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Biological reagent spheres 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/00
  • C12Q-001/34
  • C12Q-001/37
  • C12P-021/06
출원번호 US-0420933 (1995-04-12)
발명자 / 주소
  • Treml Suzanne B. (Whitefish Bay WI) Dall Cristine J. (Shorewood WI) Draveling Connie A. (New Berlin WI) Jolly James F. (Glendale WI) Ramanujam Rama P. (Brookfield WI)
출원인 / 주소
  • Pharmacia Biotech, Inc. (Milwaukee WI 02)
인용정보 피인용 횟수 : 38  인용 특허 : 23

초록 ▼

A reagent sphere is disclosed comprising at least one biological reagent and a glass-forming filler material in a concentration sufficient to facilitate formation of a glassy, porous composition, wherein the reagent semi-sphere is water soluble and has a Tg sufficient for room temperature stability.

대표청구항 ▼

A reagent sphere comprising: at least one biological reagent; and a glass-forming filler material in a concentration sufficient to facilitate formation of a glassy, porous composition wherein the glass-forming filler comprises a mixture of a high molecular weight synthetic carbohydrate polymer and a

이 특허에 인용된 특허 (23)

  1. Cimiluca Paul A. (Succasunna NJ), Candy base and liquid center hard candy made therefrom.
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  2. Roy Suva B. (Bear DE), Co-spray technique.
    상세보기
  3. Carpenter John F. (Davis CA) Hand Steven C. (Lafayette LA) Crowe John H. (Davis CA) Crowe Lois M. (Davis CA), Cryogenic protectant for proteins.
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  4. Carpenter John F. (David CA) Hand Steven C. (Louisville CO) Crowe Lois M. (Davis CA) Crowe John H. (Davis CA), Cryogenic protection of phosphofructokinase using amino acids and zinc ions.
    상세보기
  5. Fahy, Gregory M., Cryopreservation of biological materials in a non-frozen or vitreous state.
    상세보기
  6. Kuypers Leonardus P. C. (Tc Teeffelen NLX) Wolters Gerrit (El Oss NLX), Device for the carrying out of an immunochemical determination.
    상세보기
  7. Davis Robert B. (Nyack NY) DeVack Donald L. (Norwalk CT), Droplet freezing method and apparatus.
    상세보기
  8. Gibson Timothy D. (Leeds OH GB2) Woodward John R. (Xenia OH), Enzyme stabilisation.
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  9. Jolly James F. (Glendale WI) Chirikjian Jack G. (Potomac MD) Huang Caecilia J. (New Berlin WI), Glassified restriction enzymes.
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  10. Corsello Vincent (Cedar Knolls NJ) Glass Michael (Fair Lawn NJ) Ross Norton (Randolph NJ) Hohclick Joseph (Hopatcong NJ) Bilka Kenneth P. (Floral Park NY), Method for increasing salivation for xerostomia patients.
    상세보기
  11. Briggs Anglis R. (Newark DE) Maxwell Thomas J. (Philadelphia PA), Method of preparation of lyophilized biological products.
    상세보기
  12. McGeehan John K. (Woodbury NJ), Method of preparing particles suitable for tabletting into diagnostic reagents.
    상세보기
  13. Wettlaufer Scott H. (Newfield NY) Leopold Aldo C. (Ithaca NY), Method of protecting biological materials from destructive reactions in the dry state.
    상세보기
  14. McGinity James W. (Austin TX) Iwata Motokazu (Osaka JPX), Preparation and uses of multi-phase microspheres.
    상세보기
  15. Temple George A. (Toronto CAX) Kirkwood Donald W. (Oakville CAX) Milankov Bosko (Mississauga CAX), Process for freezing or chilling.
    상세보기
  16. Devos Francis (Morbecque-Merville FRX) Bussiere Guy (La Gorgue FRX) Huchette Michel (Merville FRX), Process for hard coating with sorbitol and products obtained thereby.
    상세보기
  17. Knitsch Karl-Wolfgang (Starnberg DE1) Hagen Alexander (Tutzing DE1) Munz Eberhard (Polling DE1) Determann Helmut (Starnberg DE1), Production of porous tablets.
    상세보기
  18. Roser Bruce J. (Balsham GB3), Protection of proteins and the like.
    상세보기
  19. Silva Jose N. (Astoria NY) Yang Robert K. (Randolph NJ) Zamudio-Tena Jose F. (Morristown NJ), Sorbitol coated comestible and method of preparation.
    상세보기
  20. Franks Felix (Cambridge GB2) Hatley Ross H. M. (Hardwick GB2), Storage of materials.
    상세보기
  21. Bollin ; Jr. Ernest (Bear DE) Fletcher Mark G. (Hartlend WI), Trehalose as stabilizer and tableting excipient.
    상세보기
  22. Onouchi Takashi (Tokyo JPX) Sugai Hironori (Yokohama JPX) Sekiguchi Kazuo (Nagareyama JPX) Hosoda Yoshikazu (Fujisawa JPX) Yoshida Eiichi (Tokyo JPX), Water-soluble microcapsules.
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  23. Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH) Maffia Gennaro J. (Leba, Weighted collagen microsponge for immobilizing bioactive materials.
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이 특허를 인용한 특허 (38)

  1. Horton, Jeffrey Kenneth; Tatnell, Peter James; Ogden, Samantha Jane; Smith, Michael John; Goren, Leonard J.; Pepe, Steven; Langar, Samit; Pizzi, Vincent Francis; Robinson, Craig, Biometric device and means for electronic storage and retrieval of biometric data.
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  2. Eddy, Brad; Qiao, Zhisong; O'Connell, Kevin, Bovine virus vaccines that are liquid stable.
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  3. Eddy, Brad; Qiao, Zhisong; O'Connell, Kevin, Bovine virus vaccines that are liquid stable.
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  4. Battrell, C. Frederick; Hoekstra, Denise Maxine; Haab, Joan; Williford, John R.; Gates, Sabrina N.; Leber, Elizabeth R.; Sprague, Isaac, Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices.
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  5. Battrell, C. Frederick; Hoekstra, Denise Maxine; Haab, Joan; Williford, John R.; Gunderson, Sabrina N.; Leber, Elizabeth R.; Sprague, Isaac, Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices.
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  6. Whitney, Scott E.; Wilkinson, Steven; Muller, Rolf, Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures.
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  7. Whitney, Scott E.; Ghirmai, Senait; Muller, Rolf, Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures.
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  8. Whitney, Scott E.; Wilkinson, Steven; Muller, Rolf, Compositions for stabilizing DNA, RNA, and proteins in blood and other biological samples during shipping and storage at ambient temperatures.
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  9. Weber, Wolfgang, Detection of an analyte in aqueous media.
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  10. Lofquist, Alan K.; Battrell, C. Frederick; Bouzek, Heather K., Device for preparation and analysis of nucleic acids.
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  11. Muller Uwe Richard, Diagnostic methods and probes.
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  12. Metzler, Thomas; Haslinger, Tobias; Peceny, Annette; Sobek, Harald, Dry composition of reaction compounds with stabilized polymerase.
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  13. Metzler, Thomas; Haslinger, Tobias; Peceny, Annette; Sobek, Harald, Dry composition of reaction compounds with stabilized polymerase.
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  14. Metzler, Thomas; Haslinger, Tobias; Peceny, Annette; Sobek, Harald, Dry composition of reaction compounds with stabilized polymerase.
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  15. Qiao, Zhisong; O'Connell, Kevin, Dry formulations of vaccines that are room temperature stable.
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  16. Li, Bing; Moore, David Roger; Alberts, William Christopher; Nelson, John Richard, Electrospun fibers for protein stabilization and storage.
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  17. Whitney, Scott E.; De Los Rios, Stephanie; Ghirmai, Senait; Muller, Rolf; Liberal, Vasco; Wilkinson, Steven P., Formulations and methods for stabilizing PCR reagents.
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  18. Bronshtein, Victor; Bracken, Kevin R.; Livers, Ronnie K.; Williams, David R., Industrial scale barrier technology for preservation of sensitive biological materials.
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  19. Bronshtein Victor ; Bracken Kevin R. ; Livers Ronnie K. ; Williams David R., Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures.
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  20. Muller-Cohn, Judy; Muller, Rolf, Integration of sample storage and sample management for life science.
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  21. Muller-Cohn, Judy; Muller, Rolf; Herrnstadt, Corinna, Integration of sample storage and sample management for life science.
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  22. Buchanan, Sandhya; O'Connell, Kevin, Liquid stable bovine virus vaccines.
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  23. Qiao, Zhisong; O'Connell, Kevin, Liquid stable virus vaccines.
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  24. Qiao, Zhisong; O'Connell, Kevin, Liquid stable virus vaccines.
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  25. Bouzek, Heather K., Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions.
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  26. Bronshtein, Victor, Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals.
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  27. LaCroix Karol K. ; Shaffer Christy L. ; Jacobus Karla M. ; Rideout Janet L. ; Drutz David J. ; Evans Richard C. ; Pendergast William, Pharmaceutical compositions of uridine triphosphate.
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  28. Pluester, Wilhelm; Ziegmann, Christian, Porous media.
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  29. Qiao, Zhisong; Cook, Stephanie; O'Connell, Kevin; Tarpey, Ian, Poultry virus vaccines that are liquid stable.
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  30. Ponaka, Reddy; Farchaus, Joseph W.; Pierce, Michael D., Preparation of glassified biological reagents.
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  31. Yager, Paul; Lutz, Barry R.; Fu, Elain S.; Fridley, Gina; Le, Huy Quang; Kauffman, Peter C., Reagent patterning in capillarity-based analyzers and associated systems and methods.
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  32. Harttig Herbert,DEX, Reagent preparation containing magnetic particles in tablet form.
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  33. Harttig, Herbert, Reagent preparation containing magnetic particles in tablet form.
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  34. Battrell, C. Frederick; Hoekstra, Denise Maxine; Haab, Joan; Williford, John R., Rehydratable matrices for dry storage of TAQ polymerase in a microfluidic device.
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  35. Muller, Rolf; Desharnais, Joel; Wilkinson, Steven P.; Arendt, Victoria; Diaz, Paul, Stabilization of thrombocytes at ambient temperatures.
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  36. Kovacs, Ernest William; Kvam, Erik Leeming; Li, Bing; Mondello, Frank John, Substrates and methods for collection, stabilization and elution of biomolecules.
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  37. O'Connell, Kevin; Qiao, Zhisong; Eddy, Brad; Strait, Erin, Swine virus vaccines that are liquid stable.
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  38. Pellegrini Frank C., Transdermal drug delivery system.
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