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Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of trea 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/785
  • A61K-038/00
출원번호 US-0344157 (1994-11-22)
발명자 / 주소
  • Saavedra Joseph E. (Thurmont MD) Keefer Larry K. (Bethesda MD) Roller Peter P. (Rockville MD) Akamatsu Miki (Rockville MD)
출원인 / 주소
  • The United States of America as represented by the Department of Health and Human Services (Washington DC 06)
인용정보 피인용 횟수 : 68  인용 특허 : 3

초록 ▼

A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2-functional group; pharmaceutical compositions comprising the

대표청구항 ▼

A polymeric composition capable of releasing nitric oxide, said composition comprising a biopolymeric backbone wherein said backbone is of a protein, and at least one nitric oxide-releasing N2O2-function group selected from the group consisting of X－N(O)NO]or [N(O)NO－X, wherein X is an organic moiet

이 특허에 인용된 특허 (3)

  1. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Complexes of nitric oxide with polyamines.
    상세보기
  2. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Complexes of nitric oxide with polyamines.
    상세보기
  3. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic.
    상세보기

이 특허를 인용한 특허 (68)

  1. Shami, Paul J.; Kosack, Ken M., Activated nitric oxide donors and methods of making and using thereof.
    상세보기
  2. Shami, Paul J.; Kosak, Ken M., Activated nitric oxide donors and methods of making and using thereof.
    상세보기
  3. Whitlock, David R.; Jamas, Spiros; Weiss, Larry, Ammonia oxidizing bacteria for treatment of acne.
    상세보기
  4. Whitlock, David R.; Jamas, Spiros; Weiss, Larry, Ammonia oxidizing bacteria for treatment of eczema.
    상세보기
  5. Whitlock, David R., Articles of clothing treated with ammonia oxidizing bacteria to produce nitric oxide.
    상세보기
  6. Fossel, Eric T., Beneficial effects of increasing local blood flow.
    상세보기
  7. Saavedra Joseph E. ; Keefer Larry K. ; Roller Peter P. ; Akamatsu Miki, Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same.
    상세보기
  8. Whitlock, David R., Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same.
    상세보기
  9. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  10. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  11. Fossel, Eric T., Delivery of ibuprofen and other compounds.
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  12. Carbone, Phil; Benedek, Karen; Ruffo, Michael O.; Luongo, Wade, Device and method for gas sterilization.
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  13. Carbone, Phil; Benedek, Karen; Ruffo, Michael O.; Luongo, Wade, Device and method for gas sterilization.
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  14. Stenzler, Alex, Device and method for treatment of surface infections with nitric oxide.
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  15. Stenzler, Alex, Device and method for treatment of surface infections with nitric oxide.
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  16. Stenzler, Alex; Miller, Christopher C., Device and method for treatment of surface infections with nitric oxide.
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  17. Stenzler, Alex; Miller, Chris C, Device and method for treatment of wounds with nitric oxide.
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  18. Fitzhugh, Anthony L.; Cafferata, Robert; Keefer, Larry K., Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use.
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  19. Fitzhugh,Anthony L.; Cafferata,Robert; Keefer,Larry K., Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use.
    상세보기
  20. Smith Daniel J. ; Rao Weisun, Hydrolytically unstable, biocompatible polymer.
    상세보기
  21. Shami, Paul, In vivo use of glutathione S-transferase activated nitric oxide donors.
    상세보기
  22. Matthew F. Ogle ; Peter S. Dardi, Medical devices that resist restenosis.
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  23. Stenzler, Alex; Miller, Christopher C.; McMullin, Bevin, Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing.
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  24. Bauman, Susanne; Stasko, Nathan A., Methods of decreasing sebum production in the skin.
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  25. Miller,Christopher; Stenzler,Alex, Nitric oxide decontamination of the upper respiratory tract.
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  26. West, Jennifer L.; Masters, Kristyn Simcha, Nitric oxide-producing hydrogel materials.
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  27. West,Jennifer L.; Bohl,Kristyn Simcha, Nitric oxide-producing hydrogel materials.
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  28. Joseph E. Saavedra ; Larry K. Keefer ; Peter P. Roller ; Miki Akamatsu, Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same.
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  29. Schoenfisch, Mark; Riccio, Daniel; Nugent, Julia; Stasko, Nathan, Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same.
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  30. Hrabie, Joseph A.; Citro, Michael L.; DeRosa, Frank; Keefer, Larry K., Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof.
    상세보기
  31. Hrabie, Joseph A.; DeRosa, Frank; Keefer, Larry K., Nitric oxide-releasing diazeniumdiolated compounds.
    상세보기
  32. Keefer,Larry K.; Hrabie,Joseph A., Nitric oxide-releasing medical devices.
    상세보기
  33. Fitzhugh Anthony L. ; Cheng Peiwen ; Saavedra Joseph ; Cafferata Robert ; Hendriks Marc,NLX ; Keefer Larry K. ; Tedeschi Eugene ; Verhoeven Michel L. P. M.,NLX, Nitric oxide-releasing metallic medical devices.
    상세보기
  34. Fitzhugh, Anthony L.; Cheng, Peiwen; Saavedra, Joseph; Cafferata, Robert; Hendriks, Marc; Keefer, Larry K.; Tedeschi, Eugene; Verhoeven, Michel I. P. M., Nitric oxide-releasing metallic medical devices.
    상세보기
  35. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing molecules.
    상세보기
  36. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing molecules.
    상세보기
  37. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  38. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  39. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  40. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
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  41. Schoenfisch, Mark H.; Shin, Jae Ho; Stasko, Nathan, Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications.
    상세보기
  42. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing polymers.
    상세보기
  43. Arnold, Ernst V.; Doletski, Blaine G.; Raulli, Robert E., Nitric oxide-releasing polymers.
    상세보기
  44. Saavedra,Joseph E; Keefer,Larry K, O-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1, 2-diolates.
    상세보기
  45. Saavedra, Joseph E.; Keefer, Larry K.; Srinivasan, Aloka; Rice, William G.; Ji, Xinhua; Bogdan, Christian, O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates.
    상세보기
  46. Saavedra, Joseph E.; Keefer, Larry K.; Srinivasan, Aloka; Bogdan, Christian; Rice, William G.; Ji, Xinhua, O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates.
    상세보기
  47. Fossel, Eric T., Systems and methods for treatment of allergies and other indications.
    상세보기
  48. Schoenfisch, Mark; Riccio, Daniel, Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same.
    상세보기
  49. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
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  50. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
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  51. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
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  52. Fossel, Eric T., Topical composition containing ibuprofen.
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  53. Fossel, Eric T., Topical composition containing naproxen.
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  54. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
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  55. Fossel, Eric T., Topical delivery of L-arginine to cause beneficial effects.
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  56. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Topical gels and methods of using the same.
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  57. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Topical gels and methods of using the same.
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  58. Fossel, Eric Thor, Transdermal delivery of beneficial substances effected by a hostile biophysical environment.
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  59. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  60. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  61. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  62. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  63. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  64. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  65. Fossel, Eric T., Treatment of erectile dysfunction and other indications.
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  66. Miller, Christopher C.; Hole, Douglas R.; Murray, Bruce R; Perry, Bryan, Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant.
    상세보기
  67. Hole, Douglas; Miller, Christopher C., Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma.
    상세보기
  68. Stasko, Nathan; Bauman, Susanne; Joshi, Pranav R., Wound dressings, methods of using the same and methods of forming the same.
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