초록 ▼

An improved transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream embodying at least two electrode elements forming the applicator and with the electrodes separated from each other by insulating means. A reser

An improved transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream embodying at least two electrode elements forming the applicator and with the electrodes separated from each other by insulating means. A reservoir means, in at least one of said electrode elements of said applicator, containing said medicament; and a circuit, including a power source, for supplying electric power to said electrodes and such reservoir means. Suitable cover means partially enclosed at least said reservoir means, and adhesive means affixes the applicator to the skin, so as to complete an electrical circuit through the skin when the applicator is affixed thereto, thus creating at least one physico/chemical mass transfer phenomenon which causes said medicament to migrate through the skin.

대표청구항 ▼

A transdermal drug applicator in the form of a conformable flexible patch for application of at least ionic or non-ionic drug medicament through the skin into the blood stream of a living patient consisting of: a pair of electrodes comprising two reservoirs juxtaposed to each other for their full de

A transdermal drug applicator in the form of a conformable flexible patch for application of at least ionic or non-ionic drug medicament through the skin into the blood stream of a living patient consisting of: a pair of electrodes comprising two reservoirs juxtaposed to each other for their full depth, and joined as a structure, with each containing a medicament therein for application into the blood stream of said patient through respective areas of the skin beneath said two reservoirs when applied thereto; wherein full planar bottom surface areas of said reservoirs contact said skin when said applicator is in use; means comprising an electrical circuit having a source of electrical power for supplying electrical current to said two reservoirs to effect migration of said medicament through the skin of said patient into the blood stream of said patient; a flexible dam insulator in the form of an electrode barrier separator disposed between the two reservoirs for at least the full depth of said reservoirs, and being electrically insulative when said transdermal drug applicator is placed in use on the skin of said patient in intimate contact therewith, while isolating from each other the respective areas of the skin of said patient on which said two reservoirs are individually applied in order to effectively seal and isolate migration of medicament through said respective areas of the skin from each other, thereby precluding any electrical shorting effect due to any moisture on said skin; and flexible cover means wrapped about except for the portions intended to be placed against respective skin areas, and for holding at least said two reservoirs as a unitary side by side structure including electrically non-conductive means for defining an electrically non-conductive peripheral edge surface about the periphery of respective peripheral areas of the two reservoirs, and said unitary side by side structure being disposed in use in intimate contact with skin of said patient with said edge surface peripherally of said respective areas of said skin with which said two reservoirs are in contact so as to also effectively seal and isolate migration of a medicament from other areas of the skin of said patient peripherally adjacent respective areas of the skin on which said two reservoirs are applied; whereby said medicament is totally concentrated and corralled above said skin beneath said reservoirs and driven through said skin by means of an electrically induced mass transfer phenomena, and in no way forced laterally away from said respective areas of the skin when said two reservoirs are applied thereto; and wherein at least one of said reservoirs including a pair of medicament zones having a predetermined gradient concentration for providing optimum administration of said medicament to the living patient with a controlled pH.