초록 ▼

There is provided an apparatus for gene therapy to transfer or introduce, in vivo, a gene for treatment into a cell located at a target portion of a patient, so that the gene can be transferred with a high probability within a short period of time. The apparatus is applicable to all cell species. In

There is provided an apparatus for gene therapy to transfer or introduce, in vivo, a gene for treatment into a cell located at a target portion of a patient, so that the gene can be transferred with a high probability within a short period of time. The apparatus is applicable to all cell species. In addition to simple supply of a gene to the cell of the patient, the gene is forcibly transferred to the cell without depending on natural cellular physiology. For example, catheters are mounted on a probe inserted into a body cavity, and the gene is supplied from a reservoir which stores the gene to the surface of a human living cell of the target portion in the body cavity through needle cannulas attached to the distal ends of the catheters. A pulse voltage is applied to the needle cannulas to form a pore in the surface of the human living cell upon application of the pulse voltage. The gene is transferred into the human living cell through the pore.

대표청구항 ▼

An apparatus for gene therapy, comprising: a probe which is insertable into a body cavity; supply means provided in said probe for supplying a gene or a gene-packaging particle onto a surface of a human living cell located at a target portion in the body cavity; and a plurality of small needles in s

An apparatus for gene therapy, comprising: a probe which is insertable into a body cavity; supply means provided in said probe for supplying a gene or a gene-packaging particle onto a surface of a human living cell located at a target portion in the body cavity; and a plurality of small needles in said probe and capable of protruding from a distal end of said probe for mechanically forming a plurality of pores in a cell membrane of the human living cell in order to transfer the gene or gene-packaging particle into the cell through the plurality of pores.