초록 ▼

A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as a liquid with the resultant formation of a gel depot for the controlled release of the drug. The system comprises an injectable biodegradable block copolymeric drug delivery liqu

A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as a liquid with the resultant formation of a gel depot for the controlled release of the drug. The system comprises an injectable biodegradable block copolymeric drug delivery liquid having reverse thermal gelation properties. The delivery liquid is an aqueous solution having dissolved or dispersed therein an effective amount of a drug intimately contained in a biodegradable block copolymer matrix. The copolymer has a reverse gelation temperature below the body temperature of the animal to which it is administered and is made up of (i) a hydrophobic A polymer block comprising a member selected from the group consisting of poly(aa

대표청구항 ▼

An injectable biodegadable block copolymeric drug delivery liquid having reverse thermal gelation properties comprising an aqueous solution having uniformly contained therein between about 3 and 40% by weight of (a) an effective amount of a drug intimately contained in (b) a biodegradable block copo

An injectable biodegadable block copolymeric drug delivery liquid having reverse thermal gelation properties comprising an aqueous solution having uniformly contained therein between about 3 and 40% by weight of (a) an effective amount of a drug intimately contained in (b) a biodegradable block copolymer comprising (I) less than 50% by weight of a hydrophobic A polymer block comprising a member selected from the group consisting of poly(a50% by weight of a hydrophilic B polymer block comprising a polyethylene glycol; and wherein said liquid is maintained at a temperature below the lower critical solution temperature of said block copolymer.