Texaphyrin macrocycles and metal complexes thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-049/00
C07D-255/02
출원번호
US-0207845
(1994-03-08)
발명자
/ 주소
Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX)
출원인 / 주소
Board of Regents, The University of Texas System (Austin TX 02)
인용정보
피인용 횟수 :
14인용 특허 :
17
초록▼
The present invention involves a novel tripyrrole dimethine-derived “expanded porphyrin”(texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes
The present invention involves a novel tripyrrole dimethine-derived “expanded porphyrin”(texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physiologically important region (i.e. 690-880 nm). These complexes also form long-lived triplet states in high yield and act as efficient photosensitizers for the formation of singlet oxygen. These properties, coupled with their high chemical stability and appreciable solubility in polar media such as water, add to their usefulness.
대표청구항▼
A compound having the structure [Figure] wherein the substituents R1, R2 and R3 are separately and independently selected from the group consisting of H, alkyl, amino, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, ester, amide, polyether, sulfonato, nitro, halide other than iodide, substitute
A compound having the structure [Figure] wherein the substituents R1, R2 and R3 are separately and independently selected from the group consisting of H, alkyl, amino, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, ester, amide, polyether, sulfonato, nitro, halide other than iodide, substituted alkyl, substituted ester, substituted ethers, and substituted amide; R4 and R5 are separately and independently selected from the group consisting of H, alkyl, amino, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, ester, amide, polyether, sulfonato, nitro, halide other than iodide, substituted alkyl, substituted ester, substituted ethers and substituted amide or together form an alkenylene bridge of the formula -C(R6)〓C(R7)-CH〓CH-; where R6 and R7 are separately and independently selected from the group consisting of H, alkyl, amino, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, ester, amide, polyether, sulfonato, nitro, halide other than iodide, substituted alkyl, substituted ester, substituted ethers and substituted amide; M is H, a di- or trivalent metal cation; and n is between -5 and +5.
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이 특허에 인용된 특허 (17)
Sieber Fritz (Brookfield WI), Antiviral method, agents and apparatus.
Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Aromatic pentadentate expanded porphyrins in magnetic resonance imaging.
Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Nagara JPX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles.
Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumors.
Sessler Jonathan L. (Austin TX) Toshiaki Murai (Gifu TX JPX) Hemmi Gregory W. (Austin TX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles for singlet oxygen production.
Judy Millard M. (Dallas TX) Matthews James L. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Franklin (Dallas TX), Method for eradicating infectious biological contaminants in body tissues.
Judy Millard M. (Dallas TX) Matthews James L. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Franklin (Dallas TX), Method for eradicating infectious biological contaminants in body tissues.
Matthews J. Lester (Dallas TX) Judy Millard M. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Frank (Dallas TX) Sessler Jonathan L. (Austin TX) Harriman Anthony (Austin TX) Maiya Bhaskar , Photodynamic viral deactivation with sapphyrins.
Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles.
Sessler Jonathan L. ; Harriman Anthony,FRX ; Miller Richard A. ; Magda Darren ; Mody Tarak D. ; Hemmi Gregory W., Radiation sensitization using texaphyrins.
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