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특허 상세정보

MyON담기
내보내기 페이스북 공유 카카오톡 공유

Method for making freeze dried drug dosage forms

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/20   
미국특허분류(USC) 424/465 ; 424/464 ; 424/473 ; 424/484
출원번호 US-0481287 (1995-06-07)
국제출원번호 PCT/US94/07618 (1994-07-08)
§371/§102 date 19950607 (19950607)
국제공개번호 WO-9501782 (1995-01-19)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 111  인용 특허 : 14
초록
▼

The present invention discloses an improved technique for preparing a rapidly dispersing pharmaceutic tablet of a granular therapeutic agent which has both relatively low solubility and relatively large particle size. Xanthan gum is added to a liquid admixture of solvent, carrier components, and the granular therapeutic agent. The xanthan gum not only facilitates suspension of the granular therapeutic agent in the liquid admixture, but, more surprisingly, does so without adversely effecting the dispersion qualities and texture of the tablet in the patien...

대표
청구항
▼

A method of manufacturing a solid, shaped dosage form which disintegrates in lass than about 10 seconds upon contact with an aqueous media, said method including the preparation of a liquid admixture comprising a solvent, gelatin, a granular therapeutic agent having a particle size ranging from about 1 to about 400 microns and from 0.01 to 0.05 weight percent xanthan gum sufficient to act predominantly as a gelatin flocculating agent; filing said liquid admixture into one or more shaped depressions in a tray; freezing said liquid admixture in said trays ...

이 특허에 인용된 특허 (14)

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  10. Bod Pter (Gymro HUX) Harsnyi Klmn (Budapest HUX) Hegeds Bla (Budapest HUX) Bogsch Erik (Budapest HUX) Fekecs va (Budapest HUX) Pter Imre (Budapest HUX) Aracs nTrischler Zsuzsanna (Budapest HUX) Miszo. Process for the preparation of morphologically homogeneous forms of thiazole derivatives. USP1990014894459.
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