[특허]Testosterone prodrugs for improved drug delivery

Testosterone prodrugs for improved drug delivery 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/575
출원번호	US-0434892 (1995-05-04)
발명자 / 주소	Hale Ron L. (Woodside CA) Lu Amy T. (Los Altos CA) Solas Dennis W. (San Francisco CA) Cormier Michel J. N. (Mountain View CA)
출원인 / 주소	Affymax Technologies N.V. (Middlesex GB2 03) Alza Corporation (Palo Alto CA 02)
인용정보	피인용 횟수 : 64 인용 특허 : 0

초록 ▼

Compositions and methods are provided for enhanced transdermal electrotransport of 17-hydroxy sterol compounds, including testosterone. The parent sterols are modified at the 17-hydroxy position by covalent attachment of a charged chemical modifier. The chemical modifier provides the parent sterol with enhanced transport properties and is hydrolyzed under physiological conditions to release the active parent compound. The composition comprises a 17-hydroxy sterol/chemical modifier complex, more generally represented by the formula (sterol－O－)C(O)－R－N(R1)(R2)(R3)+. The portion of the complex derived from the chemical modifier is indicated by “C(O)－R－N(R1)(R2)(R3)+”, where N(R1)(R2)(R3)+represents a quaternary ammonium group and R1, R2, and R3 are independently selected from the group consisting of lower alkyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, and heteroarylalkyl; or R1 and R2 together with the nitrogen to which they are attached form a substituted heterocycle and R3 is lower alkyl, and R is a linking moiety, linking the (sterol－O)－C(O)－to the nitrogen atom.

대표청구항 ▼

A composition for use in iontophoretic delivery to a subject, comprising: a 17-hydroxy sterol/chemical modifier complex of the formula: (sterol－O－)C(O)－R－N(R1)(R2)(R3)+ where C(O)－R－N(R1)(R2)(R3)+represents the portion of the complex derived from the chemical modifier, －N(R1)(R2)(R3)+is a quarternary ammonium group and R1, R2, and R3are independently selected from the group consisting of lower alkyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, and heteroarylalkyl; or R1 and R2 together with the nitrogen to which the are attached form a substituted heterocycle and R3 is lower alkyl; R is a linking moiety, linking the (sterol－O－)－C(O)－to the nitrogen atom; where said complex is characterized by (i) a physiologically cleavable bond between the sterol and the chemical modifier, and (ii) enhanced iontophoretic transdermal uptake of the complex as compared to the 17-hydroxy sterol; wherein lower alkyl is selected from the group consisting of methyl, ethyl, n-propyl and isopropyl; wherein alkyl is selected from the group consisting of straight or branched alkyl chains having from 4 to 20 carbons; wherein cylcloalkyl is selected from the group consisting of cyclic alkyl ring structures having between 3 to 10 carbons; wherein R is selected from the group consisting of straight or branched acylalkyl chains and straight or branched acylalkyl chains with additional functional group or groups present internally; wherein said functionality is selected from the group consisting of carboxy, carbonate, carbamate, and amide; wherein R contains an oxygen atom or a nitrogen atom connected to the carbonyl carbon to provide a carbonate or carbamate linkage, respectively; wherein the chemical modifier/17-hydroxy sterol complex enhances the iotophoretic transport compared to said 17-hydroxy sterol alone. wherein said chemical modifier has a charge to mass ratio of at least one charge to 1000.

이 특허를 인용한 특허 (64)

Roberts, William J., 5-alkyl-7-alkylcarbonate-isoflavone ester and related method.
상세보기
Hale, Ron L.; Lei, Mingzu; Lloyd, Peter M.; Munzar, Patrik; Sharma, Krishnamohan; Solas, Dennis W.; Stracker, Matthew D., Aerosol drug delivery device incorporating percussively activated heat packages.
상세보기
Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Wensley, Martin J., Aerosol forming device for use in inhalation therapy.
상세보기
Wensley, Martin J.; Mufson, Daniel; Hodges, Craig C.; Lloyd, Peter M.; Rogers, Daniel D., Aerosol generating method and device.
상세보기
Wensley, Martin J.; Mufson, Daniel; Hodges, Craig C.; Lloyd, Peter M.; Rogers, Daniel D., Aerosol generating method and device.
상세보기
Song, Xuedong, Aqueous medium-sensitive coating compositions for triggered release of active ingredients and visual indication for wetness.
상세보기
Roberts, William J., Bioavailable prodrugs of androgenic steroids and related method.
상세보기
Kanios, David P.; Hartwig, Rod; Mantelle, Juan A.; Houze, David W., Compositions and methods for controlling drug loss and delivery in transdermal drug delivery systems.
상세보기
DiMauro, Thomas M., Curcumin derivatives.
상세보기
DiMauro, Thomas M., Curcumin-Resveratrol hybrid molecule.
상세보기
Rabinowitz, Joshua D.; Zaffaroni, Alejandro C., Delivery of drug esters through an inhalation route.
상세보기
Rabinowitz, Joshua D.; Zaffaroni, Alejandro C., Delivery of drug esters through an inhalation route.
상세보기
Rabinowitz,Joshua D.; Zaffaroni,Alejandro C., Delivery of drug esters through an inhalation route.
상세보기
Rabinowitz,Joshua D.; Zaffaroni,Alejandro C., Delivery of drug esters through an inhalation route.
상세보기
Every, Nathan R.; Hale, Ron L.; Lu, Amy T.; Rabinowitz, Joshua D., Diuretic aerosols and methods of making and using them.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Lu, Amy T.; Myers, Daniel J.; Rabinowitz, Joshua D.; Wensley, Martin J.; McKinney, Jeffrey A.; Zaffaroni, Alejandro C., Drug condensation aerosols and kits.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Lu, Amy T.; Myers, Daniel J.; Rabinowitz, Joshua D.; Wensley, Martin J.; McKinney, Jeffrey A.; Zaffaroni, Alejandro C., Drug condensation aerosols and kits.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Lu, Amy T.; Myers, Daniel J.; Rabinowitz, Joshua D.; Wensley, Martin J.; McKinney, Jeffrey A.; Zaffaroni, Alejandro C., Drug condensation aerosols and kits.
상세보기
Hale,Ron L.; Hodges,Craig C.; Lloyd,Peter M.; Lu,Amy T.; Myers,Daniel J.; Rabinowitz,Joshua D.; Wensley,Martin J., Drug condensation aerosols and kits.
상세보기
Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Dry deposition of materials for microarrays using matrix displacement.
상세보기
Zhang Lei ; Hofmann Gunter A. ; Rabussay Dietmar, Electrically assisted transdermal method and apparatus for the treatment of erectile dysfunction.
상세보기
Houze, David; Nguyen, Viet, Enhanced drug delivery in transdermal systems.
상세보기
Lilienfeld, Sean; Di Mauro, Thomas M., Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease.
상세보기
Lilienfeld, Sean; DiMauro, Thomas M, Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's disease.
상세보기
Hale, Ron L.; Song, Soonho; Quintana, Reynaldo J.; Rabinowitz, Joshua D.; Zaffaroni, Alejandro C., Method and apparatus for vaporizing a compound.
상세보기
Hale,Ron L.; Song,Soonho; Quintana,Reynaldo J.; Zaffaroni,Alejandro C.; Rabinowitz,Joshua D., Method and apparatus for vaporizing a compound.
상세보기
DiMauro, Thomas M., Method of administering a methylene blue-curcumin analog for the treatment of alzheimer's disease.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D., Method of forming an aerosol for inhalation delivery.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D., Method of forming an aerosol for inhalation delivery.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D., Method of forming an aerosol for inhalation delivery.
상세보기
Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D., Method of forming an aerosol for inhalation delivery.
상세보기
Raillard,Stephen P.; Zhou,Cindy X.; Yao,Fenmei; Manthati,Suresh Kumar; Xiang,Jia Ning; Gallop,Mark A., Methods for synthesis of acyloxyalkyl derivatives of GABA analogs.
상세보기
Raillard,Stephen P.; Zhou,Cindy X.; Yao,Fenmei; Manthati,Suresh Kumar; Xiang,Jia Ning; Gallop,Mark A., Methods for synthesis of acyloxyalkyl derivatives of GABA analogs.
상세보기
Gallop, Mark A.; Cundy, Kenneth C.; Zhou, Cindy X.; Yao, Fenmei; Xiang, Jia-Ning, Methods of using prodrugs of pregabalin.
상세보기
DiMauro, Thomas M., Methylated curcumin-resveratrol hybrid molecules for treating cancer.
상세보기
DiMauro, Thomas M., Methylene blue—curcumin analog for the treatment of alzheimer's disease.
상세보기
Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
상세보기
Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
상세보기
Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Microarrays and their manufacture.
상세보기
Anderson,N. Leigh; Anderson,Norman G.; Braatz,James A., Microarrays and their manufacture by slicing.
상세보기
Cross, Stephen D.; Herbette, Mathieu; Kelly, Andrew J. G.; Myers, Daniel J.; Shen, William W.; Timmons, Ryan D.; Tom, Curtis; Virgili, Justin M.; Wensley, Martin J., Multiple dose condensation aerosol devices and methods of forming condensation aerosols.
상세보기
Cross, Steven D.; Herbette, Mathieu; Kelly, Andrew J. G.; Myers, Daniel J.; Shen, William W.; Timmons, Ryan D.; Tom, Curtis; Virgili, Justin M.; Wensley, Martin J., Multiple dose condensation aerosol devices and methods of forming condensation aerosols.
상세보기
Wei, Ning; Song, Xuedong; Ryu, JinHo; Gil, JunMo, Non-tacky wetness indicator composition for application on a polymeric substrate.
상세보기
Gallop, Mark A.; Cundy, Kenneth C.; Zhou, Cindy X.; Qiu, Fayang G.; Yao, Fenmei; Xiang, Jia-Ning; Ollman, Ian R., Prodrugs of GABA analogs, compositions and uses thereof.
상세보기
Gallop, Mark A.; Cundy, Kenneth C.; Zhou, Cindy X.; Qiu, Fayang G.; Yao, Fenmei; Xiang, Jia-Ning; Ollmann, Ian R., Prodrugs of GABA analogs, compositions and uses thereof.
상세보기
Gallop, Mark A.; Cundy, Kenneth C.; Zhou, Cindy X.; Yao, Fenmei; Xiang, Jia-Ning, Prodrugs of GABA analogs, compositions and uses thereof.
상세보기
Gallop, Mark A.; Cundy, Kenneth C.; Zhou, Cindy X.; Yao, Fenmei; Xiang, Jia-Ning, Prodrugs of GABA analogs, compositions and uses thereof.
상세보기
Gallop, Mark A.; Cundy, Kenneth C.; Zhou, Cindy X.; Yao, Fenmei; Xiang, Jia-Ning; Ollman, Ian R.; Qiu, Fayang G., Prodrugs of GABA analogs, compositions and uses thereof.
상세보기
Gallop,Mark A.; Cundy,Kenneth C.; Zhou,Cindy X.; Qiu,Fayang Gregory; Yao,Fenmei; Xiang,Jia Ning; Ollman,Ian R., Prodrugs of GABA analogs, compositions and uses thereof.
상세보기
Gallop, Mark A., Prodrugs of gaba analogs, compositions and uses thereof.
상세보기
Hale, Ron L.; Lloyd, Peter M.; Lu, Amy; Myers, Daniel J.; Quintana, Reynaldo J.; Rabinowitz, Joshua D.; Solas, Dennis W.; Song, Soonho; Tom, Curtis; Wensley, Martin J., Rapid-heating drug delivery article and method of use.
상세보기
Damani, Ramesh; Hale, Ron L.; Myers, Daniel J.; Quintana, Reynaldo J.; Solas, Dennis W.; Song, Soonho; Soni, Pravin; Tom, Curtis; Sharma, Kirshnamohan, Self-contained heating unit and drug-supply unit employing same.
상세보기
Damani, Ramesh; Hale, Ron L.; Myers, Daniel J.; Quintana, Reynaldo J.; Solas, Dennis W.; Song, Soonho; Soni, Pravin; Tom, Curtis; Sharma, Krishnamohan, Self-contained heating unit and drug-supply unit employing same.
상세보기
Damani, Ramesh; Hale, Ron L.; Myers, Daniel J.; Quintana, Reynaldo J.; Solas, Dennis W.; Song, Soonho; Soni, Pravin; Tom, Curtis; Sharma, Krishnamohan, Self-contained heating unit and drug-supply unit employing same.
상세보기
Savage, Paul B.; Li, Chunhong, Steroid derived antibiotics.
상세보기
Savage, Paul B.; Li, Chunhong, Steroid derived antibiotics.
상세보기
Hale, Ron L.; Lu, Amy; Myers, Daniel J.; Rabinowitz, Joshua D.; Wensley, Martin J., Thin-film drug delivery article and method of use.
상세보기
Li, Chensheng; Nguyen, Viet, Transdermal administration of ACE inhibitors.
상세보기
Levin,Galit; Daniel,Dorit, Transdermal delivery system for anti-emetic medication.
상세보기
Levin,Galit; Stern,Meir; Daniel,Dorit, Transdermal delivery system for water insoluble drugs.
상세보기
Song, Xuedong, Triggerable compositions for two-stage, controlled release of active chemistry.
상세보기
Song, Xuedong; Weng, Yiming, Triggerable compositions for two-stage, controlled release of proactive chemistry.
상세보기
Anwar A. Hussain, Water soluble amine esters of testosterone for intranasal administration.
상세보기
Mori,Makoto; Kagoshima,Yoshiko; Uchida,Takuya; Konosu,Toshiyuki; Shibayama,Takahiro, Water-soluble triazole fungicide.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Testosterone prodrugs for improved drug delivery 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (64)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Testosterone prodrugs for improved drug delivery 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허를 인용한 특허 (64)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트