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Non-crosslinked protein particles for therapeutic and diagnostic use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-051/08
  • A61K-009/50
  • B01J-013/08
  • C12N-011/02
출원번호 US-0212546 (1994-03-14)
발명자 / 주소
  • Yen Richard C. K. (Glendora CA)
출원인 / 주소
  • Hemosphere, Inc. (Irvine CA 02)
인용정보 피인용 횟수 : 50  인용 특허 : 17

초록 ▼

Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of hemoglobin in the particle composition. Particles which are primarily hemoglobi

대표청구항 ▼

A suspension of particles of non-crosslinked and non-denatured albumin in a first aqueous medium, said particles being monodisperse in said suspension, and having a size range of from about 50 to about 5000 nanometers in diameter, said particles further containing hemoglobin in an amount sufficient

이 특허에 인용된 특허 (17)

  1. Yapel ; Jr. Anthony F. (Saint Paul MN), Albumin medicament carrier system.
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  2. Ecanow Bernard (Wilmette IL), Drug delivery compositions and methods.
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  3. Gibson Suzanne M. (Piscataway NJ) Strauss George (Piscataway NJ) Wasserman Bruce P. (Belle Mead NJ), Heat stable fat substitute compositions and process.
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  4. Ithakissios ; Dionyssis S., In vitro diagnostic test.
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  5. Oppenheim ; Richard Charles ; Marty ; Jennifer Joy ; Speiser ; Peter, Injectable compositions, nanoparticles useful therein, and process of manufacturing same.
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  6. Arai Motoharu (Tokyo JPX) Ito Masatsugu (Tokyo JPX), Lipid powder having cross-linked coating thereon and process for preparing same.
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  7. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
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  8. Hunziker Ernst B. (Riedholz CHX), Method and compositions for the treatment and repair of defects or lesions in cartilage.
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  9. Ekman Bo (MalmSEX) Lindahl ke (Skurup SEX), Method for producing small, spherical polymer particles.
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  10. Senyei Andrew E. (Chicago IL) Widder Kenneth J. (Chicago IL), Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres.
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  11. Spence Kemet D. (Potlatch ID) Andrews Robert E. (Pullman WA), Microbial insecticide.
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  12. Chen Wehn-Sherng (Glenview IL) Henry George A. (Wilmette IL) Gaud Susan M. (Evanston IL) Miller Mark S. (Arlington Heights IL) Kaiser John M. (Glenview IL) Balmaceda Estela A. (Winnetka IL) Morgan Ro, Microfragmented ionic polysaccharide/protein complex dispersions.
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  13. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
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  14. Chia Han-Lie (Reinach CHX) Woltmann Siegfried (Magden CHX), Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use.
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  15. Devissaguet Jean-Philippe (Neuilly sur Seine FRX) Fessi Hatem (Paris FRX) Puisieux Francis (Maisons Alfort FRX), Process for the preparaton of dispersible colloidal systems of a substance in the form of nanocapsules.
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  16. Yen Richard C. K. (Glendora CA), Protein nanomatrixes and method of production.
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  17. Kunihiro Yasuyuki (Shinjuku JPX) Tanaka Ryo (Shinjuku JPX) Hata Seishichi (Shinjuku JPX) Yamada Koji (Shinjuku JPX), Thrombin composition for oral administration.
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  3. Quay,Steven C.; Brandt,Gordon, Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity.
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  4. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
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  5. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
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  6. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
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  7. Quay,Steven C, Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity.
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  8. Dellamary,Luis A.; Tarara,Thomas E.; Kabalnov,Alexey; Weers,Jeffry G.; Schutt,Ernest G., Dispersion for pulmonary delivery of a bioactive agent.
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  11. Yen Richard C. K., Fibrinogen-coated microspheres.
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