Rapidly disintegrating sheet-like presentations of multiple dosage units
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-007/00
A61K-009/42
A61K-009/70
출원번호
US-0300115
(1994-09-02)
우선권정보
DE-4018247 (1990-06-07)
발명자
/ 주소
Horstmann Michael (Neuwied DEX) Laux Wolfgang (Dietz DEX) Hungerbach Stefan (Nortershausen DEX)
출원인 / 주소
LTS Lohmann Therapie-Systeme GmbH & Co. KG (Neuwied DEX 03)
인용정보
피인용 횟수 :
101인용 특허 :
6
초록▼
A presentation which, in the form of a film, permits the individual dosage of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The presentation is characterized by the fact that it comprises a mass of 20 to 60%-wt. of at least a film former, 2 to 40%-wt. of at
A presentation which, in the form of a film, permits the individual dosage of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The presentation is characterized by the fact that it comprises a mass of 20 to 60%-wt. of at least a film former, 2 to 40%-wt. of at least a gel former, 0.1 to 35%-wt. of at least an active substance, and up to 40%-wt. of an inert filling agent, being applied on a carrier, or by consisting of a mass having the aforementioned composition but is unsupported. In the production thereof, an intimate mixture of said components is prepared, optionally with the addition of up to 30%-wt. of a polar solvent, and processed to form a homogeneous, spreadable or extrudable mass.
대표청구항▼
A sheet comprising multiple dosage units which disintegrate in water and which contain as active substance, a cosmetic, perfrming or flavoring application, and comprising a mass of (a) 20-60%-wt. of at least one film-forming agent, (b) 2-40%-wt. of at least one gel-forming agent, (c) 0.1-35%-wt. of
A sheet comprising multiple dosage units which disintegrate in water and which contain as active substance, a cosmetic, perfrming or flavoring application, and comprising a mass of (a) 20-60%-wt. of at least one film-forming agent, (b) 2-40%-wt. of at least one gel-forming agent, (c) 0.1-35%-wt. of at least one active substance and (d) up to 40%-wt. of at least one inert filling agent, the percentage relating to the solvent-free mass of these four components and the dosage units being supported on a carrier, wherein the film former comprises a compound selected from the group consisting of monomeric and oligomeric sugars, sugar alcohols, organic acids having up to 6 carbon atoms and polyethylene glycol, wherein the gel former is water swellable and consists of at least one component selected from the group consisting of polymeric carbohydrates, esters thereof, gelatin, albumin, collagen, egg white, carboxyvinyl copolymers, polyacryl amide, polyvinyl pyrrolidone and polyvinyl alcohol, wherein the filler comprises at least one physiologically acceptable compound selected from the group consisting of carbonates, phosphates, silicates, sulfates and oxides of an alkaline earth metal, silicas, slightly soluble sugars, cellulose, cyclodextrin as a starch derivative, talc, titanium dioxide, zinc oxide and magnesium stearate, undissolved or crystalline partial amounts of active substances simultaneously acting as filling agents, and wherein the layer thickness of the dosage units is from 0.003 to 4 mm.
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이 특허에 인용된 특허 (6)
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Davidson, R. Steven, Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals.
Bess,William S.; Kulkarni,Neema; Ambike,Suhas H.; Ramsay,Michael P., Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1.
Davidson, Robert S., Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films.
Davidson, Robert Steven, Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films.
Horstmann, Michael; Laux, Wolfgang, Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid.
Davidson, Robert S.; Kehoe, Gary, Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use.
Theus, Jon Scott, Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein clearance using same.
Schobel, Alexander M.; Myers, Garry L.; Kendall, Keith Joseph; Rademacher, Thomas; Mous, Jan; Barry, Justin N. W.; Williams, Phillip; Barrientos, Africa Garcia, Nanoparticle film delivery systems.
Fuisz, Richard C.; Fuisz, Joseph M., Package, system and methods for custody and control of drugs, and method and composition for making an oral soluble film, containing at least one active agent.
Moneymaker, Ricky Dean; Klesman, Larry Scott; Theus, Jon Scott, Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens.
Yang, Robert K.; Fuiz, Richard C.; Myers, Garry L.; Fuiz, Joseph M., Process for making a film having a substantially uniform distribution of components.
Myers, Garry L.; Hilbert, Samuel D.; Boone, Bill J.; Bogue, B. Arlie; Sanghvi, Pradeep; Hariharan, Madhusudan, Sublingual and buccal film compositions.
Myers, Garry L.; Hilbert, Samuel D.; Boone, Bill J.; Bogue, B. Arlie; Sanghvi, Pradeep; Hariharan, Madhusudan, Sublingual and buccal film compositions.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom.
Yang,Robert K.; Fuisz,Richard C.; Myers,Gary L.; Fuisz,Joseph M., Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom.
Strickland, James A.; Atchley, Frank S.; Rossman, James M.; Desmarais, Armand J.; Williams, Scott A.; Miller, Tod J.; Johnson, Cherne W., Tobacco compositions.
Strickland, James A.; Atchley, Frank S.; Rossman, James M.; Desmarais, Armand J.; Williams, Scott A.; Miller, Tod J.; Johnson, Cherne W.; Due, Vernie A., Tobacco compositions.
Strickland, James A; Atchley, Frank S.; Rossman, James M.; Desmarais, Armand J.; Williams, Scott A.; Miller, Tod J.; Johnson, Cherne W.; Due, Vernie A., Tobacco compositions.
Williams, Scott A.; Strickland, James Arthur; Atchley, Frank Scott; Desmarais, Armand J.; Miller, Tod J.; Johnson, Cherne W.; Due, Vernie A., Tobacco compositions.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Uniform films for rapid dissolve dosage form incorporating taste-masking compositions.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Uniform films for rapid dissolve dosage form incorporating taste-masking compositions.
Yang, Robert K.; Fuisz, Richard C.; Myers, Garry L.; Fuisz, Joseph M., Uniform films for rapid dissolve dosage form incorporating taste-masking compositions.
Kato, Yoichi; Tsujimoto, Kazuhisa; Yamada, Hideyuki; Hamada, Taizo; Yuda, Sadayuki; Okano, Koichi, Use of sericin for improving the feeling in use of denture.
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