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Method of discovering chemicals capable of functioning as gene expression modulators

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12N-015/85
  • C12P-021/02
출원번호 US-0267834 (1994-06-28)
발명자 / 주소
  • Foulkes J. Gordon (Huntington Station NY) Leichtfried Franz (Bellerose NY) Pieler Christian (Westbury NY) Stephenson John R. (Rockville Centre NY) Franco Robert (Spencerport NY)
출원인 / 주소
  • Oncogene Science, Inc. (Uniondale NY 02)
인용정보 피인용 횟수 : 54  인용 특허 : 0

초록

The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect

대표청구항

A method of determining whether a chemical not previously known to be a modulator of protein biosynthesis specifically transcriptionally modulates the expression of a gene-of-interest which comprises: (a) contacting a sample which contains a predefined number of identical eucaryotic cells with a pre

이 특허를 인용한 특허 (54)

  1. Cook, Phillip Dan; Sanghvi, Yogesh Shantilal; Vasseur, Jean Jacques; Debart, Francoise, Backbone modified oligonucleotide analogues.
  2. Lesley Anne Glover GB; Roger Paul Hollis GB; Kenneth Stuart Killham GB, Biosensor.
  3. Shan, Bei; Learned, R. Marc; Amaral, M. Catherine; McKnight, Steven L.; de la Brousse, Fabienne Charles; Chen, Jin-Long, Cell-based drug screens for regulators of gene expression.
  4. Shan,Bei; Learned,R. Marc; Amaral,M. Catherine; McKnight,Steven L.; de la Brousse,Fabienne C.; Chen,Jin Long, Cell-based drug screens for regulators of gene expression.
  5. Housey, Gerard M., Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators.
  6. Housey, Gerard M.; Balash, Monica E., Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators.
  7. Housey, Gerard M.; Balash, Monica E., Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators.
  8. Naicker, Selvaraj A.; Yatscoff, Randall W; Foster, Robert T, Cyclosporine analogue mixtures and their use as immunomodulating agents.
  9. Naicker,Selvaraj; Yatscoff,Randall W.; Foster,Robert T., Cyclosporine analogue mixtures and their use as immunomodulating agents.
  10. Naicker,Selvaraj; Yatscoff,Randall W.; Foster,Robert T., Deuterated cyclosporin analogs and their use as immunomodulating agents.
  11. Naicker, Selvaraj; Yatscoff, Randall W.; Foster, Robert T., Deuterated cyclosporine analogs and methods of making the same.
  12. King Klim ; Dohlman Henrik G. ; Caron Marc G. ; Lefkowitz Robert J., Expression of G protein coupled receptors in yeast.
  13. King, Klim; Dohlman, Henrik G.; Caron, Marc G.; Lefkowitz, Robert J., Expression of G protein coupled receptors in yeast.
  14. King,Klim; Dohlman,Henrick G.; Caron,Marc G.; Lefkowitz,Robert J., Expression of G protein coupled receptors in yeast.
  15. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., High throughput chemical handling system.
  16. Owens, Gary K.; Madsen, Cort, Identification of a smooth muscle cell (SMC) specific smooth muscle heavy chain (SM-MHC) promoter/enhancer.
  17. Springer Caroline Joy,GBX ; Marais Richard,GBX, Intracellular expression of carboxypeptidase G2 in a nitrogen mustard prodrug system.
  18. Gerald M. Rubin ; Duojia Pan ; Jenny Rooke ; Reza Yavari ; Tian Xu, KUZ, a novel family of metalloproteases.
  19. Christopher Bentley Shumate ; Peter J. Coassin, Liquid chemical distribution method and apparatus.
  20. Shumate,Christopher Bentley; Coassin,Peter J., Liquid chemical distribution method and apparatus.
  21. Timothy D. Harris ; Richard L. Hansen ; William Karsh ; Neal A. Nicklaus ; Jay K. Trautman, Method and apparatus for screening chemical compounds.
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  23. Kauvar,Lawrence M., Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins.
  24. Harada Shun-ichi ; Rodan Gideon A. ; Sampath Kuber T., Methods and compositions for identifying morphogen analogs.
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  26. Sampath,Kuber T.; Harada,Shun ichi; Rodan,Gideon A., Methods and compositions for identifying morphogen analogs.
  27. Conkling,Mark A.; Song,Wen; Mendu,Nandini, Methods and compositions for protein production in tobacco plants with reduced nicotine.
  28. Whitney Michael A., Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary scr.
  29. Farr Spencer B. ; Todd Marque D., Methods and kits for eukaryotic gene profiling.
  30. Busby, Robert; Cali, Brian; Hecht, Peter; Holtzman, Doug; Madden, Kevin; Maxon, Mary; Milne, Todd; Norman, Thea; Royer, John; Salama, Sofie; Sherman, Amir; Silva, Jeff; Summers, Eric, Methods for improving secondary metabolite production in fungi.
  31. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Methods for rapidly identifying useful chemicals in liquid sample.
  32. Naicker, Selvaraj; Yatscoff, Randall W.; Foster, Robert T., Methods of making deuterated cyclosporin analogs.
  33. Lynda F Bonewald ; Yoichi Kato JP, Osteocyte cell lines.
  34. Conkling,Mark A.; Li,Yan, Plant promoter sequence.
  35. Negulescu Paul ; Offermanns Stefan,DEX ; Simon Melvin ; Zuker Charles, Promiscuous G-protein compositions and their use.
  36. Conkling, Mark A.; Li, Yan, Promoter fragment that is recognized by the product of the tobacco Nic gene.
  37. Kalin, Ned H.; Roseboom, Patrick H.; Landry, Charles F.; Nanda, Steven A., Promoter sequences for corticotropin releasing-factor receptor CRF2α and method of identifying agents that alter the activity of the promoter sequences.
  38. Kalin,Ned H.; Roseboom,Patrick H.; Landry,Charles F.; Nanda,Steven A., Promoter sequences for corticotropin releasing-factor receptor CRFand method of identifying agents that alter the activity of the promoter sequences.
  39. Conkling,Mark; Li,Yan, Putrescine-n-methyltransferase promoter.
  40. Oscar L. Acevedo ; Martin G. Dunkel DE; Phillip Dan Cook, Pyrimidine nucleosides.
  41. Rupp Steffen,DEX ; Robertson Laura ; Summers Eric F. ; Hecht Peter ; Roberts Radclyffe ; Madhani Hiten ; Styles Cora Ann ; Lo Hsiu-Jung,CNX ; Sherman Amir ; Cali Brian ; Fink Gerald L., Regulation of fungal gene expression.
  42. Rupp, Steffen; Robertson, Laura; Summers, Eric F.; Hecht, Peter; Roberts, Radclyffe; Madhani, Hiten; Styles, Cora Ann; Lo, Hsiu-Jung; Sherman, Amir; Cali, Brian; Fink, Gerald R., Regulation of fungal gene expression.
  43. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Regulation of quinolate phosphoribosyl transferase expression.
  44. Conkling,Mark A.; Song,Wen; Mendu,Nandini, Regulation of quinolate phosphoribosyl transferase expression.
  45. Conkling,Mark A.; Song,Wen; Mendu,Nandini, Regulation of quinolate phosphoribosyl transferase expression.
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  47. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
  48. Stylli Chari ; Beckey Samuel S. ; Shumate Christopher Bentley ; Coassin Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
  49. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
  50. Housey, Gerard M., Therameutin modulators.
  51. Housey, Gerard M., Theramutein modulators.
  52. Housey, Gerard M., Theramutein modulators.
  53. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Tobacco products with increased nicotine.
  54. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Tobacco products with reduced nicotine.
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