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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0444300 (1995-05-18) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 1035 인용 특허 : 0 |
A glucose monitoring system continuously measures the glucose concentration in a patient\s blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visua
A glucose monitoring system continuously measures the glucose concentration in a patient\s blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The glucose monitoring system includes a glucose sensor adapted to be inserted into the venous system of the patient, where it responds to blood glucose and produces sensor signals related to the glucose concentration. The sensor signals are delivered through a suitable interconnect cable to a glucose monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the glucose sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The glucose monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the blood glucose value. The blood glucose value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.
A sensor assembly adapted for insertion into the venous system of a patient to measure the concentration of one or more substances in the patient\s blood, said sensor assembly comprising: a substrate; first and second working electrodes bonded to said substrate; a reference electrode bonded to said
A sensor assembly adapted for insertion into the venous system of a patient to measure the concentration of one or more substances in the patient\s blood, said sensor assembly comprising: a substrate; first and second working electrodes bonded to said substrate; a reference electrode bonded to said substrate; a collector electrode bonded to said substrate; means for making electrical contact with said first and second working electrodes, reference electrode, and collector electrode; a layer of insulation deposited on said substrate and means for making electrical contact so as to be interspersed between the electrodes bonded to said substrate, a prescribed surface area of each of said electrodes being exposed through said layer of insulation, whereby said first and second working electrodes, reference electrode and collector electrode are all electrically isolated from each other on said substrate; first membrane means covering said substrate and electrodes; a saline solution held within said first membrane, said saline solution being in contact with said electrodes bonded to said substrate; second membrane means covering said first membrane means, said second membrane means having a window pocket therein above the exposed surface area of said first working electrode; a prescribed enzyme placed within said window pocket; means for applying a prescribed reference voltage between said collector electrode and said reference electrode, and between said first and second working electrodes and said reference electrode, and for measuring the electrical current that flows from said first and second working electrodes; whereby when said sensor assembly is inserted in the patient\s venous system, oxygen and other substances in the blood of the patient may penetrate said first and second membrane means and electrochemically react in the presence of the prescribed enzyme held in said window pocket with the current flowing through said first working electrode, and electrochemically react in the absence of said enzyme with the current flowing through said second working electrode; said currents flowing through said first and second working electrodes thereby providing a measure of oxygen and other substances in the blood of the patient as a function of the electrochemical reactions that occur at said first and second working electrodes.
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