Vogel Emanuel (Cologne DEX) Mueller Martin (Cologne DEX) Halpern Otto (Gerona ESX) Cross Alexander D. (Atherton CA)
출원인 / 주소
Cytopharm, Inc. (Menlo Park CA 02)
인용정보
피인용 횟수 :
7인용 특허 :
19
초록
Porphycene compounds having the formula [Figure] wherein each R is -(CH2)n-X, n=1-10, X is OR1 and R1 is alkyl, aralkyl or aryl are useful as photosensitizer compounds in photodynamic therapy.
대표청구항▼
A porphycene of the formula: [Figure] wherein each R is, independently, -(CH2)n-X, n=1-10, X is OR1, and R1 is alkyl, aralkyl or aryl; R2 is (1) hydroxy, alkoxy or OCOR3, wherein R3 is -(CH2)m-Y, m=1-10 and Y is: (a) hydrogen or halogen, (b) C(O)OR4, wherein R4 is hydrogen, alkyl, aryl, aralkyl, cyc
A porphycene of the formula: [Figure] wherein each R is, independently, -(CH2)n-X, n=1-10, X is OR1, and R1 is alkyl, aralkyl or aryl; R2 is (1) hydroxy, alkoxy or OCOR3, wherein R3 is -(CH2)m-Y, m=1-10 and Y is: (a) hydrogen or halogen, (b) C(O)OR4, wherein R4 is hydrogen, alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, (c) NR5R6 wherein R5 and R6, independently, are hydrogen, alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, (d) NR4R5R6+A31 , wherein A31 is an anion and R4, R5 and R6 are as defined above, (e) NHC(O)OR4, wherein R4 is as defined above; or R2 is (2): OC(O)R7, wherein R7 is substituted or unsubstituted aryl or -CHR8〓CHR9-R10, R8 and R9 are, independently, hydrogen or C1-6 alkyl, and R10 is alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl; or R2 is (3): (a) NR11R12, wherein R11 and R12 independently, are hydrogen, alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, (b) NHCO-(CH2)p13 Z, wherein p=1-10 and Z is H, OH, NR11R12, C(O)OR4, OC(O)R4, C(O)NHR4 or NHC(O)OR4, wherein R4, R11 and R12 are as defined above; or R2 is (4): [Figure] (III) wherein L is -OC(O)-or -NHC(O)-; salts or metal complexes thereof, provided that said porphycene is not 9-acetoxy-2,7,12,17-tetrakis (methoxyethyl) porphycene.
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