Polymeric device for controlled drug delivery to the CNS
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61K-009/00
출원번호
US-0180117
(1994-01-12)
발명자
/ 주소
Sabel Bernhard A. (Egmating DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Baltimore MD) During Matthew J. (Westport CT)
출원인 / 주소
Massachusetts Institute of Technology (Cambridge MA 02)
인용정보
피인용 횟수 :
29인용 특허 :
23
초록▼
Disclosed is a polymeric drug delivery system for delivery of any substance to the central nervous system. The delivery system is preferably implanted in the central nervous system for delivery of the drug directly to the central nervous system. These implantable devices can be used, for example, to
Disclosed is a polymeric drug delivery system for delivery of any substance to the central nervous system. The delivery system is preferably implanted in the central nervous system for delivery of the drug directly to the central nervous system. These implantable devices can be used, for example, to achieve continuous delivery of dopamine, which cannot pass the blood brain barrier, directly into the brain for an extended time period. The implantable devices display controlled, “zero-order”release kinetics, a life time of a minimum of several weeks or months even when the devices contain water soluble, low molecular weight compounds, biocompatibility, and relative non-invasiveness. The polymeric devices are applicable in the treatment of a variety of central nervous system disorders including Parkinson\s disease, Alzheimer\s dementia, Huntington\s disease, epilepsy, trauma, stroke, depression and other types of neurological and psychiatric illnesses.
대표청구항▼
A method for treating disorders characterized by insufficient function of the central nervous system comprising: selecting a compound for treating the disorder by replacing or supplementing a normal function in the central nervous system selected from the group consisting of L-dopa, dopamine, carbid
A method for treating disorders characterized by insufficient function of the central nervous system comprising: selecting a compound for treating the disorder by replacing or supplementing a normal function in the central nervous system selected from the group consisting of L-dopa, dopamine, carbidopa, choline, acetylcholine, cholinergic neuronotrophic agents, gangliosides, nerve growth enhancing agents, antipsychotic agents, antidepressants, excitatory amino acid antagonists and agonists, antiepileptic medications, enzymes, beta-interferon and combinations thereof; encapsulating said compound within said polymer to form a polymeric device, the device formed of a biocompatible polymer that is plastically deformable selected from the group consisting of ethylene vinyl acetate, polyurethanes, polystyrenes, polyamide, polyacrylamide, and combinations thereof having a non-porous polymer coating thereon with one or more openings, with limited water sorptivity and slight permeability to the passage of small, aqueous-soluble molecules, wherein said compound is linearly released from said polymeric device over a sustained period of time of at least 65 days at a predetermined level and rate when implanted in a patient at a specific site within the central nervous system where the compound is released directly into the central nervous system and the device remains essentially intact throughout the release period.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (23)
Sidman Kenneth R. (Wayland MA), Biodegradable, implantable drug delivery device, and process for preparing and using the same.
Sabel Bernhard A. (Munich MA DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Somerville MA), Controlled drug delivery system for treatment of neural disorders.
Dempski Robert E. (Dresher PA) Scholtz Edward C. (King of Prussia PA) Nibbelink Donald W. (Lansdale PA) Reines Scott A. (New Hope PA), Controlled release combination of carbidopa/levodopa.
Dempski Robert E. (Dresher PA) Scholtz Edward C. (King of Prussia PA) Nibbelink Donald W. (Lansdale PA) Reines Scott A. (New Hope PA), Controlled release combination of carbidopa/levodopa.
Sabel Bernhard A. (Kreuzberg 6 8011 Egmating MA DEX) Freese Andrew (115 Whitcomb Ave. Jamaica Plain MA 02130), Extended drug delivery of small, water-soluble molecules.
Folkman Judah (Brookline MA) Langer ; Jr. Robert S. (Somerville MA) Hsieh Dean S. T. (Cambridge MA), Magnetically modulated polymeric drug release system.
Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
Appelgren Curt H. (V Frlunda SEX) Bogentoft Conny B. (Kallered SEX) Sjgren John A. (Mlnlycke SEX), Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating.
Folkman Moses J. (18 Chathman Cir. Brookline MA 02146) Langer ; Jr. Robert S. (1200 Commonwealth ; Apt. 2 Allston MA 02134), Systems for the controlled release of macromolecules.
Siegel, Steven J.; Winey, Karen I.; Gur, Raquel E.; Lenox, Robert H., Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use.
Siegel, Steven J.; Winey, Karen I.; Gur, Raquel E.; Lenox, Robert H., Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use.
Hulvershorn, Justin; Fowler, Brad; Gliner, Bradford Evan; Sloan, Leif R.; Kopell, Brian; Soltysik, David Alan, Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.