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Calcium mineral-based microparticles and method for the production thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/16
  • A61K-047/04
  • A01N-025/12
출원번호 US-0538635 (1995-10-04)
발명자 / 주소
  • Nuwayser Elie S. (Wellesley MA)
출원인 / 주소
  • Biotek, Inc. (Woburn MA 02)
인용정보 피인용 횟수 : 52  인용 특허 : 0

초록

A novel method of producing biodegradable microparticles is disclosed. Inorganic calcium salts are mixed with water to form a slurry. The slurry is then added to an oil bath which is then mixed to form an emulsion. The mixing continues for a period of time sufficient to form hardened microparticles.

대표청구항

A method for producing microparticles comprising the steps of, (a) mixing an inorganic calcium salt with water to form an inorganic calcium salt slurry, (b) combining the inorganic calcium salt slurry with a liquid substantially immiscible therewith, (c) mixing the inorganic calcium salt slurry with

이 특허를 인용한 특허 (52)

  1. Nivaggioli Thierry ; Colegrove George ; Flanagan John, Alginate and gellan gum as tablet coating.
  2. Robertson, Gavin P.; Madhunapantula, SubbRao V.; Amin, Shantu; Desai, Dhimant, Anti-cancer compositions and methods.
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  6. Robertson, Gavin P.; Sharma, Arati K.; Sharma, Arun K.; Amin, Shantu G.; Desai, Dhimant H., Anti-cancer compositions and methods.
  7. Robertson, Gavin P.; Sharma, Arati K.; Sharma, Arun K.; Amin, Shantu G.; Desai, Dhimant H., Anti-cancer compositions and methods.
  8. Maspero, Fabrizio Alessandro; Ruffieux, Kurt, Biocompatible bone implant compositions and methods for repairing a bone defect.
  9. Maspero, Fabrizio Alessandro; Ruffieux, Kurt, Biodegradable biocompatible implant.
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  22. Kumar, Mukesh, Ceramic implants affording controlled release of active materials.
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  25. Ducheyne, Paul; Radin, Shulamith, Conditioning of bioactive glass surfaces in protein containing solutions.
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  29. Sylwester Gogolewski CH, Hardenable ceramic hydraulic cement.
  30. Nuwayser,Elie S., High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence.
  31. Bohner, Marc, Implant comprising calcium cement and hydrophobic liquid.
  32. Kaigler, Sr., Darnell, Implant pellets and methods for performing bone augmentation and preservation.
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  36. Nuwayser,Elie S., Multi-layered microcapsules and method of preparing same.
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  38. Zhong, Jipin; Gaisser, David M., Osteostimulative settable bone graft putty.
  39. Maspero, Fabrizio Alessandro; Ruffieux, Kurt, Porous biocompatible implant material and method for its fabrication.
  40. Gorman, Robert C.; Gorman, III, Joseph H.; Ryan, Liam P., Prevention of infarct expansion.
  41. El-Deiry, Wafik S.; Allen, Joshua E.; Wu, Gen Sheng, Small molecule TRAIL gene induction by normal and tumor cells as an anticancer therapy.
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  43. El-Deiry, Wafik S.; Allen, Joshua E.; Wu, Gen Sheng, Small molecule trail gene induction by normal and tumor cells as an anticancer therapy.
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  47. Lee, William W., Therapeutic calcium phosphate particles and methods of making and using same.
  48. Bell, Steve J. D.; Morcol, Tulin; He, Qing, Therapeutic calcium phosphate particles and methods of manufacture and use.
  49. Steve J. D. Bell ; Tulin Morco ; Qing He, Therapeutic calcium phosphate particles and methods of manufacture and use.
  50. Engbrecht, Dick C.; Liu, Qingxia; Shake, Michael P.; Wang, Xuming; Miller, David Paul; Bolind, Michael L.; Reed, Paul; Roelfs, Donald L.; Bury, Rafael, Water resistant cementitious article and method for preparing same.
  51. Gibson, John W.; Tipton, Arthur J.; Holl, Richard J.; Meador, Stacey, Zero-order prolonged release coaxial implants.
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