초록 ▼

Disclosed herein is a process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent, wherein a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and diss

Disclosed herein is a process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent, wherein a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is used to dissolve or disperse the agent and dissolve the polymer. The solvent blend containing the agent and polymer is dispersed in an aqueous solution to form microdroplets. The resulting emulsion is then added to an extraction medium preferably containing at least one of the solvents of the blend, whereby the rate of extraction of each solvent is controlled, whereupon the biodegradable microparticles containing the biologically active agent are formed.

대표청구항 ▼

A method for preparing biodegradable microparticles comprising: A. preparing a first phase comprising a biodegradable polymeric encapsulating binder, wherein said biodegradable polymeric encapsulating binder is selected from the group consisting of poly(glycolic acid), poly-D,L-lactic acid, poly-L-l

A method for preparing biodegradable microparticles comprising: A. preparing a first phase comprising a biodegradable polymeric encapsulating binder, wherein said biodegradable polymeric encapsulating binder is selected from the group consisting of poly(glycolic acid), poly-D,L-lactic acid, poly-L-lactic acid, copolymers of the foregoing, poly(lactic acid-caprolactone), and poly(glycolic acid-caprolactone), and a therapeutic active agent dissolved or dispersed in a blend of benzyl alcohol and at least one organic solvent miscible therewith, said blend being free from halogenated hydrocarbons and having limited water solubility, B. preparing an aqueous second phase, C. combining said first phase and said second phase under the influence of mixing means to form an oil in water emulsion in which said first phase is discontinuous and said second phase continuous, and D. isolating said discontinuous first phase in the form of microparticles.