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Oligonucleotide N3→P5′phosphoramidates: triplex DNA formation 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-019/34
  • C12Q-001/68
  • C07H-021/04
출원번호 US-0478470 (1995-06-06)
발명자 / 주소
  • Gryaznov Sergei M. (San Mateo CA) Schultz Ronald G. (Fremont CA) Chen Jer-kang (Palo Alto CA)
출원인 / 주소
  • Lynx Therapeutics, Inc. (Hayward CA 02)
인용정보 피인용 횟수 : 135  인용 특허 : 5

초록 ▼

Modified oligonucleotides 3′-NHP(O)(O-)O-5′phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more st

대표청구항 ▼

A method of generating a triplex DNA molecule, comprising: contacting a target duplex DNA with an oligodeoxyribonucleotide comprising a sequence of nucleoside subunits that hybridize with said target duplex DNA, wherein: (i) 100% of the inter-subunit linkages of said oligodeoxyribonucleotide are N3′

이 특허에 인용된 특허 (5)

  1. Cho-Chung Yoon S. (7017 Kenhill Rd. Bethesda MD 20817), Antisense oligonucleotides of human regulatory subunit RIaof cAMP-dependent prot.
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  2. Froehler Brian C. (Belmont CA), Exonuclease-resistant oligonucleotides.
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  3. Hogan Michael E. (The Woodlands TX) Kessler Donald J. (The Woodlands TX), Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming.
    상세보기
  4. Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
    상세보기
  5. Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
    상세보기

이 특허를 인용한 특허 (135)

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AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

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