초록 ▼

Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18

Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18 and/or 21 contribute electrons to the aromatic p

대표청구항 ▼

A method of radiation therapy for a host harboring atheroma or neoplastic tissue, the method comprising: administering to the host a texaphyrin, the texaphyrin having radiosensitization properties; and administering ionizing radiation to the host in proximity to the atheroma or neoplastic tissue; wh

A method of radiation therapy for a host harboring atheroma or neoplastic tissue, the method comprising: administering to the host a texaphyrin, the texaphyrin having radiosensitization properties; and administering ionizing radiation to the host in proximity to the atheroma or neoplastic tissue; wherein the texaphyrin has the structure: [Figure] wherein M is H, a divalent metal cation, or a trivalent metal cation; R1-R4, R7 and R8 are independently hydrogen, halide, hydroxyl, alkyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, saccharide, carboxy, carboxyalkyl, carboxyamidealkyl, a site-directing molecule, a catalytic group, or a couple to a site-directing molecule or to a catalytic group; R6 and R9 are independently selected from the groups of R1-R4, R7 and R8, with the proviso that the halide is other than iodide and the haloalkyl is other than iodoalkyl; R5and R10-R12 are independently hydrogen, alkyl, aryl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, carboxyalkyl, carboxyamidealkyl or a couple to a saccharide, to a site-directing molecule or to a catalytic group; at least one of R5, R6, R9, R10, R11 and R12 is other than hydrogen; and Z is an integer less than or equal to 5.