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High molecular weight polymer-based prodrugs 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/335
  • C07D-305/14
출원번호 US-0380873 (1995-01-30)
발명자 / 주소
  • Greenwald Richard B. (Somerset NJ) Pendri Annapurna (Matawan NJ)
출원인 / 주소
  • Enzon, Inc. (Piscataway NJ 02)
인용정보 피인용 횟수 : 160  인용 특허 : 0

초록

Water-soluble prodrugs of the formula: [Figure] (I) wherein: D is a biologically active nucleophile; M is X or Q; x is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y′; Y and Y′are oxygen or sulfur; R is a polyalkylene oxide; and Z is

대표청구항

A composition of the formula: [Figure] wherein: R1 is C6H5 or (CH3)3CO; R2 is H or CH3CO; and R3 is aryl, aralkyl or heteroaryl. A taxane-based composition, comprising the formula: [Figure] wherein: R1 is C6H5 (CH3)3CO; R2 is H or CH3CO; R3 is aryl, aralkyl or heteroaryl; M is X or Q; X is an electr

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