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A shipper for safely transporting materials, particularly materials which must be precooled and maintained within a predetermined temperature for the time period while in transport, is provided. The shipper has a vessel for receiving and containing the sample material. The vessel has a contiguous wa

A shipper for safely transporting materials, particularly materials which must be precooled and maintained within a predetermined temperature for the time period while in transport, is provided. The shipper has a vessel for receiving and containing the sample material. The vessel has a contiguous wall defining a vessel cavity and a port for receiving the precooled material. A lid sealably engages with the port, the lid having an inert surface adjacent to the vessel cavity. A precooled refrigerant removably jackets the vessel to maintain the precooled material within a predetermined temperature range for a given period of time. A primary safeguard assembly for enclosing the jacketed vessel comprises a receptacle having a contiguous wall defining an opening and a receptacle cavity for receiving the refrigerant-jacketed vessel. A cover seals the opening of the receptacle and a sorbent is disposed between the vessel and the receptacle wall. A secondary safeguard assembly encloses the primary safeguard assembly. The secondary safeguard assembly is comprised of an outer structual member, a liquid impermeable liner adjacent to an inner surface of the structural member, and a layer of thermal insulation disposed between the liner and the primary safeguard assembly.

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A method for shipping materials which must be precooled and maintained within a predetermined temperature range for a given period of time comprising: (1) placing precooled material within a precleaned vessel having a contiguous wall defining a vessel cavity and a port for receiving precooled materi

A method for shipping materials which must be precooled and maintained within a predetermined temperature range for a given period of time comprising: (1) placing precooled material within a precleaned vessel having a contiguous wall defining a vessel cavity and a port for receiving precooled material; (2) sealably engaging the port with a precleaned lid having an inert liner adjacent to the vessel cavity; (3) jacketing a precooled refrigerant around the vessel so that the refrigerant maintains the precooled material within a predetermined temperature range for a given period of time; (4) placing the refrigerant-jacketed vessel and the lid within a primary safeguard assembly comprising a receptacle having a contiguous wall defining an opening and a receptacle cavity for receiving the refrigerant-jacketed vessel and lid in sealing engagement therewith through the opening; (5) placing a sorbent between the vessel and the receptacle wall; (6) sealably engaging the opening of the receptacle with a cover; (7) placing the primary safeguard containing the refrigerant jacketed vessel and the lid within a secondary safeguard assembly comprising an outer structual member, a liquid impermeable liner adjacent to an inner surface of the structural member, and a layer of thermal insulation disposed between the liner and the primary safeguard assembly, the thermal insulation having an indentation for receiving the primary safeguard assembly; (8) transporting the assembled secondary safeguard containing the assembled primary safeguard to a remote location; (9) opening the secondary safeguard assembly and removing the vessel from the primary safeguard assembly; and (10) opening the vessel.