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Compositions and methods for enhanced drug delivery 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/70
  • A61K-031/00
출원번호 US-0449188 (1995-05-24)
발명자 / 주소
  • Hale Ron L. (Woodside CA) Lu Amy (Los Altos CA) Solas Dennis (San Francisco CA) Selick Harold E. (Belmont CA) Oldenburg Kevin R. (Fremont CA) Zaffaroni Alejandro C. (Atherton CA)
출원인 / 주소
  • Affymax Technologies N.V. (Middlesex GB2 03)
인용정보 피인용 횟수 : 200  인용 특허 : 27

초록 ▼

The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and de

대표청구항 ▼

An iontophoretic drug delivery system for administering a pharmaceutical agent to a patient comprising: (a) a pharmaceutical agent-chemical modifier complex comprising: a pharmaceutical agent, suitable for transdermal transport at therapeutically effective doses of less than 50 milligrams per day, h

이 특허에 인용된 특허 (27)

  1. Taglialatela Giulio (Rome ITX) Fanto Nicola (Rome ITX) Santaniello Mos (Casoria ITX) Cavazza Claudio (Rome ITX), Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same for promoting regeneration o.
    상세보기
  2. Ecanow Bernard (Wilmette IL), Drug delivery compositions and methods.
    상세보기
  3. Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Gyory J. Richard (Los Altos CA), Electrotransport transdermal system.
    상세보기
  4. Theeuwes Felix (Los Altos CA), Formulation chamber with exterior electrotransport delivery device.
    상세보기
  5. Schiffman Elliott (Chevy Chase MD) Altman Leonard C. (Seattle WA), Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections.
    상세보기
  6. Bodor Nicolae S. (Lawrence KS), Labile quaternary ammonium salts as prodrugs.
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  7. Shaw Jane (Atherton CA) Gale Robert M. (Mountain View CA), Method for treating ischemic conditions.
    상세보기
  8. Vainshtein Viktor A. (Suzdalsky prospekt ; 28 ; korpus 1 ; kv. 64 Piskarevsky prospekt ; 39 ; kv. 20 SUX) Kulbakh Valter O. (ulitsa Bukharestskaya ; 86 ; korpus 1 ; kv. 85 Piskarevsky prospekt ; 39 ;, N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition.
    상세보기
  9. Gilvarg Charles (Princeton NJ) Kingsbury William D. (King of Prussia PA), Oligopeptide prodrugs.
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  10. Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
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  11. Sipos, Tibor, Potentiated medicaments.
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  12. Huston James S. (Newton MA) Charette Marc F. (West Roxbury MA) Cohen Charles M. (Medway MA) Crea Roberto (Boston MA) Keck Peter C. (Millbury MA) Oppermann Hermann (Medway MA) Rueger David C. (West Ro, Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage.
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  13. Ledger Philip W. (Mountain View CA) Cormier Michel J. N. (Mountain View CA) Amkraut Alfred (Palo Alto CA), Reduction or prevention of sensitization to drugs.
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  14. Falkowski Leonard (Gdansk PLX) Kowszyk-Gindifer Zuzanna (Warsaw PLX) Plociennik Zofia (Warsaw PLX) Zielinski Jan (Gdansk PLX) Dahlig Halina (Warsaw PLX) Golik Jerzy (Sopot PLX) Jakobs Ewa (Sopot PLX), Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their.
    상세보기
  15. Cheng Yu-Ling (Cupertino CA) Gale Robert M. (Los Altos CA) Sugihara Edna (Mountain View CA) Sanders Harold F. (San Jose CA), Skin permeation enhancer compositions using sucrose esters.
    상세보기
  16. Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions, and methods and transdermal systems associated therewith.
    상세보기
  17. Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
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  18. Katz Martin (Menlo Park CA) Nacht Sergio (Los Altos CA) Heller Jorge (Woodside CA), System and method for transdermal drug delivery.
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  19. Pang Roy H. L. (Medway MA), Thrombus specific conjugates.
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  20. Gale Robert M. (Los Altos CA) Goetz Victor (Palo Alto CA) Lee Eun S. (Redwood City CA) Taskovich Lina T. (Palo Alto CA) Yum Su I. (Los Altos CA), Transdermal administration of fentanyl and device therefor.
    상세보기
  21. Gale Robert M. (Los Altos CA) Enscore David J. (Sunnyvale CA) Nedberge Diane E. (Los Altos CA) Nelson Melinda (Sunnyvale CA) Cheng Yu-Ling (Cupertino CA) Libicki Shari B. (Palo Alto CA), Transdermal administration of progesterone, estradiol esters, and mixtures thereof.
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  22. Nedberge Diane E. (Los Altos CA) Campbell Patricia S. (Palo Alto CA) Gale Robert M. (Los Altos CA) Yum Su I. (Los Altos CA), Transdermal contraceptive formulations.
    상세보기
  23. Gale Robert M. (Los Altos CA) Enscore David J. (Sunnyvale CA), Transdermal delivery of drugs from an aqueous reservoir.
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  24. Gale Robert M. (Los Altos CA) Enscore David J. (Sunnyvale CA), Transdermal delivery of highly ionized fat insoluble drugs.
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  25. Nelson Gregory R. (St. Paul MN) Zerbe Horst-Georg (St. Paul MN) Moore Cheryl L. (St. Paul MN) Wick Steven M. (St. Paul MN), Transdermal estradiol delivery system.
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  26. Zezza Fabio (Rome ITX), Use of esters of acyl L-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the trea.
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  27. Falkowski Leonard (Gdansk PLX) Stefanska Barbara (Gdansk-Oliwa PLX) Zielinski Jan (Gdansk-Oliwa PLX) Troka Elzbieta (Gdansk-Oliwa PLX) Golik Jerzy (Sopot PLX) Kolodziejczyk Pawel (Gdansk-Wrzeszcz PLX, Water-soluble salts of trimethylammonium derivatives of polyene macrolide antibiotics and the preparation thereof.
    상세보기

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