초록 ▼

An improved apparatus for the iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane so the medication can be absorbed by the adjacent tissues and blood vessels. The apparatus can be adapted for large dermal area application or for a smal

An improved apparatus for the iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane so the medication can be absorbed by the adjacent tissues and blood vessels. The apparatus can be adapted for large dermal area application or for a smaller area of application, depending on the choice of specific electrode employed. The apparatus comprises a multichannel iontophoretic applicator electrode. Multiple piezoelectric elements are mounted on the ionotophoetic electrode. The combination of ultrasonic vibration and iontophoresis creates a significant improvement in the penetration of medicament in contact with the skin or mucous membrane underlying the electrode. Drug delivery systems employing biofeedback such as the transcutaneous delivery of insulin based on tissue glucose are outlined based on this ionosonic technology.

대표청구항 ▼

An iontophoretic transdermal drug delivery device adapted to releasably attach to a person\s body so that a skin-contacting surface of said device is adjacent to a portion of the person\s skin, said device having electrical connection means thereon adapted to electrically connect said device to a mu

An iontophoretic transdermal drug delivery device adapted to releasably attach to a person\s body so that a skin-contacting surface of said device is adjacent to a portion of the person\s skin, said device having electrical connection means thereon adapted to electrically connect said device to a multiplicity of current sources, said device being operable for iontophoretically driving a medicament across said skin-contacting surface of said device into said portion of the person\s skin, said device further comprising, in combination: (a) a medicament carrying layer in fluid communication with said skin-contacting surface of said device comprising a porous sheet impregnated with a medicament containing fluid; (b) an iontophoresis electrode in electrical communication with said medicament carrying layer providing means for iontophoretically driving said medicament into the person\s skin, said iontophoresis electrode further comprising a plurality of electrode channels, each electrode channel of said plurality of electrode channels being electrically isolated from other electrode channels comprising said plurality electrode channels, said plurality of electrode channels having electrical connection means connected thereto adapted for simultaneous electrical connection of selected electrode channels to the same or different current sources, said each electrode channel being in electrical communication with said medicament carrying layer; and (c) a plurality of piezoelectric elements affixed to a flexible plastic sheet affixed to and overlying said iontophoresis electrode.