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Texaphyrin-oligonucleotide conjugates

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/715
  • C07D-487/22
출원번호 US-0458909 (1995-06-02)
발명자 / 주소
  • Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA) Kral Vladimir A. (Austin TX) Magda Darren (Cupertino CA)
출원인 / 주소
  • Pharmacyclics, Inc. (Sunnyvale CA 02) Board of Trustees, Univ. of TX Sys. (Austin TX 02)
인용정보 피인용 횟수 : 173  인용 특허 : 29

초록

Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl

대표청구항

A texaphyrin having the structure: [Figure] wherein, M is H, a divalent metal cation or a trivalent metal cation; each of R1, R2, R3, R4, R7, and R8 is independently hydrogen, hydroxyl, alkyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, oxyaminoalkyl, carboxy, carboxyalkyl, carboxyamidealky

이 특허에 인용된 특허 (29)

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  8. Sessler Jonathan L. (Austin TX) Toshiaki Murai (Gifu TX JPX) Hemmi Gregory W. (Austin TX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles for singlet oxygen production.
  9. Lauffer Randall B. (Boston MA) Brady Thomas J. (Winchester MA), Hepatobiliary NMR contrast agents.
  10. Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA) Krl Vladimir (Na Kozaaoa CSX), Hydroxylated texaphyrins.
  11. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Metal complexes of water soluble texaphyrins.
  12. Judy Millard M. (Dallas TX) Matthews James L. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Franklin (Dallas TX), Method for eradicating infectious biological contaminants in body tissues.
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  20. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles.
  21. Wentland Mark P. (Colonie NY), Quinolonecarboxamide compounds, their preparation and use as antivirals..
  22. Sessler Jonathan L. (Austin TX) Cyr Michael J. (Austin TX), Sapphyrins, derivatives and syntheses.
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  24. Bommer Jerry C. (Ogden UT) Burnham Bruce F. (Logan UT), Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents.
  25. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Tumor imaging and treatment by water soluble texaphyrin metal complexes.
  26. Lauffer Randall B. (Boston MA), Vivo enhancement of NMR relaxivity.
  27. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Water soluble texaphyrin metal complexes for singlet oxygen production.
  28. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Water soluble texaphyrin metal complexes for viral deactivation.
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