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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0146504 (1993-11-01) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 826 인용 특허 : 0 |
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biop
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micromachining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific microlocations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.
An electronic device adapted to receive a solution comprising: a substrate, a plurality of selectively addressable electrodes, the electrodes being disposed upon the substrate and electrically insulated from one another prior to receipt of the solution, a current source for providing a selective cur
An electronic device adapted to receive a solution comprising: a substrate, a plurality of selectively addressable electrodes, the electrodes being disposed upon the substrate and electrically insulated from one another prior to receipt of the solution, a current source for providing a selective current for the electrodes, individual buffer reservoirs associated with said electrodes, and individual permeation layers disposed adjacent said individual buffer reservoirs, forming addressable binding locations.
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