IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
|
출원번호 |
US-0456796
(1995-06-01)
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발명자
/ 주소 |
- Kurtz Robert J. (New York NY) Fuller William D. (San Diego CA)
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출원인 / 주소 |
- Bioresearch, Inc. (Arlington VA 02)
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인용정보 |
피인용 횟수 :
27 인용 특허 :
0 |
초록
Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
대표청구항
▼
A composition comprising an eatable having at least one taste selected from bitter and metallic, and at least one tastand in a substantially tasteless amount of about 0.0000001 to about 300% by weight, based on the weight of the eatable, which amount is sufficient to reduce said at least one bitter
A composition comprising an eatable having at least one taste selected from bitter and metallic, and at least one tastand in a substantially tasteless amount of about 0.0000001 to about 300% by weight, based on the weight of the eatable, which amount is sufficient to reduce said at least one bitter and metallic taste, said tastand being selected from the group consisting of compounds which are substantially tasteless in the amount used and have the structure: [Figure] W-1 wherein r, 1, and m are 0 or 1; j and k are 0, 1, 2, or 3; each R2 and R3 which may be the same or different are independently selected from the group consisting of H, trifluoromethyl, halogen, cyano; and substituted or unsubstituted alkyl, alkylene, branched alkyl, branched alkylene, aryl, aralkyl, cycloalkyl, acyl, benzoyl, alkoxy, aryloxy, heterocyclic, polycyclic; each Y which may be the same or different is selected from N, O, and S; when r or m is 1 and Y is N, p or q are 2 or 3; when r or m is 1 and Y is N, p or q are 2 or 3; when r or m is 1 and Y is 0, p or q is 1; when r or m is 1 and Y is S, p is 1 or 2; A is selected from the group consisting of H, C〓O, O〓S〓O, S〓O, O〓P(H)OH, O〓P(OH)2, and O〓B(H)OH; Q is selected from the group consisting of H, trifluoromethyl, halogen, cyano; and substituted or unsubstituted alkyl, alkylene, branched alkyl, branched alkylene, aryl, aralkyl, cycloalkyl, acyl, benzoyl, alkoxy, aryloxy, heterocyclic, polycyclic; R′″and Q together may form a cyclic structure; any of the R3\s and Q together may form a cyclic structure; any of the R3\s and R′″together may form a cyclic structure; each R which may be the same or different when p>1 and each R′which may be the same or different when q>1 are independently selected from the group consisting of H, trifluoroacetyl, and substituted or unsubstituted alkyl, dialkyl, aralkyl, aryl, diaryl, acyl, cycloalkyl, benzoyl, alkyloxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, amidines, alkylamidines, arylamidines, a monosaccharide, a disaccharide, a trisaccharide, an oligosaccharide, phosphorylated saccharides, arylacyl, alkylene, heterocyclic, polycyclic; and one of the following three structures W-2: [Figure] W-2 [Figure] [Figure] wherein Y which may be the same or different is selected from N, O, and S; when d is 1, b is O and Y is N, e is 2 or when d is 1, b is O and Y is O, e is 1; f is 0,1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; when d is 1, b is O and Y is S, e is 1 or 2; A is selected from H, C〓O, O〓S〓O, S〓O, O〓P(H)OH or O〓P(OH)2, and O〓B(H)OH; Q is selected from the group consisting of H, trifluoromethyl, halogen, cyano; and substituted or unsubstituted alkyl, alkylene, branched alkyl, branched alkylene, aryl, aralkyl, cycloalkyl, acyl, benzoyl, alkoxy, aryloxy, heterocyclic, polycyclic; b is 0, 1, or 2 and c is or 1; Z and Z′are the same or different and are selected from -O-X+, OR″, NH2, NHR″and N(R″)2; R″is selected from alkyl, branched alkyl, aryl, aralkyl, alkaryl, cycloalkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted aralkyl and substituted alkaryl; R′″is selected from alkyl, branched alkyl, aryl, aralkyl, alkaryl, cycloalkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted aralkyl, substituted alkaryl, and an amino acid side chain; where CH-CH or CH2-CH2 bonds exist the level of unsaturation may be increased by removing one or more hydrogen atoms from each carbon atom participating in the CH-CH or CH2-CH2 bonds; and physiologically acceptable salts of all of the foregoing.
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