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A substrate such as a catheter or a guide wire is provided with a lubricous, hydrophilic abrasion-resistant coating by: a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a polymer having organic acid functional groups and a polyfunctio

A substrate such as a catheter or a guide wire is provided with a lubricous, hydrophilic abrasion-resistant coating by: a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a polymer having organic acid functional groups and a polyfunctional crosslinking agent having functional groups capable of reacting with organic acid groups, and drying the coating to obtain a substantially water-insoluble coating layer having excess polyfunctional including functional groups being reactive with organic acid groups remaining, and b) contacting the dried coating layer obtained in a) with a second aqueous coating composition comprising an aqueous solution or dispersion of a hydrophilic polymer having organic acid functional groups, and drying the combined coating, the hydrophilic polymer thereby becoming bonded to the polymer of the first coating composition through the excess crosslinking agent. The drying can be carried out at ambient (room) temperature.

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A method of providing a substrate, with a hydrophilic coating which becomes lubricous when contacted with an aqueous fluid, said method comprising: a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a polymer having organic acid functio

A method of providing a substrate, with a hydrophilic coating which becomes lubricous when contacted with an aqueous fluid, said method comprising: a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a polymer having organic acid functional groups and an excess of a polyfunctional cross-linking agent having functional groups being capable of reacting with organic acid groups, and drying said first coating composition to obtain a substantially water-insoluble coating layer still including functional groups being reactive with organic acid groups, and b) forming a continuous lubricious surface over said first coating composition by contacting said dried first coating composition with a second aqueous coating composition comprising an aqueous solution or dispersion of a hydrophilic polymer having organic acid functional groups, and drying the combined coatings, to bond the hydrophilic polymer to the polymer of the first coating composition through said excess cross-linking agent.