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Oligo-2′-fluoronucleotide N3′->P5′phosphoramidates 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/00
  • C07H-021/02
  • C07H-021/04
출원번호 US-0603566 (1996-02-21)
발명자 / 주소
  • Gryaznov Sergei (San Mateo CA) Schultz Ronald G. (Fremont CA)
출원인 / 주소
  • Lynx Therapeutics, Inc. (Hayward CA 02)
인용정보 피인용 횟수 : 55  인용 특허 : 1

초록 ▼

A new class of oligonucleotide N3′→P5′phosphoramidates having 2′fluoro substituents are provided that have superior acid stability. The invention includes oligo-2′-fluoronucleotide N3′→P5′phosphoramidates, methods of synthesis, and duplexes and triplexes formed with DNA and RNA. Compounds of the inv

대표청구항

A polynucleotide comprising an oligo-2′-fluoronucleoside N3′→P5′phosphoramidate segment defined by the formula: [Figure] wherein B is a purine or pyrimidine, n is an integer greater than 1, and R4 is hydrogen or a phosphate protecting group.

이 특허에 인용된 특허 (1)

  1. Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
    상세보기

이 특허를 인용한 특허 (55)

  1. Gryaznov,Sergei; Schultz,Ronald G., 2'-arabino-fluorooligonucleotide N3'→P5' phosphoramidates: their synthesis and use.
    상세보기
  2. Prakash, Thazha P.; Baker, Brenda F.; Eldrup, Anne B.; Manoharan, Muthiah; Bhat, Balkrishen; Griffey, Richard; Swayze, Eric E.; Crooke, Stanley T., 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations.
    상세보기
  3. Gryaznov, Sergei; Schultz, Ronald G., 2′-arabino-fluorooligonucleotide N3′-P5′ phosphoramidates: their synthesis and use.
    상세보기
  4. Gryaznov, Sergei M.; Schultz, Ronald G., 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use.
    상세보기
  5. Gryaznov, Sergei M.; Schultz, Ronald G., 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use.
    상세보기
  6. Gryaznov, Sergei; Schultz, Ronald G., 2′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use.
    상세보기
  7. Schinazi, Raymond F.; Liotta, Dennis C.; Chu, Chung K.; McAtee, J. Jeffrey; Shi, Junxing; Choi, Yongseok; Lee, Kyeong; Hong, Joon H., 2′-fluoronucleosides.
    상세보기
  8. Roderic M. K. Dale, Arrays with modified oligonucleotide and polynucleotide compositions.
    상세보기
  9. Imanishi, Takeshi; Obika, Satoshi, Bicyclonucleoside analogues.
    상세보기
  10. Gryaznov, Sergei M.; Zielinska, Daria; Pruzan, Ronald A.; Lindquist, Jeffrey N., C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders.
    상세보기
  11. Gryaznov, Sergei M.; Zielinska, Daria; Pruzan, Ronald A.; Lindquist, Jeffrey N., C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders.
    상세보기
  12. Crooke, Stanley T., Chimeric oligomeric compounds and their use in gene modulation.
    상세보기
  13. Allerson, Charles; Bhat, Balkrishen; Eldrup, Anne B.; Manoharan, Muthiah; Griffey, Richard H.; Baker, Brenda F.; Swayze, Eric E., Compositions comprising alternating 2′-modified nucleosides for use in gene modulation.
    상세보기
  14. Bennett, C. Frank; McKay, Robert; Monia, Brett P.; Baker, Brenda F.; Sioufi, Namir, Conjugates for use in hepatocyte free uptake assays.
    상세보기
  15. Baker, Brenda F.; Kraynack, Bryan A., Double stranded constructs comprising one or more short strands hybridized to a longer strand.
    상세보기
  16. Woolf, Tod M.; Kamens, Joanne; Khvorova, Anastasia; Salomon, William, Inhibition of MAP4K4 through RNAI.
    상세보기
  17. Kamens, Joanne; Khvorova, Anastasia, Inhibition of PCSK9 through RNAI.
    상세보기
  18. Kamens, Joanne; Khvorova, Anastasia, Inhibition of PCSK9 through RNAi.
    상세보기
  19. Karl Tryggvason SE; Olavi Lukkarinen FI; Pirkko Heikkila SE; Teija Parpala FI, Method for viral vector delivery.
    상세보기
  20. Peters, Marco; Scott, Roderick Euan Milne; Tully, Timothy P., Methods of enhancing long term memory formation by inhibition of Gpr12.
    상세보기
  21. Pavco, Pamela A.; Kamens, Joanne; Woolf, Tod M.; Salomon, William; Khvorova, Anastasia, Modified RNAi polynucleotides and uses thereof.
    상세보기
  22. Gryaznov, Sergei; Pongracz, Krisztina, Modified oligonucleotides for telomerase inhibition.
    상세보기
  23. Gryaznov, Sergei; Pongracz, Krisztina, Modified oligonucleotides for telomerase inhibition.
    상세보기
  24. Gryaznov, Sergei; Pongracz, Krisztina, Modified oligonucleotides for telomerase inhibition.
    상세보기
  25. Gryaznov, Sergei; Pongracz, Krisztina, Modified oligonucleotides for telomerase inhibition.
    상세보기
  26. Gryaznov, Sergei; Pongracz, Krisztina, Modified oligonucleotides for telomerase inhibition.
    상세보기
  27. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Miller, Michelle; Bulock, Karen G., Neutral nanotransporters.
    상세보기
  28. Krull, Ulrich J.; Piunno, Paul A.; Hudson, Robert H. E.; Damha, Masad; Uddin, Andre H., Nucleic acid biosensor diagnostics.
    상세보기
  29. Gryaznov, Sergei; Pongracz, Krisztina; Matray, Tracy, Oligonucleotide N3′→P5′ Thiophosphoramidates: their synthesis and use.
    상세보기
  30. Gryaznov, Sergei; Pongracz, Krisztina; Matray, Tracy, Oligonucleotide N3'→P5' thiophosphoramidates: their synthesis and administration to treat neoplasms.
    상세보기
  31. Ramiya, Premchandran H., Oligonucleotide compositions and methods of making the same.
    상세보기
  32. Khvorova, Anastasia; Aronin, Neil; Alterman, Julia, Oligonucleotide compounds for targeting huntingtin mRNA.
    상세보기
  33. Khvorova, Anastasia; Moore, Melissa; Turanov, Anton A.; Karumanchi, Ananth, Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders.
    상세보기
  34. Crooke, Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.
    상세보기
  35. Tryggvason, Karl; Lukkarinen, Olavi; Heikkila , Pirkko; Parpala, Teija, Perfusion apparatus and methods for pharmaceutical delivery.
    상세보기
  36. Samarsky, Dmitry; Woolf, Tod M., Phagocytic cell delivery of RNAI.
    상세보기
  37. Bhat, Balkrishen; Swayze, Eric E.; Prakash, Thazha P.; Allerson, Charles; Dande, Prasad; Griffey, Richard H., Positionally modified siRNA constructs.
    상세보기
  38. Gryaznov, Sergei; Pongracz, Krisztina, RNA amidates and thioamidates for RNAi.
    상세보기
  39. Gryaznov, Sergei; Pongracz, Krisztina, RNA amidates and thioamidates for RNAi.
    상세보기
  40. Woolf, Tod M.; Kamens, Joanne; Salomon, William; Khvorova, Anastasia, RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality.
    상세보기
  41. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Pavco, Pamela A.; Libertine, Lyn; Cardia, James; Bulock, Karen G., RNA interference in dermal and fibrotic indications.
    상세보기
  42. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Pavco, Pamela A.; Libertine, Lyn; Cardia, James; Bulock, Karen G., RNA interference in dermal and fibrotic indications.
    상세보기
  43. Libertine, Lyn; Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Cardia, James; Pavco, Pamela A., RNA interference in ocular indications.
    상세보기
  44. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Pavco, Pamela A.; Cardia, James, RNA interference in skin indications.
    상세보기
  45. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Pavco, Pamela A.; Cardia, James, RNA interference in skin indications.
    상세보기
  46. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Pavco, Pamela A.; Cardia, James, RNA interference in skin indications.
    상세보기
  47. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Cardia, James, Reduced size self-delivering RNAi compounds.
    상세보기
  48. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Cardia, James, Reduced size self-delivering RNAi compounds.
    상세보기
  49. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Cardia, James, Reduced size self-delivering RNAi compounds.
    상세보기
  50. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Cardia, James, Reduced size self-delivering RNAi compounds.
    상세보기
  51. Khvorova, Anastasia; Salomon, William; Kamens, Joanne; Samarsky, Dmitry; Woolf, Tod M.; Cardia, James, Reduced size self-delivering RNAi compounds.
    상세보기
  52. Gryaznov, Sergei M.; Pongracz, Krisztina; Zielinska, Daria, Synthesis of protected 3′-amino nucleoside monomers.
    상세보기
  53. Gryaznov, Sergei M.; Pongracz, Krisztina; Zielinska, Daria, Synthesis of protected 3′-amino nucleoside monomers.
    상세보기
  54. Gryaznov, Sergei M.; Pongracz, Krisztina; Zielinska, Daria, Synthesis of protected 3′-amino nucleoside monomers.
    상세보기
  55. Gryaznov,Sergei; Pongracz,Krisztina; Matray,Tracy, Treating cancer using an oligonucleotide N3'->N5' thiophosphoramidate.
    상세보기

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