IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0463753
(1995-06-05)
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발명자
/ 주소 |
- Kurtz Robert J. (New York NY) Fuller William D. (San Diego CA)
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출원인 / 주소 |
- Bioresearch, Inc. (Arlington VA 02)
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인용정보 |
피인용 횟수 :
24 인용 특허 :
18 |
초록
Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
대표청구항
▼
A composition comprising an eatable having at least one taste selected from bitter and metallic, and at least one tastand in a substantially tasteless amount of about 0.0000001 to about 300% by weight, based on the weight of the eatable, which amount is sufficient to reduce said at least one bitter
A composition comprising an eatable having at least one taste selected from bitter and metallic, and at least one tastand in a substantially tasteless amount of about 0.0000001 to about 300% by weight, based on the weight of the eatable, which amount is sufficient to reduce said at least one bitter and metallic taste, said tastand being selected from the group consisting of compounds which are substantially tasteless in the amount used and have the structure: [Figure] P-1 and tautomers thereof, wherein the substituents R and R3, which may be the same or different, are independently selected from the group consisting of H, hydroxy, nitro, cyano, halogen, COOH, SO3H, CH2SO2NH2, trifluoroacetyl, an acid group of the structure ZOqHr wherein Z is an element selected from the group consisting of carbon, sulfur, boron or phosphorus, q is an integer from 2 to 3 and r is an integer from 1 to 3; and an O, S, N or phosphorylated glycoside, where the glycoside is selected from the group consisting of monosaccharides, disaccharides, trisaccharides, and oligosaccharides all of which saccharides may be substituted; and the following groups which may be substituted or unsubstituted: amino, alkyl, alkoxy, aryl, alkylene, aminoacyl, aryloxy, aralkoxy, acyl, arylacyl, benzoyl, alkylamino, dialkylamino, trialkylamino, carbonates, alkylcarbonates, arylcarbonates, acylamino, guanidino, alkylguanidino, acylguanidino, arylguanidino, alkyurethanes, arylurethanes, ureas, alkylureas, CHO, COCH3, COCH3, CH2CHO, CH2COOH, COOCH3, OCOCH3, CONH2, NHCHO, SCH3, SCH2CH3, CH2SCH3, SO2NH2, SO2CH3, CH2SO3H, cycloalkyl, heterocyclic, polycyclic, arylureas, carboxylic acid ester, carboxamide, N-alkyl carboxamide, di-alkyl carboxamides, and wherein any two substituents taken together can be an aliphatic chain linked to a phenyl ring at one or more positions either directly via a carbon atom or indirectly via an oxygen, nitrogen or sulfur atom, to form a ring structure; R1 and R2, which may be the same or different, are independently selected from the group consisting of trifluoroacetyl, cyano, nitro; and the following groups which may be substituted or unsubstituted: alkyl, dialkyl, aralkyl, aryl, diaryl, acyl, cycloalkyl, benzoyl, alkyloxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl, amidines, alkylamidines, arylamidines, a monosaccharide, a disaccharide, a trisaccharide, an oligosaccharide, phosphorylated saccharides, arylacyl, alkylene, heterocyclic, polycyclic; where C〓C or C〓N bonds exist, the level of saturation may be decreased by substituting at the carbon and/or nitrogen atom one or more substituents independently selected from the group consisting of H, hydroxy, nitro, cyano, halogen, COOH, SO3H, CH2SO2NH2, trifluoroacetyl, an acid group of the structure ZOqHr wherein Z is an element selected from the group consisting of carbon, sulfur, boron or phosphorus, g is an integer from 2 to 3 and r is an integer from 1 to 3; and an O, S, N or phosphorylated glycoside, where the glycoside is selected from the group consisting of monosaccharides, disaccharides, trisaccharides, and oligosaccharides all of which saccharides may be substituted; and the following groups which may be substituted or unsubstituted: amino, alkyl, alkoxy, aryl, alkylene, aminoacyl, aryloxy, aralkoxy, acyl, arylacyl, benzoyl, alkylamino, dialkylamino, trialkylamino, carbonates, alkylcarbonates, arylcarbonates, acylamino, guanidino, alkylguanidino, acylguanidino, arylguanidino, alkyurethanes, arylurethanes, ureas, alkylureas, CHO, COCH3, COCH3, CH2CHO, CH2COOH, COOCH3, OCOCH3, CONH2, NHCHO, SCH3, SCH2CH3, CH2SCH3, SO2NH2, SO2CH3, CH2SO3H, cycloalkyl, heterocyclic, polycyclic, arylureas, carboxylic acid ester, carboxamide, N-alkyl carboxamide, di-alkyl carboxamides, and wherein any two substituents taken together can be an aliphatic chain linked to a phenyl ring at one or more positions either directly via a carbon atom or indirectly via an oxygen, nitrogen or sulfur atom to form a ring structure; and physiologically acceptable salts of all of the foregoing.
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