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Polymeric device for controlled drug delivery to the CNS

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-002/00
  • A61K-009/00
출원번호 US-0180117 (1994-01-12)
발명자 / 주소
  • Sabel Bernhard A. (Egmating DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Baltimore MD) During Matthew J. (Westport CT)
출원인 / 주소
  • Massachusetts Institute of Technology (Cambridge MA 02)
인용정보 피인용 횟수 : 29  인용 특허 : 23

초록

Disclosed is a polymeric drug delivery system for delivery of any substance to the central nervous system. The delivery system is preferably implanted in the central nervous system for delivery of the drug directly to the central nervous system. These implantable devices can be used, for example, to

대표청구항

A method for treating disorders characterized by insufficient function of the central nervous system comprising: selecting a compound for treating the disorder by replacing or supplementing a normal function in the central nervous system selected from the group consisting of L-dopa, dopamine, carbid

이 특허에 인용된 특허 (23)

  1. Sidman Kenneth R. (Wayland MA), Biodegradable, implantable drug delivery device, and process for preparing and using the same.
  2. Sabel Bernhard A. (Munich MA DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Somerville MA), Controlled drug delivery system for treatment of neural disorders.
  3. Bloch Rene (Savion IL) Kedem Ora (Rehovoth IL) Lobel Ester (Hulon IL), Controlled drug releasing preparations.
  4. Dempski Robert E. (Dresher PA) Scholtz Edward C. (King of Prussia PA) Nibbelink Donald W. (Lansdale PA) Reines Scott A. (New Hope PA), Controlled release combination of carbidopa/levodopa.
  5. Dempski Robert E. (Dresher PA) Scholtz Edward C. (King of Prussia PA) Nibbelink Donald W. (Lansdale PA) Reines Scott A. (New Hope PA), Controlled release combination of carbidopa/levodopa.
  6. Sparks Randall T. (Gainesville GA) Geoghegan Edward J. (Athlone IEX), Controlled release powder and process for its preparation.
  7. Theeuwes Felix (Los Altos CA), Device with integrated operations for controlling release of agent.
  8. Schmitt Edward E. (Palo Alto CA), Drug delivery devices comprising erodible polymer and erosion rate modifier.
  9. Higuchi ; Takeru ; Hussain ; Anwar, Drug-delivery device comprising certain polymeric materials for controlled release of drug.
  10. Sabel Bernhard A. (Kreuzberg 6 8011 Egmating MA DEX) Freese Andrew (115 Whitcomb Ave. Jamaica Plain MA 02130), Extended drug delivery of small, water-soluble molecules.
  11. Folkman Judah (Brookline MA) Langer ; Jr. Robert S. (Somerville MA) Hsieh Dean S. T. (Cambridge MA), Magnetically modulated polymeric drug release system.
  12. Anderson Mark E. (21 Southampton Ct. Newport Beach CA 92660), Method for administering interleukin-2.
  13. Sadek Safik E. (Wayland MA), Methods of improving control of release rates and products useful in same.
  14. Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
  15. Aebischer Patrick (Providence RI) Winn Shelley R. (Providence RI), Neurological therapy devices.
  16. Aebischer Patrick (Providence RI) Winn Shelley R. (Providence RI), Neurological therapy system.
  17. Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
  18. Michaels Alan S. (San Francisco CA) Guillod Mark S. (Kaneohe HI), Osmotic bursting drug delivery device.
  19. Appelgren Curt H. (V Frlunda SEX) Bogentoft Conny B. (Kallered SEX) Sjgren John A. (Mlnlycke SEX), Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating.
  20. Sudmann Einar (Os CA NOX) Bonsen Pieter (Los Altos CA) Lee Eun S. (Redwood City CA), Post-surgical applications for bioerodible polymers.
  21. Theeuwes Felix (Los Altos CA), System with microporous reservoir having surface for diffusional delivery of agent.
  22. Folkman Moses J. (18 Chathman Cir. Brookline MA 02146) Langer ; Jr. Robert S. (1200 Commonwealth ; Apt. 2 Allston MA 02134), Systems for the controlled release of macromolecules.
  23. Folkman Moses J. (Brookline MA) Langer ; Jr. Robert S. (Allston MA), Systems for the controlled release of macromolecules.

이 특허를 인용한 특허 (29)

  1. Siegel, Steven; Winey, Karen, 9-OH-risperidone controlled release composition.
  2. Siegel, Steven; Winey, Karen, Drug-containing PLA implants and methods of use thereof.
  3. Siegel, Steven; Winey, Karen, Drug-containing implants and methods of use thereof.
  4. Siegel, Steven; Winey, Karen, Drug-containing implants and methods of use thereof.
  5. Siegel, Steven; Winey, Karen, Drug-containing implants and methods of use thereof.
  6. Siegel, Steven; Winey, Karen, Drug-containing implants and methods of use thereof.
  7. Patel, Rajesh A.; Bhonsle, Sunil R., Heterogeneous implantable devices for drug delivery.
  8. Patel, Rajesh A.; Bhonsle, Sunil R., Heterogeneous implantable devices for drug delivery.
  9. Patel, Rajesh A.; Bucalo, Louis R.; Costantini, Lauren; Kleppner, Sofie, Implantable polymeric device for sustained release of dopamine agonist.
  10. Patel, Rajesh A.; Bucalo, Louis R.; Costantini, Lauren; Kleppner, Sofie, Implantable polymeric device for sustained release of dopamine agonist.
  11. Siegel, Steven; Winey, Karen, Method of maintaining therapeutic risperidone levels in a PLA:PLGA implant.
  12. Lozano, Andres M.; Mayberg, Helen S., Method of treating depression, mood disorders and anxiety disorders using neuromodulation.
  13. Lozano, Andres M; Mayberg, Helen S, Method of treating depression, mood disorders and anxiety disorders using neuromodulation.
  14. Lozano, Andres M; Mayberg, Helen S, Method of treating depression, mood disorders and anxiety disorders using neuromodulation.
  15. Lozano, Andres M; Mayberg, Helen S, Method of treating depression, mood disorders and anxiety disorders using neuromodulation.
  16. Lozano,Andres M.; Mayberg,Helen S., Method of treating depression, mood disorders and anxiety disorders using neuromodulation.
  17. Velasco,Francisco; Jimenez,Fiacro; Velasco,Marcos; Lozano,Andres M., Method of treating mood disorders and/or anxiety disorders by brain stimulation.
  18. Holoshitz,Joseph; Ling,Song, Methods and compositions for the treatment of diseases associated with signal transduction aberrations.
  19. Ghatnekar, Gautam S.; Brower, Justin, Methods and compositions for the treatment of metabolic disorders.
  20. Baker Keith ; Kieras Mark ; Redmon Martin ; Pratt Daniel, Methods for universally distributing therapeutic agents to the brain.
  21. Sloan, Leif R., Neural stimulation and optical monitoring systems and methods.
  22. Boland, Edward J.; McDonough, Joe, Phenothiazine enantiomers as agents for the prevention of bone loss.
  23. Siegel, Steven J.; Winey, Karen I.; Gur, Raquel E.; Lenox, Robert H., Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use.
  24. Siegel, Steven J.; Winey, Karen I.; Gur, Raquel E.; Lenox, Robert H., Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use.
  25. Siegel, Steven; Winey, Karen, Risperidone-containing PLA:PGA implants and methods of use thereof.
  26. Siegel, Steven; Winey, Karen, Risperidone-containing implants and methods of use thereof.
  27. Kilgard Michael P. ; Merzenich Michael M., System for stimulating brain plasticity.
  28. Hulvershorn, Justin; Fowler, Brad; Gliner, Bradford Evan; Sloan, Leif R.; Kopell, Brian; Soltysik, David Alan, Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders.
  29. Aung-Din, Ronald, Topical therapy for the treatment of migraines, muscle sprains, muscle spasms, spasticity and related conditions.
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