초록

An electrotransport drug delivery device which delivers an anti-inflammatory agent in order to reduce skin irritation associated with electrotransport delivery of the drug is provided. The anti-inflammatory agent is selected from hydrocortisone, esters of hydrocortisone and salts thereof.

대표청구항 ▼

An electrotransport device for delivering an ionized drug through a body surface into the systemic circulation and an uncharged anti-inflammatory agent, wherein the drug and agent are different, to the body surface exposed to the device, the device comprising: a) an anodidcathodic pair of reservoirs

An electrotransport device for delivering an ionized drug through a body surface into the systemic circulation and an uncharged anti-inflammatory agent, wherein the drug and agent are different, to the body surface exposed to the device, the device comprising: a) an anodidcathodic pair of reservoirs adapted to be placed in ion-transmitting relation with sites on a body surface, at least one of said reservoirs being a donor reservoir containing: (i) said ionized drug; and (ii) a solution of said uncharged anti-inflammatory agent dissolved in an aqueous solution of a material selected from the group consisting of alcohols, glycols, glycerols, cyclodextrins and non-ionic surfactants; and b) a source of electrical power electrically connected to the reservoirs when the reservoirs are in ion-transmitting relation with said body surface and providing an electrotransport current through the reservoirs and the body surface at a level sufficient to deliver the uncharged anti-inflammatory agent at a rate sufficient to reduce irritation at the site of administration.