processing module for detecting nucleic acids.
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  683. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Eric; Jones, Mark; Overbeck, James; Deweerd, Herman; Stura, David A.; Bukys, Albert; Woolaver, Tim; Regan, Thomas P.; Bradbury, David; McKenzie, Eric Earl; DiPaolo, Roger; Miles, Christopher; Katz, Joel M.; Oleink-Ovod, Ksenia, System, method, and product for scanning of biological materials.
  684. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Eric; Jones, Mark; Overbeck, James; Deweerd, Herman; Stura, David A.; Bukys, Albert; Woolaver, Tim; Regan, Thomas P.; Bradbury, David; McKenzie, Eric Earl; DiPaolo, Roger; Miles, Christopher; Katz, Joel M.; Oleink-Ovod, Ksenia, System, method, and product for scanning of biological materials.
  685. Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Erik; Jones, Mark; Overbeck, James; Deweerd, Herman; Stura, David A.; Bukys, Albert; Woolaver, Tim; Regan, Thomas P.; Bradbury, David; McKenzie, Eric Earl; DiPaolo, Roger; Miles, Christopher; Katz, Joel; Oleink-Ovod, Ksenia, System, method, and product for scanning of biological materials.
  686. Kaiser,Michael D., System, method, and product for scanning of biological materials employing dual analog integrators.
  687. Ludowise, Peter D.; Whitman, David A.; Armantrout, Kyle C.; Exner, Maurice; Jacky, Lucien A. E.; Tabb, Michelle, Systems and methods for detecting the presence of a selected volume of material in a sample processing device.
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  689. Owen, Gregory H.; Dale, Gregory A.; Hasson, Kenton C.; Zeng, Shulin; Warfield, Dwayne W., Systems and methods for real-time PCR.
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  695. Ludowise, Peter D.; Smith, Jeffrey D., Systems and methods for valving on a sample processing device.
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  703. James P. Brody ; Thor D. Osborn, Tangential flow planar microfabricated fluid filter.
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  713. McBride, Lincoln; Facer, Geoffrey; Unger, Marc; Lucero, Michael; Nassef, Hany Ramez, Thermal reaction device and method for using the same.
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  722. Bächi, Daniel, Thermo-optical analysis system for biological reactions.
  723. Lee, John K., Thermoelectric control for field emission display.
  724. Lee,John K., Thermoelectric control for field emission display.
  725. Hubbell, Earl, Time-warped background signal for sequencing-by-synthesis operations.
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  727. Chow,Calvin Y. H., Total analyte quantitation.
  728. Seul, Michael; Banerjee, Sukanta; Podual, Kairali; Hong, Ye, Un-supported polymeric film with embedded microbeads.
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  735. Farinas, Javier Anibal; Wada, H. Garrett, Use of Nernstein voltage sensitive dyes in measuring transmembrane voltage.
  736. Maier Elmar,DEX ; Ivanov Igor,DEX, Use of an osmolyte for reducing or abolishing no-covalent interactions of biological molecules to inert surfaces.
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  740. Kayyem, Jon Faiz, Use of microfluidic systems in the electrochemical detection of target analytes.
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  742. Kayyem, Jon Faiz, Use of microfluidic systems in the electrochemical detection of target analytes.
  743. Kayyem, Jon Faiz, Use of microfluidic systems in the electrochemical detection of target analytes.
  744. Farinas, Javier Anibal; Wada, H. Garrett, Use of nernstein voltage sensitive dyes in measuring transmembrane voltage.
  745. Farinas, Javier Anibal; Wada, H. Garrett, Use of nernstein voltage sensitive dyes in measuring transmembrane voltage.
  746. Oldham, Mark F.; Fawcett, Adrian, Vacuum assist for a microplate.
  747. Oldham, Mark F.; Fawcett, Adrian, Vacuum assist for a microplate.
  748. Buckland, Justin Rorke; McCrone, James Edward; Hatfield, Stuart Andrew, Valve.
  749. Brody James P., Valveless liquid microswitch.
  750. Griffiths, Andrew David; Weitz, David; Link, Darren; Ahn, Keunho; Bibette, Jerome, Vitro evolution in microfluidic systems.
  751. Murphy, Matthew B.; Dubrow, Robert S., Western blot by incorporating an affinity purification zone.
  752. Murphy, Matthew B.; Dubrow, Robert S., Western blot by incorporating an affinity purification zone.
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