Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA) Kral Vladimir A. (Austin TX) Magda Darren (Cupertino CA)
출원인 / 주소
Pharmacyclics, Inc. (Sunnyvale CA 02) Board of Trustees, Univ. of TX Sys. (Austin TX 02)
인용정보
피인용 횟수 :
173인용 특허 :
29
초록▼
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
대표청구항▼
A texaphyrin having the structure: [Figure] wherein, M is H, a divalent metal cation or a trivalent metal cation; each of R1, R2, R3, R4, R7, and R8 is independently hydrogen, hydroxyl, alkyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, oxyaminoalkyl, carboxy, carboxyalkyl, carboxyamidealky
A texaphyrin having the structure: [Figure] wherein, M is H, a divalent metal cation or a trivalent metal cation; each of R1, R2, R3, R4, R7, and R8 is independently hydrogen, hydroxyl, alkyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, oxyaminoalkyl, carboxy, carboxyalkyl, carboxyamidealkyl, an oligonucleotide or a couple to an oligonucleotide, where at least one of R1, R2, R3, R4, R7 and R8 is an oligonucleotide or a couple to an oligonucleotide; and N is zero, 1 or 2.
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이 특허에 인용된 특허 (29)
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