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DNA photocleavage using texaphyrins 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/40
  • A61K-031/555
출원번호 US-0469177 (1995-06-06)
발명자 / 주소
  • Magda Darren (Cupertino CA) Sessler Jonathan L. (Austin TX) Iverson Brent L. (Austin TX) Sansom Petra I. (Austin TX) Wright Meredith (San Jose CA)
출원인 / 주소
  • Pharmacyclics, Inc. (Sunnyvale CA 02) Board of Trustees, Univ. of TX Sys. (Austin TX 02)
인용정보 피인용 횟수 : 38  인용 특허 : 29

초록 ▼

Methods of cleavage of a polymer of deoxyribonucleic acid using photosensitive texaphyrins are disclosed. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a

대표청구항

A method of light-induced cleavage of a polymer of deoxyribonucleic acid, the method comprising: contacting the polymer with a photosensitive texaphyrin; and exposing the photosensitive texaphyrin to light for a time sufficient to cleave the polymer.

이 특허에 인용된 특허 (29)

  1. Sieber Fritz (Brookfield WI), Antiviral method, agents and apparatus.
    상세보기
  2. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Aromatic pentadentate expanded porphyrins in magnetic resonance imaging.
    상세보기
  3. Frame Robert R. (Ten UOP Plz. ; Algonquin & Mt. Prospect Rds. Des Plaines IL 60016), Catalytic composite, and method of manufacture.
    상세보기
  4. Gries Heinz (Berlin DEX) Rosenberg Douwe (Berlin DEX) Weinmann Hanns-Joachim (Berlin DEX), Diagnostic media.
    상세보기
  5. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles.
    상세보기
  6. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Nagara JPX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles.
    상세보기
  7. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumors.
    상세보기
  8. Sessler Jonathan L. (Austin TX) Toshiaki Murai (Gifu TX JPX) Hemmi Gregory W. (Austin TX), Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles for singlet oxygen production.
    상세보기
  9. Lauffer Randall B. (Boston MA) Brady Thomas J. (Winchester MA), Hepatobiliary NMR contrast agents.
    상세보기
  10. Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA) Krl Vladimir (Na Kozaaoa CSX), Hydroxylated texaphyrins.
    상세보기
  11. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Metal complexes of water soluble texaphyrins.
    상세보기
  12. Judy Millard M. (Dallas TX) Matthews James L. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Franklin (Dallas TX), Method for eradicating infectious biological contaminants in body tissues.
    상세보기
  13. Judy Millard M. (Dallas TX) Matthews James L. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Franklin (Dallas TX), Method for eradicating infectious biological contaminants in body tissues.
    상세보기
  14. Gries Heinz (Berlin DEX) Rosenberg Douwe (Berlin DEX) Weinmann Hanns-Joachim (Berlin DEX) Speck Ulrich (Berlin DEX) Mtzel Wolfgang (Berlin DEX) Hoyer Georg-Alexander (Berlin DEX) Pfeiffer ; deceased , Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules.
    상세보기
  15. Burrows Cynthia J. (Stony Brook NY) Rokita Steven E. (Port Jefferson NY) Chen Xiaoying (Stony Brook NY), Modification of DNA and oligonucleotides using metal complexes of polyaza ligands.
    상세보기
  16. Nguyen Thanh T. (Tigy FRX) Helene Claude (Saint Cyr en Val FRX) Asseline Ulysse (La Source FRX), Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis a.
    상세보기
  17. Hirschfeld Tomas B. (Livermore CA), Nucleic acid assay method.
    상세보기
  18. Meunier Bernard (Castanet FRX) Labat Gilles (Toulouse FRX) Seris Jean-Louis (Jurancon FRX), Oxidation catalysts based on supported metalloporphyrin.
    상세보기
  19. Matthews J. Lester (Dallas TX) Judy Millard M. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Frank (Dallas TX) Sessler Jonathan L. (Austin TX) Harriman Anthony (Austin TX) Maiya Bhaskar , Photodynamic viral deactivation with sapphyrins.
    상세보기
  20. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Murai Toshiaki (Gifu JPX), Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles.
    상세보기
  21. Wentland Mark P. (Colonie NY), Quinolonecarboxamide compounds, their preparation and use as antivirals..
    상세보기
  22. Sessler Jonathan L. (Austin TX) Cyr Michael J. (Austin TX), Sapphyrins, derivatives and syntheses.
    상세보기
  23. Therien Michael J. (Philadelphia PA) DiMagno Stephen G. (Philadelphia PA), Substituted porphyrins, porphyrin-containing polymers, and synthetic methods therefor.
    상세보기
  24. Bommer Jerry C. (Ogden UT) Burnham Bruce F. (Logan UT), Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents.
    상세보기
  25. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Tumor imaging and treatment by water soluble texaphyrin metal complexes.
    상세보기
  26. Lauffer Randall B. (Boston MA), Vivo enhancement of NMR relaxivity.
    상세보기
  27. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Water soluble texaphyrin metal complexes for singlet oxygen production.
    상세보기
  28. Sessler Jonathan L. (Austin TX) Hemmi Gregory W. (Austin TX) Mody Tarak D. (Austin TX), Water soluble texaphyrin metal complexes for viral deactivation.
    상세보기
  29. Levy Julia G. (Vancouver CAX) Dolphin David (Vancouver CAX) Chow Jack K. (Burnaby CAX), Wavelength-specific cytotoxic agents.
    상세보기

이 특허를 인용한 특허 (38)

  1. Ullman, Edwin F.; Singh, Rajendra; De Keczer, Steve; Davalian, Dariush, Amplified signal in binding assays.
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  2. Joseph C. Kaufman ; Matthew E. Roth ; Paul M. Lizardi ; Li Feng ; Darin R. Latimer, Binary encoded sequence tags.
    상세보기
  3. Kaufman, Joseph C.; Roth, Matthew E.; Lizardi, Paul M.; Feng, Li; Latimer, Darin R., Binary encoded sequence tags.
    상세보기
  4. Barton Jacqueline K. ; Jackson Brian A. ; Hudson Brian P., Detection and treatment of duplex polynucleotide damage.
    상세보기
  5. Emanuel,George, Efficient method and apparatus for generating singlet delta oxygen at an elevated pressure.
    상세보기
  6. Emanuel,George, Efficient method and apparatus for generating singlet delta oxygen at an elevated pressure.
    상세보기
  7. Lizardi Paul M. ; Roth Matthew E. ; Feng Li ; Guerra Cesar E. ; Weber Shane C. ; Kaufman Joseph C. ; Latimer Darin R., Fixed address analysis of sequence tags.
    상세보기
  8. Lizardi, Paul M.; Roth, Matthew E.; Feng, Li; Guerra, Cesar E.; Weber, Shane C.; Kaufman, Joseph C.; Latimer, Darin R., Fixed address analysis of sequence tags.
    상세보기
  9. Madden, Hugo; Hemmi, Greg; Mody, Tarak, High-purity texaphyrin metal complexes.
    상세보기
  10. Reddy,Heather; Goodrich,Raymond P., Inactivation of West Nile virus and malaria using photosensitizers.
    상세보기
  11. Goodrich, Raymond P.; Keil, Shawn D., Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light.
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  12. Platz Matthew Stewart ; Goodrich ; Jr. Raymond Paul, Isoalloxazine derivatives to neutralize biological contaminants.
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  13. Platz, Matthew Stewart; Goodrich, Jr., Raymond Paul, Isoalloxazine derivatives to neutralize biological contaminants.
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  14. Stuart W. Young ; Meredith Wright ; Jonathan L. Sessler ; Tarak D. Mody ; Darren Magda, Membrane incorporation of texaphyrins.
    상세보기
  15. Mody, Tarak D.; Galanter, Joshua, Metallotexaphyrin derivatives.
    상세보기
  16. Mody,Tarak D.; Galanter,Joshua, Metallotexaphyrin derivatives.
    상세보기
  17. Goodrich ; Jr. Raymond Paul ; Corbin ; III Frank ; Wood ; Jr. Edward C., Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers.
    상세보기
  18. Goodrich, Jr.,Raymond Paul; Hlavinka,Dennis, Method and apparatus for inactivation of biological contaminants using photosensitizers.
    상세보기
  19. Dumont,Larry Joe; Goodrich, Jr.,Raymond P., Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer.
    상세보기
  20. Emanuel, George, Method of treating biological and chemical agents with gas phase, electronically excited states of oxygen.
    상세보기
  21. Barton, Jacqueline K.; Junicke, Henrik, Methods and compositions for detecting polynucleotide duplex damage and errors.
    상세보기
  22. Barton,Jacqueline K.; Junicke,Henrik, Methods and compositions for detecting polynucleotide duplex damage and errors.
    상세보기
  23. Elliot R. Ramberg, Methods and compositions for detection of specific nucleotide sequences.
    상세보기
  24. Edrich, Richard Alan; Goodrich, Laura; Antwiler, Glen Delbert, Methods for uniformly treating biological samples with electromagnetic radiation.
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  25. Collis, Matthew, Multiple fluorophore detector system.
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  26. Mody,Tarak D.; Galanter,Joshua, Non-symmetric tripyrranes in the synthesis of novel macrocycles.
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  27. Magda Darren ; Crofts Shaun P. ; Wright Meredith, Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof.
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  28. Sessler Jonathan L. ; Mody Tarak D. ; Hemmi Gregory W., Pharmaceutical compositions comprising texaphyrins.
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  29. Magda Darren ; Sessler Jonathan L. ; Crofts Shaun P., Phosphoramidite derivatives of macrocycles.
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  30. Voet, Martin A., Photodynamic therapy for pre-melanomas.
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  31. Goodrich, Raymond P.; Li, Junzhi, Preventing transfusion related complications in a recipient of a blood transfusion.
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  32. Goodrich, Raymond P.; Li, Junzhi, Preventing transfusion related complications in a recipient of a blood transfusion.
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  33. Sessler Jonathan L. ; Harriman Anthony,FRX ; Miller Richard A. ; Magda Darren ; Mody Tarak D. ; Hemmi Gregory W., Radiation sensitization using texaphyrins.
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  34. Hlavinka, Dennis J.; Goodrich, Raymond P.; Reddy, Heather, Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light.
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  35. Zhang, Xiao-An; Jasanoff, Alan Pradip; Lippard, Stephen J., Sensors for fluorescence and magnetic resonance imaging.
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  36. Sessler Jonathan L. ; Hemmi Gregory W. ; Mody Tarak D. ; Magda Darren ; Kral Vladimir A.,CZX, Texaphyrins substituted with imidazole are provided.
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  37. Woodburn Kathryn W. ; Young Stuart W., Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma.
    상세보기
  38. Goodrich,Raymond P.; Platz,Matthew S.; Martin,Christopher B., Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components.
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