초록 ▼

A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically active solute (e.g. drug) with: (i) a gel network; (ii) a loading polymer that is somewhat immiscible with t

A method of loading a drug into a crosslinked polymer network and protecting the drug from the effects of inactivation is described. The method includes the steps of contacting a biologically active solute (e.g. drug) with: (i) a gel network; (ii) a loading polymer that is somewhat immiscible with the gel; and (iii) a salt, under conditions sufficient for the biologically active solute to selectively partition into the gel and the salt and the loading polymer to be entrained in the gel. A drug delivery system including a polymer gel network and the drug to be delivered is also described. The system also includes a salt and/or a loading polymer. The system protects the drug from loss of activity. In one embodiment, the polymer gel network is capable of expanding or collapsing in response to a change in an environmental condition to which the gel is exposed, the expanding or collapsing sufficient to release the drug into an environment of use.

대표청구항 ▼

A delivery system, comprising: a polymer gel network including: (i) a pharmaceutically effective amount of a biologically active solute to be delivered; (ii) a salt; and (iii) a loading polymer, wherein the salt, the loading polymer, or the salt and the loading polymer reduce loss of activity of the

A delivery system, comprising: a polymer gel network including: (i) a pharmaceutically effective amount of a biologically active solute to be delivered; (ii) a salt; and (iii) a loading polymer, wherein the salt, the loading polymer, or the salt and the loading polymer reduce loss of activity of the biologically active solute while the biologically active solute is within the gel network.